Abstract: A colored institutional towel comprising ground warp, fill, and pile warped yarns, all of said yarns being colored by intimately draw blending a predetermined amount of pre-dyed polyester fiber with cotton fiber when the yarn is spun and twisted to thereby form a predetermined color for the institutional towel.
Type:
Grant
Filed:
December 20, 2002
Date of Patent:
December 23, 2003
Assignee:
Blair Mills L.P.
Inventors:
David Eugene Hamby, Wilbur Mattison Rice
Abstract: A pharmaceutical tablet comprising a core and a film coating wherein the core comprises an NSAID and the film coating comprises a polymer and misoprostol.
Abstract: A method of advertising in a shower for the hospitality industry including providing replaceable advertisements on a shower closure, for example a door, curtain or the like.
Abstract: The present invention relates to a process for the production of (S)-1,2,3,4-tetrahydro-6,7-dialkoxy-3-isoquinolinecarboxylic acid compounds (1) and their derivatives from Levodopa (L-Dopa). The ultimately prepared compounds are used as intermediates for, but not limited to, the preparation of substituted derivatives of 1,2,3,4-tetrahydro-6,7-dialkoxy-3-isoquinolinecarboxylic acid
wherein
R1 is hydrogen, lower alkyl, C2-C12 acyl, or R1O together are methylenedioxy;
R2 is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, substituted aryl, aralkyl or substituted aralkyl group; and
R3 is hydrogen, C2-C12 acyl group, benzyl, alkoxylcarbonyl group, or aralkoxyl carbonyl group.
Abstract: There are disclosed novel Stavudine solvates as follows: Stavudine NN-dimethyllacetamide solvates; Stavudine NN-dimethylacrylamide solvates and Stavudine NN-dimethylpropionamide solvates and processes for producing Stavudine NN-dimethylacetamide solvates, Stavudine NN dimethylacrylamide solvates and Stavudine NN dimethylpropionamide solvates which results in pure Stavudine.
Abstract: A process for the preparation of 1,3-oxathiolane nucleoside analogues in predominantly the cis-form, from mixture of cis-/trans-1,3-oxathiolane nucleosides or their protected derivatives thereof, comprising:
(i) treatment of the cis-/trans-1,3-oxathiolane nucleosides (or protected derivatives thereof) with a pyrimidine base (or it derivatives thereof) and an acid,
(ii) adding a suitable acid to the obtained cis-/trans-mixture of isomers,
(iii) selective crystallization of the desired cis-isomer salt from a solvent or combination of solvents, and
(iv) treatment of the predominantly cis-isomer salt with a suitable base to offer the free 1,3-oxathiolane nucleosides, and thereafter optionally repeating steps (i) to (iv) inclusive.
Type:
Grant
Filed:
June 18, 2001
Date of Patent:
July 29, 2003
Assignee:
Brantford Chemicals Inc.
Inventors:
K. S. Keshava Murthy, Gurijala V. Reddy, Zhi-xian Wang, Chandrawansha B. W. Senanayake
Abstract: A process for the preparation of Nefazodone hydrochloride comprising direct conversion of semicarbazide dihydrochloride 3 into Nefazodone hydrochloride which process involves a reaction of triethyl orthopropionate in the presence of trimethylsilylchloride and hydrochloric acid.
Type:
Grant
Filed:
September 17, 2001
Date of Patent:
July 22, 2003
Assignee:
Brantford Chemicals Inc.
Inventors:
K. S. Keshava Murthy, Bhaskar Reddy Guntoori, Daqing Che
Abstract: This invention relates to the preparation of 3-sulfonamido-4-arylaminopyridines by heating a 3-sulfonamido-4-aminopyridine with an aryl halide in the presence of an alkaline compound, a copper-containing agent and in the presence of a polar protic solvent.
Type:
Grant
Filed:
November 14, 2002
Date of Patent:
July 15, 2003
Assignee:
Brantford Chemicals Inc.
