Patents Represented by Attorney Isis Patent Department

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  • Preparation of phosphorothioate oligomers
    Patent number: 6861518
    Abstract: Methods and Intermediates for the Preparation of Oligomers Containing Diastereomerically Enriched Phosphorothioate Linkages are Disclosed.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: March 1, 2005
    Assignee: McGill University
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin, Jianchao Wang
  • Oligomer phosphoramidite compositions and processes for synthesizing the same
    Patent number: 6858722
    Abstract: Synthetic processes are provided wherein oligomers are prepared using phosphoramidite compositions. Oligomers having phosphodiester, phosphorothioate, phosphorodithioate covalent linkages are prepared that can include other covalent linkages. Also provided are compositions useful in such processes.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: February 22, 2005
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Daniel C. Capaldi, Douglas L. Cole
  • Process for the synthesis of oligomeric compounds
    Patent number: 6858715
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: February 22, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Oligonucleotide analogs having modified dimers
    Patent number: 6849723
    Abstract: Modified dimers having a ribose sugar moiety in the 5? nucleoside and a 2? modified sugar in the 3? nucleoside are provided. The modified dimers are useful in the preparation of oligonucleotide analogs having enhanced properties compared to native oligonucleotides, including increased nuclease resistance, enhanced binding affinity and improved protein binding.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: February 1, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Muthiah Manoharan, Balkrishen Bhat
  • Oligonucleotide and nucleotide amine analogs, methods of synthesis and use
    Patent number: 6828434
    Abstract: Novel amine compounds are provided by the present invention. Methods of preparing and using said novel amine compounds are also provided.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: December 7, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Muthiah Manoharan, P. Dan Cook
  • Labeled oligonucleotides, methods for making same, and compounds useful therefor
    Patent number: 6825338
    Abstract: Selectively functionalized oligonucleotides, methods for making same, and compounds useful therefor are disclosed. The oligonucleotides can be selectively functionalized with a first conjugate group at the 3′-terminial position and optionally functionalized with a second conjugate group at the 5′-terminal position and/or one or more internucleotides. Alternatively, the oligonucleotides can be selectively functionalized with a first conjugate group at the 5′-terminal position and optionally functionalized with a second conjugate group at one or more internucleotides. In yet another embodiment, the oligonucleotides can be functionalized with a first conjugate group at one or more internucleotides and with a second conjugate group at one or more different internucleotides.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: November 30, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Muthiah Manoharan, Andrei P. Guzaev
  • Phosphorothioate oligonucleotides having modified internucleoside linkages
    Patent number: 6811975
    Abstract: Novel compounds that mimic and/or modulate the activity of wild-type nucleic acids. In general, the compounds are phosphorothioate oligonucleotides wherein the 5′-terminal internucleoside linkage or the 5′- and 3′-terminal linkages are modified.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: November 2, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Muthiah Manoharan