Patents Represented by Attorney, Agent or Law Firm Ivor M. Hughes
  • Patent number: 6666234
    Abstract: A colored institutional towel comprising ground warp, fill, and pile warped yarns, all of said yarns being colored by intimately draw blending a predetermined amount of pre-dyed polyester fiber with cotton fiber when the yarn is spun and twisted to thereby form a predetermined color for the institutional towel.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: December 23, 2003
    Assignee: Blair Mills L.P.
    Inventors: David Eugene Hamby, Wilbur Mattison Rice
  • Patent number: 6667054
    Abstract: Tablets for oral administration comprising metformin hydrochloride and methylcellulose.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: December 23, 2003
    Inventor: Bernard Charles Sherman
  • Patent number: 6656503
    Abstract: A pharmaceutical tablet comprising a core and a film coating wherein the core comprises an NSAID and the film coating comprises a polymer and misoprostol.
    Type: Grant
    Filed: July 11, 2000
    Date of Patent: December 2, 2003
    Inventor: Bernard Charles Sherman
  • Patent number: 6655444
    Abstract: A method of advertising in a shower for the hospitality industry including providing replaceable advertisements on a shower closure, for example a door, curtain or the like.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: December 2, 2003
    Assignee: 420820 Ontario Limited
    Inventors: Shaul Goldenberg, Sean Davies
  • Patent number: 6642384
    Abstract: The present invention relates to a process for the production of (S)-1,2,3,4-tetrahydro-6,7-dialkoxy-3-isoquinolinecarboxylic acid compounds (1) and their derivatives from Levodopa (L-Dopa). The ultimately prepared compounds are used as intermediates for, but not limited to, the preparation of substituted derivatives of 1,2,3,4-tetrahydro-6,7-dialkoxy-3-isoquinolinecarboxylic acid wherein R1 is hydrogen, lower alkyl, C2-C12 acyl, or R1O together are methylenedioxy; R2 is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, substituted aryl, aralkyl or substituted aralkyl group; and R3 is hydrogen, C2-C12 acyl group, benzyl, alkoxylcarbonyl group, or aralkoxyl carbonyl group.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: November 4, 2003
    Assignee: Brantford Chemicals Inc.
    Inventors: Zhi-Xian Wang, Stephen E. Horne
  • Patent number: 6635753
    Abstract: There are disclosed novel Stavudine solvates as follows: Stavudine NN-dimethyllacetamide solvates; Stavudine NN-dimethylacrylamide solvates and Stavudine NN-dimethylpropionamide solvates and processes for producing Stavudine NN-dimethylacetamide solvates, Stavudine NN dimethylacrylamide solvates and Stavudine NN dimethylpropionamide solvates which results in pure Stavudine.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: October 21, 2003
    Assignee: Brantford Chemicals Inc.
    Inventors: Bruno K. Radatus, K. S. Keshava Murthy
  • Patent number: 6600044
    Abstract: A process for the preparation of 1,3-oxathiolane nucleoside analogues in predominantly the cis-form, from mixture of cis-/trans-1,3-oxathiolane nucleosides or their protected derivatives thereof, comprising: (i) treatment of the cis-/trans-1,3-oxathiolane nucleosides (or protected derivatives thereof) with a pyrimidine base (or it derivatives thereof) and an acid, (ii) adding a suitable acid to the obtained cis-/trans-mixture of isomers, (iii) selective crystallization of the desired cis-isomer salt from a solvent or combination of solvents, and (iv) treatment of the predominantly cis-isomer salt with a suitable base to offer the free 1,3-oxathiolane nucleosides, and thereafter optionally repeating steps (i) to (iv) inclusive.
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: July 29, 2003
    Assignee: Brantford Chemicals Inc.
    Inventors: K. S. Keshava Murthy, Gurijala V. Reddy, Zhi-xian Wang, Chandrawansha B. W. Senanayake
  • Patent number: 6596866
    Abstract: A process for the preparation of Nefazodone hydrochloride comprising direct conversion of semicarbazide dihydrochloride 3 into Nefazodone hydrochloride which process involves a reaction of triethyl orthopropionate in the presence of trimethylsilylchloride and hydrochloric acid.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: July 22, 2003
    Assignee: Brantford Chemicals Inc.
    Inventors: K. S. Keshava Murthy, Bhaskar Reddy Guntoori, Daqing Che
  • Patent number: 6593475
    Abstract: This invention relates to the preparation of 3-sulfonamido-4-arylaminopyridines by heating a 3-sulfonamido-4-aminopyridine with an aryl halide in the presence of an alkaline compound, a copper-containing agent and in the presence of a polar protic solvent.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: July 15, 2003
    Assignee: Brantford Chemicals Inc.