Inventors:
Carlos B. Zetina-Rocha, Bhaskar Reddy Guntoori, Stephen E. Horne
Abstract: A process for the manufacture of 3,5-diamino-6-substituted-1,2,4-triazines is disclosed which comprises the steps of:
(a) reacting a compound of formula (II):
with aminoguanidine salts,
(b) dehydrating the compound obtained to form a compound of formula IV,
and
(c) cyclization of the compound of formula IV into a 3,5-diamino-6-substituted-1,2,4-triazine compound of formula I or into a hydrated form thereof.
Type:
Grant
Filed:
January 16, 2002
Date of Patent:
July 1, 2003
Assignee:
Brantford Chemicals Inc.
Inventors:
Bhaskar Reddy Guntoori, Daqing Che, K. S. Keshava Murthy
Abstract: A pharmaceutical composition for oral administration comprising a co-micronized mixture of fenofibrate and a solid excipient that is not a surfactant.
Abstract: The present invention describes the precise metering of soldering material realized in a preferred desktop preferably portable device designated for hand-soldering in small and medium volume operations. It combines the fully automated process of precise metering of the soldering wire for high accuracy and quality soldering with the freedom of a hand-operated soldering process.
Abstract: A coloured institutional towel comprising ground warp, fill, and pile warped yarns, all of said yarns being colored by intimately draw blending a predetermined amount of pre-dyed polyester fiber with cotton fiber when the yarn is spun and twisted to thereby form a predetermined color for the institutional towel.
Type:
Grant
Filed:
December 26, 2000
Date of Patent:
April 15, 2003
Assignee:
Blair Mills, L.P.
Inventors:
David Eugene Hamby, Wilbur Mattison Rice
Abstract: Solid pharmaceutical compositions comprising quinapril magnesium can be made by reacting a quinapril or an acid addition salt thereof with an alkaline magnesium compound in the presence of a solvent so as to convert the quinapril or quinapril acid addition salt to quinapril magnesium.
Abstract: A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2′-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure.
Type:
Grant
Filed:
April 24, 2001
Date of Patent:
January 14, 2003
Assignee:
Apotex Inc.
Inventors:
Khashayar Karimian, Tim Fat Tam, Yong Tao, Yiwei Li, Gary Doucette
Abstract: A pharmaceutical composition for controlled onset and sustained release of an active ingredient, said composition comprising:
(i) a core comprising:
(a) an active ingredient;
(b) a hydrophilic carrier;
(c) a hydrodynamic diffusion enhancer; and optionally
(d) conventional pharmaceutically acceptable excipients selected from the group consisting of binders, fillers and lubricants and combinations thereof; and
(ii) a functional coating membrane surrounding said core.
Abstract: Motorized wheels in a wheelchair or other light vehicle are each mounted on an axle for limited rotation relative to a secondary connection to the frame of the vehicle which incorporates a sensor providing feedback which controls the motor according to torque sensed through the secondary connection. The motor and associated gearing and control circuitry are housed within a wheel hub of which a drum supporting a wheel rim is supported at its inner surface on multiple bearings spaced around its periphery.
Abstract: A process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives of general formula I:
or their pharmaceutically acceptable salts, wherein the meaning of X is hydrogen, carboxyl, alkoxycarbonyl, aryloxycarbonyl, nitrile, or carbamoyl of formula
wherein R1 and R2 can be individually or simultaneously hydrogen, alkyl or part of a heterocyclic structure; Z can be hydrogen, halogen, alkyl, aryl, aryloxy or alkoxy group.
Type:
Grant
Filed:
July 11, 2001
Date of Patent:
December 17, 2002
Assignee:
Brantford Chemicals Inc.
Inventors:
Stephen E. Horne, Gamini Weeratunga, Bogdan M. Comanita, Jaipal Reddy Nagireddy, Laura Kaye McConachie