Abstract: The present invention relates compounds of the formula (I):
wherein
Z is —CR9R10CH2— or —CH2CR9R10—;
and R1, R2, R3, R4, R5 and R6 are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia.
Type:
Grant
Filed:
April 1, 2002
Date of Patent:
November 12, 2002
Assignee:
Merck Sharp & Dohme Ltd.
Inventors:
Ian Thomas Huscroft, Janusz Jozef Kulagowski, Piotr Antoni Raubo
Abstract: A growth hormone secretagogue is useful for enhancing the return of patients to independent living status following acute deconditioning such as that which may result from immobilization, surgery, or major injury such as hip fracture.
Type:
Grant
Filed:
August 31, 1999
Date of Patent:
February 27, 2001
Assignee:
Merck & Co., Inc.
Inventors:
Mark Bach, Vivian Fuh, Jennifer Ng, Alice Taylor