Patents Represented by Attorney, Agent or Law Firm James J. Sales
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Patent number: 8158616Abstract: The present invention relates to azetidine and cyclobutane derivatives, as well as their compositions, methods of use, and processes for preparation, which are JAK inhibitors useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.Type: GrantFiled: March 10, 2009Date of Patent: April 17, 2012Assignee: Incyte CorporationInventors: James D. Rodgers, Stacey Shepard
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Patent number: 8048861Abstract: The present invention relates to an active composition for controlling or eradicating Phthiraptera, Siphonaptera and Acarina Pests, typically in domestic animals, comprising a synergistic combination of at least one A83543 compound and at least one macrocyclic lactone. The invention also relates to the use of the active composition in pesticidal formulations, the formulations themselves and to the various applications of those formulations as pesticides, specifically in controlling all species of Phthiraptera, Siphonaptera and Acarina pests, typically in domestic animals. Such applications include the control of such external Phthiraptera, Siphonaptera and Acarina pests in domestic animals including but not limited to sheep, cattle, poultry, pigs, goats, camelids, horses, dogs and cats.Type: GrantFiled: April 9, 2010Date of Patent: November 1, 2011Assignee: Eli Lilly and CompanyInventors: Lionel Barry Lowe, James Terence Rothwell
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Patent number: 7943670Abstract: Described is a soluble stable liquid formulation, process for preparing, and a method of using the soluble stable liquid formulation comprising ractopamine or a physiologically acceptable salt thereof, a liquid nonionic cosolvent, and water.Type: GrantFiled: October 4, 2004Date of Patent: May 17, 2011Assignee: Eli Lilly and CompanyInventors: Michael David Burton, Sr., Paul Reuben Klink
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Patent number: 7897762Abstract: The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferrably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.Type: GrantFiled: September 12, 2007Date of Patent: March 1, 2011Assignee: Deciphera Pharmaceuticals, LLCInventors: Daniel L. Flynn, Peter A. Petillo, Michael D. Kaufman, William C. Patt
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Patent number: 7879809Abstract: This invention is directed to the use of spinosyn or a physiologically acceptable derivative or salt thereof for improved production of fish; controlling ectoparasite infestations in aquaculture raised fish; and fish feed formulations.Type: GrantFiled: May 15, 2006Date of Patent: February 1, 2011Assignee: Eli Lilly and CompanyInventors: Clayton Paul Dick, Daniel Earl Snyder, Joseph Raymond Winkle
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Patent number: 7803806Abstract: The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.Type: GrantFiled: November 2, 2006Date of Patent: September 28, 2010Assignee: SGX Pharmaceuticals, Inc.Inventors: William D. Arnold, Chixu Chen, Stefan N. Gradl, Stephanie A. Hopkins, Ruo W. Steensma, Masaki Tomimoto, Mark E. Wilson
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Patent number: 7772194Abstract: The present invention relates to an active composition for controlling or eradicating Phthiraptera, Siphonaptera and Acarina Pests, typically in domestic animals, comprising a synergistic combination of at least one A83543 compound and at least one macrocyclic lactone. The invention also relates to the use of the active composition in pesticidal formulations, the formulations themselves and to the various applications of those formulations as pesticides, specifically in controlling all species of Phthiraptera, Siphonaptera and Acarina pests, typically in domestic animals. Such applications include the control of such external Phthiraptera, Siphonaptera and Acarina pests in domestic animals including but not limited to sheep, cattle, poultry, pigs, goats, camelids, horses, dogs and cats.Type: GrantFiled: September 17, 2001Date of Patent: August 10, 2010Assignee: Eli Lilly and CompanyInventors: Lionel Barry Lowe, James Terence Rothwell
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Patent number: 7709447Abstract: A spinosyn or a physiologically acceptable derivative or salt thereof for promoting or accelerating wound healing in humans.Type: GrantFiled: April 29, 2004Date of Patent: May 4, 2010Assignee: Eli Lilly and CompanyInventors: Kristina Clare Hacket, Lionel Barry Lowe
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Patent number: 7109152Abstract: Use of a liquid composition for lubricating conveyor belts is provided, said liquid composition being suitable for producing a “dry” lubricant film on a surface by discontinuous application thereof, wherein the liquid composition can also be used for continuous application to a conveyor belt surface, with or without further dilution with water, to remove incidental spillages of extraneous material from the conveyor belt surface without loss of the required lubricity. This liquid composition was found to exhibit remarkably good durability.Type: GrantFiled: July 19, 2000Date of Patent: September 19, 2006Assignee: JohnsonDiversey, Inc.Inventors: Michael Peter Corby, Jeffrey Denton
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Patent number: 7013527Abstract: A floor cleaner is provided for cleaning a floor, where the floor cleaner has a front and a rear and includes: a sweeper for sweeping the floor, a scrubber, connected to the sweeper and located in the rear of the sweeper, for wetting and cleaning the floor; and a burnisher, connected to the scrubber and located in the rear of the scrubber, for burnishing the floor.Type: GrantFiled: September 3, 2004Date of Patent: March 21, 2006Assignee: JohnsonDiversey, Inc.Inventors: Victor W. Thomas, Sr., Robert K. Kay, Jayant Sharma, Phillip R. Mass, Rosario Robert, Colin Angle, Lee F. Sword, Joseph L. Jones, Paul E. Sandin, John P. O'Brien, Benjamin L. Wirz, Selma Slipichevich, Mark Chiappetta, Gideon Coltof
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Patent number: 6797719Abstract: This invention provides compounds of formula I and pharmaceutically acceptable salts and solvates thereof, characterized that the compound is in particulate form and having a specific size range. The present invention further provides pharmaceutical compositions containing or formulated using compounds of formula I, and the use of such compounds for alleviating human pathologies, including osteoporosis, serum lipid lowering, and breast cancer.Type: GrantFiled: September 5, 2002Date of Patent: September 28, 2004Assignee: Eli Lilly and CompanyInventors: Gordon Nelson Arbuthnot, Brian Weston Dalder, Kerry John Hartauer, Wayne Douglas Luke, Robert Eugene Stratford, Jr.
