Patents Represented by Attorney James H. Callwood
  • Patent number: 5029115
    Abstract: An electronic prepress process for the preparation of camera-ready mechanicals for color printing. The process facilitates the integration of both visual and textual and both black and white and color inputs from various sources into a final set of output files which can be read by Page Description software as a process step in the creation of camera-ready mechanicals for printing.
    Type: Grant
    Filed: September 12, 1989
    Date of Patent: July 2, 1991
    Assignee: Laserfast Industries
    Inventor: Joel F. Geraci
  • Patent number: 4463016
    Abstract: The present disclosure is directed to a method of treating razor bumps which comprises administering to an individual suffering from razor bumps an effective amount of a 4-chloro-3,5-diloweralkylphenol compound in combination with a vehicle which facilitates topical application of said 4-chloro-3,5-diloweralkylphenol compound.
    Type: Grant
    Filed: September 22, 1982
    Date of Patent: July 31, 1984
    Assignee: Nel's Laboratory, Inc.
    Inventor: Nelson L. Burgess
  • Patent number: 4365070
    Abstract: The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.
    Type: Grant
    Filed: October 16, 1981
    Date of Patent: December 21, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert W. Guthrie, Richard W. Kierstead, Francis A. Mennona, Ann C. Sullivan
  • Patent number: 4361578
    Abstract: The invention is directed to 3-oxo-D-homosteroids and derivatives thereof which are useful as antiantigens.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: November 30, 1982
    Inventors: Leo Alig, Andor Furst, Peter Keller, Marcel Muller, Ulrich Kerb, Rudolf Wiechert
  • Patent number: 4360470
    Abstract: The present disclosure is directed to a process for the synthesis of chenodeoxychloic acid, 25-hydroxycholesterol and 1.alpha.,25-dihydroxycholesterol from 17-keto steroids. A cholic acid side chain is stereospecifically introduced by reaction of the appropriate 17-keto steroid with ethyltriphenylphosphonium halides to produce the 17-ethylidene derivative which is allowed to react with acrylic acid esters or propiolic acid esters followed by hydrogenation.
    Type: Grant
    Filed: October 22, 1980
    Date of Patent: November 23, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew D. Batcho, Milan R. Uskokovic, Peter M. Wovkulich
  • Patent number: 4354039
    Abstract: The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.
    Type: Grant
    Filed: September 21, 1981
    Date of Patent: October 12, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert W. Guthrie, Richard W. Kierstead, Francis A. Mennona, Ann C. Sullivan
  • Patent number: 4352758
    Abstract: The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.
    Type: Grant
    Filed: August 7, 1981
    Date of Patent: October 5, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert W. Guthrie, Richard W. Kierstead, Francis A. Mennona, Ann C. Sullivan
  • Patent number: 4341781
    Abstract: The present invention relates to pyridazopyridazine derivatives, a process for the preparation thereof, pharmaceutical preparations containing said derivatives and the use of said derivatives as antihypertensive agents.
    Type: Grant
    Filed: September 11, 1980
    Date of Patent: July 27, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Cedric H. Hassall, Christopher J. Moody
  • Patent number: 4340736
    Abstract: Aminoaryl esters and amino-lower alkyl amides of carboxy substituted barbiturates are linked via an amide linkage to carboxylated latex polymers to form reagents which are useful in a sensitive diagnostic test to detect the presence of barbiturates in body fluids.
    Type: Grant
    Filed: December 5, 1979
    Date of Patent: July 20, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Antonino Focella, John E. Heveran, Sidney Teitel, Manfred Weigele
  • Patent number: 4340754
    Abstract: The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.
    Type: Grant
    Filed: September 21, 1981
    Date of Patent: July 20, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert W. Guthrie, Richard W. Kierstead, Francis A. Mennona, Ann C. Sullivan
  • Patent number: 4330465
    Abstract: The solid-phase syntheses of [Ala.sup.2 ]-, [D-Leu.sup.2 ]-, [D-Lys.sup.2 ], [Leu.sup.5 ]- and [D-Ala.sup.2, D-Leu.sup.5 ] .beta.-endorphins are described. The synthetic peptides were purified by chromatography on carboxymethylcellulose and partition chromatography on Sephadex G-50. They were characterized by partition chromatography on agarose, thin-layer chromatography, paper electrophoresis, and amino acid analyses of acid and enzymic hydrolysates. Bioassay of the synthetic analogs for analgesic activity by the tail-flick-method showed the D-Leu.sup.2 analog to be 48% as potent as .beta..sub.h -endorphin while the Ala.sup.2, D-Lys.sup.2, Leu.sup.5, and [D-Ala.sup.2, D-Leu.sup.5 ] analogs were 8 to 17% as active.
