Abstract: Container lid with a cooling reservoir for releasably covering a disposable cup containing a hot beverage. The cooling reservoir includes a side wall with a small opening to allow a small volume of the hot beverage to pass into the cooling reservoir in which the beverage sufficiently cools down to enable the consumer to sip the beverage.

Abstract: Device for protecting large wounds, such as surgical incisions, from the environment. The device contains a semi-rigid, flexible plate with attaching means which direct environmental pressures away from the wound.

Abstract: A twist valve for use in a fluid delivery system is provided for selectively allowing fluid flow and blocking fluid flow therethrough. The twist valve is in communication with a pre-filled flexible container and includes a proximal part and a distal part each having a fluid inlet and a fluid outlet. The proximal and distal parts are equipped with cylindrical helical surfaces which allow them to move toward or away from each other when a twisting force is applied to them. The fluid outlet of the proximal part is blocked with a stopper in the distal part when the twist valve is in the closed position, and is unblocked by the stopper when the twist valve is in the open position.

Abstract: Soffit ventilation system in a building having a horizontal soffit with a plurality of vents and a strip of mat of randomly oriented synthetic fibers covering the attic-facing side of the soffit. An alternative embodiment has a panel of air-impermeable material having upper and lower sections. The strip of mat of randomly oriented synthetic fibers is sandwiched between the lower section and the vertical side of the walls allowing the passage of air into the attic through an opening between the lower section and the upper section of the air-impermeable panel.

Abstract: A self-aligning reinforced plunger rod and a non-elastomeric plastic plunger insert assembly for use with an elastomeric plunger in a cartridge or syringe barrel, the plunger rod having a first, second, third and fourth sides, a distal end with an end disc, a proximal end with a thumb rest, and a plunger rod tip integral with the end disc and having a neck portion and a ball portion for engagement with a cavity in the non-elastomeric plastic plunger insert. Connecting the end disc and thumb rest there are: four longitudinal radially extending rectangular vanes spaced about 90.degree.

Abstract: A vial access adapter for withdrawal of a medical fluid contained in a vial which includes a vial access adapter body having a circular top wall with a plurality of vent holes, a circular second wall spaced from the top wall, and a cylindrical side wall which walls define a chamber for holding an anti-bacterial filter. A first spike centrally located in the vial access adapter body extends through the top wall, chamber, and bottom wall, with one end extending above the top wall terminating in a threaded luer connector, while the other end terminates in a sharp point. A flow channel extends through the first spike designed for withdrawal of the medical fluid from the vial. A second spike positioned parallel to the first spike extends from the second wall, one end of which extends into the chamber, and the other end terminates in a sharp point. A flow channel extends through the second spike designed for air flow from the chamber into the vial.

Abstract: Method and apparatus for removing an elastomeric closure from the tapered tip of a pre-filled syringe or cartridge barrel stoppered at its open end by a slidable plunger; measuring the removal force required to remove the elastomeric closure from the tapered tip of the barrel; and subsequently measuring the breakaway and running forces required to move the plunger from its initial position toward the distal end of the syringe or cartridge barrel.

Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.

Abstract: Metal complexes of new ligands of the formula ##STR1## are useful as agents for medical imaging, particularly MRI, for in vitro or in vivo diagnostic or as radiopharmaceuticals. In these compounds, X--R.sup.1 --Y is a coordinating group able to form a highly stable complex with metal ions. Suitable units are for example derivatives of ortho-phenanthroline or of an hydroxamic acid. R.sup.2 and R.sup.3 are reactive functions such as amines or carboxylic groups. R.sup.4 and R.sup.5 are ligands, for instance diethylenetriaminepentaacetic acid 1,4,7,10-tetraacetic acid (DTPA), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) or 1,4,8,11-tetraazacyclotetradecane-N, N', N", N'"-tetraacetic acid (TETA), of a different type than the X--R.sup.1 --Y units and able to strongly encapsulate metal ions with which the X--R.sup.1 --Y moieties form less stable chelates.

Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided.The compound of formula I, having the structure: ##STR1## wherein R.sub.1, R.sub.2 ;X; and ArY, Z and n are as described in the specification.

Abstract: A kit containing a solution of boronic acid adducts of technetium-99 m dioxime complexes; and hydroxypropyl gamma cyclodextrin to maintain the solution free of particulate matter originating from the formulation.

Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compound of formulae IIA, having the structure: ##STR1## wherein R.sub.1, R.sub.2 ;X.sub.4, X.sub.5 ; andAr and n are as described in the specification.

Abstract: Compounds having formulae I, II or III, or pharmaceutically acceptable salts thereof, ##STR1## wherein ##STR2## R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are the same or different and are hydrogen, alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, haloalkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or carboxamido alkyl with the proviso that in formula I R.sub.2 and R.sub.3 cannot be methyl; andm, n and p are the same or different and are 0-24 with the proviso that m+n.ltoreq.24, are useful as contrast agents in x-ray imaging compositions and methods.

Abstract: Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.

Abstract: Multiple use universal connector designed for use in various containers having a fluid port for accessing to the content of the container or for transferring fluid into the container. The multiple use universal connector incorporates a diaphragm capable of being penetrated repeatedly by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means. The multiple use universal connector re-seals itself after being penetrated and the access means removed therefrom.