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Patent number: 6723739Abstract: A compound of the formula or a pharmaceutically acceptable salt or solvate thereof. Also provided by the invention are methods of use of the above compounds, and processes for the preparation thereof.Type: GrantFiled: March 15, 1995Date of Patent: April 20, 2004Assignee: Eli Lilly and CompanyInventors: Jeffrey A. Dodge, Charles A. Frolik, Terry D. Lindstrom, Charles W. Lugar, III
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Patent number: 6653328Abstract: This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzothiophenes which are &agr;-substituted with ether, thioether amino, cyano or halo that are useful for the treatment of the various medical indications associated with post-menopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus and cervix. The present invention further relates to intermediate compounds and processes useful for preparing the pharmaceutically active compounds of the present invention, and pharmaceutical compositions.Type: GrantFiled: March 10, 1995Date of Patent: November 25, 2003Assignee: Eli Lilly and CompanyInventor: Brian S. Muehl
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Patent number: 6562862Abstract: A method of inhibiting a physiological disorder associated with an excess of neuropeptide Y or its symptoms comprising administering to a human in need thereof an effective amount of a compound having the formula wherein R1 and R3 are independently hydrogen, or wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.Type: GrantFiled: October 20, 1994Date of Patent: May 13, 2003Assignee: Eli Lilly and CompanyInventors: Robert F. Bruns, Jr., Donald R. Gehlert, J. Jeffry Howbert, William H. W. Lunn
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Patent number: 6545027Abstract: A method of modulating NF-kB transcription factor comprising administering to a human in need thereof an effective amount of a compound having the formula wherein R1 and R3 are independently hydrogen, wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.Type: GrantFiled: June 7, 1995Date of Patent: April 8, 2003Assignee: Eli Lilly and CompanyInventors: David T. Berg, David S. Calnek, Brian W. Grinnell
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Patent number: 6509356Abstract: A class of substituted benzylnaphthylene compounds of the structure where R1 and R2 are independently hydrogen, alkyl of one to six carbon atoms, acyl of two to six carbon atoms, or phenacyl; X is —(CH2)1-6; Y is absent or is selected from 1,4-piperazinylene; ureido; N-(lower alkyl)ureido; N′-(lower alkyl)ureido; or N, N′-(di-lower alkyl ureido; and Z is 1-, 2- or 3-pyrrolidinyl; 1-, 2-, or 3-[1-(lower alkyl) pyrrolidinyl]; 1- 2-, 3- or 4-piperidinyl; 1-, 2-, 3- or 4-[1-lower alkyl)piperidinyl]; N,N-dialkyl; 1-azepinyl; 1- or 2-naphthylamino, 4-morpholinyl, dimethyl-4-morpholinyl, 3-azaspiro[5.Type: GrantFiled: August 4, 1998Date of Patent: January 21, 2003Assignee: Eli Lilly and CompanyInventors: Jeffrey Alan Dodge, Andrew Lawrence Glasebrook, Charles Willis Lugar, III
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Patent number: 6489355Abstract: This invention encompasses methods for the inhibition of a physiological disorder associated with amyloidogenic proteins, which method comprises administering to a human in need thereof an effective amount of a compound of Formula I wherein R1 and R3 are independently hydrogen, wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamthylenemino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.Type: GrantFiled: December 1, 1993Date of Patent: December 3, 2002Assignee: Eli Lilly and CompanyInventor: William H. W. Lunn
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Patent number: 6479517Abstract: This invention relates to the fields of pharmaceutical and organic chemistry and provides novel phosphorous-containing benzothiophene compounds which are useful for the treatment of the various medical indications associated with post-menopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus and cervix. The present invention further relates to intermediate compounds and processes useful for preparing the pharmaceutically active compounds of the present invention, and pharmaceutical compositions.Type: GrantFiled: February 28, 1995Date of Patent: November 12, 2002Assignee: Eli Lilly and CompanyInventors: Henry U. Bryant, Jeffrey A. Dodge, Jeffrey S. Nissen
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Patent number: 6458811Abstract: This invention provides compounds of formula I and pharmaceutically acceptable salts and solvates thereof, characterized that the compound is in particulate form and having a specific size range. The present invention further provides pharmaceutical compositions containing or formulated using compounds of formula I, and the use of such compounds for alleviating human pathologies, including osteoporosis, serum lipid lowering, and breast cancer.Type: GrantFiled: March 10, 1997Date of Patent: October 1, 2002Assignee: Eli Lilly and CompanyInventors: Gordon Nelson Arbuthnot, Brian Weston Dalder, Kerry John Hartauer, Wayne Douglas Luke, Robert Eugene Stratford, Jr.
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Patent number: 6436958Abstract: A method of inhibiting auto immune diseases comprising administering to a human in need thereof an effective amount of a compound having the formula wherein R1 and R3 are independently hydrogen, —CH3, or wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.Type: GrantFiled: May 19, 1995Date of Patent: August 20, 2002Assignee: Eli Lilly and CompanyInventor: Steven H. Zuckerman