    Type: Grant
    Filed: March 2, 1978
    Date of Patent: May 18, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Choh H. Li
  • Patent number: 4329281
    Abstract: Novel hapten compositions consisting of 4-[4-[2-(aminopropyl)]phenyl]butanoic acid and its N-methyl derivative are useful in preparing immunogens which can be respectively employed in the elicitation of antibodies selective to amphetamine and methamphetamine. These antibodies can be used as reagents in immunoassays for these two compounds.
    Type: Grant
    Filed: December 21, 1979
    Date of Patent: May 11, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: James G. Christenson, Benjamin Pecherer
  • Patent number: 4329488
    Abstract: Propionic acid esters of the general formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of from 1 to 6 carbon atoms or phenyl, R.sub.2 is alkyl of from 1 to 6 carbon atoms, alkenyl of from 2 to 6 carbon atoms, alkynyl of from 2 to 6 carbon atoms or phenyl, or R.sub.1 and R.sub.2 together with the carbon atom to which they are attached form a cycloalkane ring containing 4 to 10 carbon atoms which can be mono-, di- or trisubstituted with alkyl of from 1 to 3 carbon atoms, R.sub.3 represents a halogen, trifluoromethyl or nitro, and R.sub.4 and R.sub.5 each represent a hydrogen or halogen atom, processes for their manufacture, herbicidal compositions containing these compounds as the active ingredient and methods of use of the herbicidal compositions are disclosed.
    Type: Grant
    Filed: December 5, 1980
    Date of Patent: May 11, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Frater, Jean Wenger
  • Patent number: 4312885
    Abstract: The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.
    Type: Grant
    Filed: December 26, 1978
    Date of Patent: January 26, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert W. Guthrie, Richard W. Kierstead, Francis A. Mennona, Ann C. Sullivan
  • Patent number: 4312812
    Abstract: The present disclosure is directed to a process for the preparation of cholesterol derivatives from corresponding 21-hydroxymethyl steroidal compounds.
    Type: Grant
    Filed: January 19, 1981
    Date of Patent: January 26, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andor Furst, Ludwig Labler, Werner Meier
  • Patent number: 4310488
    Abstract: A tubular sample or reagent container for analytical devices, such as automated centrifugal analyzers, in which typically a multiplicity of such containers are arranged in a carrier plate or other means which forms part of the analyzers, with each container having a peripheral edge for bearing on the carrier plate. An abutment is provided on the containers disposed below the peripheral edge and at the periphery of the containers, which abutment is deformable in the centripetal direction.
    Type: Grant
    Filed: May 19, 1980
    Date of Patent: January 12, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jurg Rahm, Lothar Waltz
  • Patent number: 4310467
    Abstract: The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D.sub.3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via intermediates having the natural steroid configuration at the 20-position. These novel intermediates are prepared from 17-keto steroids by reaction with ethyltriphenylphosphonium halides followed by reaction with formaldehyde to form comounds having the natural steroid configuration at the 20-position and which are suitable substrates for the preparation of the aforementioned Vitamin D.sub.3 metabolites.
    Type: Grant
    Filed: October 22, 1980
    Date of Patent: January 12, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew D. Batcho, Donald E. Berger, Jr., Milan R. Uskokovic
  • Patent number: 4307094
    Abstract: The present disclosure is directed to 1-substituted or unsubstituted lower alkylene, 5-carboxy, alkanoyloxy or carbamoyloxy triazolopyridazine derivatives, salts of the acids and pharmaceutically-acceptable bases thereof. The triazolopyridazine derivatives provided by the present invention are useful as angiotensin-related antihypertensive agents.
    Type: Grant
    Filed: July 17, 1980
    Date of Patent: December 22, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Cedric H. Hassall, Christopher J. Moody
  • Patent number: 4301246
    Abstract: A multi-step synthesis of chenodeoxycholic acid from 3-keto-bisnorcholenol, a compound readily obtained from the abundant plant sterol .beta.-sitosterol, is described. A key step in the synthesis is the stereoselective microbial introduction of the 7-alpha hydroxy group into 3-keto-bisnorcholenol.
    Type: Grant
    Filed: January 18, 1980
    Date of Patent: November 17, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Carl Despreaux, Thomas A. Narwid, Norberto J. Palleroni, Milan R. Uskokovic
  • Patent number: 4292288
    Abstract: A method for the removal of CO from flue gas which comprises contacting a spent noble metal reforming catalyst with flue gas from a cat cracker regenerator at 1000.degree.-1350.degree. F. to effectively oxidize CO to CO.sub.2. The spent catalyst while no longer efficient in a reforming process is found to be effective in reducing the CO level to a concentration range of 5000 parts per million and less.
    Type: Grant
    Filed: October 18, 1977
    Date of Patent: September 29, 1981
    Assignee: Exxon Research & Engineering Co.
    Inventor: Elroy M. Gladrow