Patents Represented by Attorney Izumi Yokoyama, Esq.

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  • Human antibodies to human delta like ligand 4
    Patent number: 7534868
    Abstract: An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDII4) and blocks hDII4 binding to a Notch receptor. The human anti-hDII4 antibody or antibody fragment binds dimeric hDII4 with an affinity of 75 pM or better, as measured by surface plasmon resonance.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: May 19, 2009
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Nicholas J. Papadopoulos, Joel H. Martin, Eric Smith, Irene Noguera-Troise, Gavin Thurston