    Inventors: Carlos B. Zetina-Rocha, Bhaskar Reddy Guntoori, Stephen E. Horne
  • Patent number: 6586593
    Abstract: A process for the manufacture of 3,5-diamino-6-substituted-1,2,4-triazines is disclosed which comprises the steps of: (a) reacting a compound of formula (II):  with aminoguanidine salts, (b) dehydrating the compound obtained to form a compound of formula IV,  and (c) cyclization of the compound of formula IV into a 3,5-diamino-6-substituted-1,2,4-triazine compound of formula I or into a hydrated form thereof.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: July 1, 2003
    Assignee: Brantford Chemicals Inc.
    Inventors: Bhaskar Reddy Guntoori, Daqing Che, K. S. Keshava Murthy
  • Patent number: 6555135
    Abstract: A pharmaceutical composition for oral administration comprising a co-micronized mixture of fenofibrate and a solid excipient that is not a surfactant.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: April 29, 2003
    Inventor: Bernard Charles Sherman
  • Patent number: 6550663
    Abstract: The present invention describes the precise metering of soldering material realized in a preferred desktop preferably portable device designated for hand-soldering in small and medium volume operations. It combines the fully automated process of precise metering of the soldering wire for high accuracy and quality soldering with the freedom of a hand-operated soldering process.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: April 22, 2003
    Inventor: Leonid Poletaev
  • Patent number: 6546965
    Abstract: A coloured institutional towel comprising ground warp, fill, and pile warped yarns, all of said yarns being colored by intimately draw blending a predetermined amount of pre-dyed polyester fiber with cotton fiber when the yarn is spun and twisted to thereby form a predetermined color for the institutional towel.
    Type: Grant
    Filed: December 26, 2000
    Date of Patent: April 15, 2003
    Assignee: Blair Mills, L.P.
    Inventors: David Eugene Hamby, Wilbur Mattison Rice
  • Patent number: 6531486
    Abstract: Solid pharmaceutical compositions comprising quinapril magnesium can be made by reacting a quinapril or an acid addition salt thereof with an alkaline magnesium compound in the presence of a solvent so as to convert the quinapril or quinapril acid addition salt to quinapril magnesium.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: March 11, 2003
    Assignee: Apotex Inc.
    Inventor: Bernard Charles Sherman
  • Patent number: 6506929
    Abstract: A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2′-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure.
    Type: Grant
    Filed: April 24, 2001
    Date of Patent: January 14, 2003
    Assignee: Apotex Inc.
    Inventors: Khashayar Karimian, Tim Fat Tam, Yong Tao, Yiwei Li, Gary Doucette
  • Patent number: 6500459
    Abstract: A pharmaceutical composition for controlled onset and sustained release of an active ingredient, said composition comprising: (i) a core comprising: (a) an active ingredient; (b) a hydrophilic carrier; (c) a hydrodynamic diffusion enhancer; and optionally (d) conventional pharmaceutically acceptable excipients selected from the group consisting of binders, fillers and lubricants and combinations thereof; and (ii) a functional coating membrane surrounding said core.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: December 31, 2002
    Inventors: Harinderpal Chhabra, Shyamal K. Sarkar
  • Patent number: 6494278
    Abstract: Motorized wheels in a wheelchair or other light vehicle are each mounted on an axle for limited rotation relative to a secondary connection to the frame of the vehicle which incorporates a sensor providing feedback which controls the motor according to torque sensed through the secondary connection. The motor and associated gearing and control circuitry are housed within a wheel hub of which a drum supporting a wheel rim is supported at its inner surface on multiple bearings spaced around its periphery.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: December 17, 2002
    Inventor: Ervin Weisz
  • Patent number: 6495691
    Abstract: A process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives of general formula I: or their pharmaceutically acceptable salts, wherein the meaning of X is hydrogen, carboxyl, alkoxycarbonyl, aryloxycarbonyl, nitrile, or carbamoyl of formula wherein R1 and R2 can be individually or simultaneously hydrogen, alkyl or part of a heterocyclic structure; Z can be hydrogen, halogen, alkyl, aryl, aryloxy or alkoxy group.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: December 17, 2002
    Assignee: Brantford Chemicals Inc.
    Inventors: Stephen E. Horne, Gamini Weeratunga, Bogdan M. Comanita, Jaipal Reddy Nagireddy, Laura Kaye McConachie
  • Patent number: 6485744
    Abstract: Solid pharmaceutical compositions comprising cefuroxime axetil as active ingredient and a zinc salt as stabilizer.
    Type: Grant
    Filed: July 24, 2000
    Date of Patent: November 26, 2002
    Inventor: Bernard Charles Sherman
  • Patent number: D470749
    Type: Grant
    Filed: March 1, 1999
    Date of Patent: February 25, 2003
    Assignee: 420820 Ontario Limited
    Inventor: John Robert Davies