Abstract: The present invention relates to novel 3,3-(disubstituted)cyclohexan-1-carboxylate monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).
Type:
Grant
Filed:
February 27, 1996
Date of Patent:
February 9, 1999
Assignee:
SmithKline Beecham Corporation
Inventors:
Siegfried B. Christensen, IV, Joseph M. Karpinski, M. Dominic Ryan, Paul E. Bender
Abstract: Retinoid-like activity is exhibited by compounds of the formula ##STR1## wherein A is pyridyl, furyl, thienyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, --COOH and its esters, amides and pharmaceutically acceptable salts, --CHO and its acetal derivatives, --COR.sub.1 and its ketal derivatives where R.sub.1 is --(CH.sub.2).sub.n CH.sub.3 where n is defined above, or --CH.sub.2 OH and its ether and acyl ester derivatives; or a pharmaceutically acceptable salt.
Abstract: A hydration device and kit are provided for effecting the hydration of a dehydrated soft contact lens resident within the cavity of a mold element in which the lens was formed.
Abstract: Achiral compounds of a 2H-pyran-2,6(3H)-dione derivative of the formula ##STR1## or a pharmaceutically acceptable salt thereof, where R is --(CH.sub.2).sub.m OH or --CH((CH.sub.2).sub.n CH.sub.2 OH).sub.2 where m is 1-5 and n is 0-4. These compounds are useful in the treatment of allergic conditions.
Type:
Grant
Filed:
September 10, 1986
Date of Patent:
February 16, 1988
Assignee:
Allergan, Inc.
Inventors:
Michael E. Garst, Charles Gluchowski, Lester J. Kaplan