Abstract: A chemo-thermo applicator insertable into a tubular membrane in the body of an individual to occupy a site therein in which the surface of the membrane is disrupted by cancerous lesions. The applicator includes concentric inner and outer tubular balloons in which the annular space therebetween is filled with a chemotherapy supply the outer balloon being perforated. In operation, a stream of heated air is fed into the inner balloon which acts to inflate this balloon and to heat the supply to cause it to melt and form a cream. Inflation of the inner balloon acts to expand the outer balloon causing it to conform to the surface of the membrane. The pressure imposed on the supply as the inner balloon expands, forces the heated cream to extrude through the outer balloon perforations to coat the surface of the membrane with the heated cream which then functions as a chemo-thermo agent to destroy the cancerous lesions.