Patents Represented by Attorney, Agent or Law Firm Jaenelle S. Graeter
  • Bacteriohopanetetrol and related compounds useful for modulation of lipoxygenase activity and anti-inflammatory applications
    Patent number: 6177415
    Abstract: The arachidonic acid-metabolizing hopanoid tetrahydroxybacteriohopane (THBH) was isolated from Zymomonas mobilis and was found to inhibit soybean 15-lipoxygenase, and thus lipoxin biosynthesis, with an IC50 of about 10 &mgr;M. The activities of two other arachidonic acid-metabolizing enzymes, human 5-lipoxygenase (involved in prostaglandin biosynthesis) and prostaglandin H synthase, were unaffected by THBH. Subsequent studies showed that THBH was effective as an anti-inflammatory agent in topical applications.
    Type: Grant
    Filed: April 21, 1997
    Date of Patent: January 23, 2001
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Robert A. Moreau, Kevin B. Hicks