Patents Represented by Attorney James W. Williams, Jr.

Find this attorney in the Justia Lawyer Directory

  • High efficiency column crystallizer
    Patent number: 4891191
    Abstract: An improved countercurrent solid-liquid contacting apparatus, and more particularly an improved counter-current crystallizer column is disclosed. The present invention embraces the discover that column efficiency and product purity can be substantially enhanced by reducing axial liquid back-mixing by using stationary solid beds and transport means at spaced intervals along the column length.
    Type: Grant
    Filed: May 1, 1985
    Date of Patent: January 2, 1990
    Assignee: Monsanto Company
    Inventors: Don E. Carter, Yung C. Hsu, Jason J. Tang
  • Monoclonal antibody specific for human colon fibroblast-derived T-PA
    Patent number: 4889922
    Abstract: A monoclonal antibody is disclosed which is specific for human colon fibroblast-derived tissue plasminogen activator (t-PA), and which is useful for immunoaffinity chromatography purification of t-PA and determination of t-PA in a biological sample.
    Type: Grant
    Filed: January 6, 1989
    Date of Patent: December 26, 1989
    Assignee: Monsanto Co.
    Inventors: Jon P. Schaumann, Jitka V. Olander, Nicholaos K. Hrakas, Joseph Feder
  • Large DNA cloning system based on yeast artificial chromosomes
    Patent number: 4889806
    Abstract: A large DNA cloning system is disclosed which is based on yeast artificial chromosomes. Cloning vectors are disclosed which allow the cloning of large segments of greater than 50 kb of exogenous DNA. The cloning vector comprises DNA sequences of an autonomous replication sequence, a centromere, a selectable yeast marker, two sequences that seed telomere function in vivo, and a cloning site within an interruptible yeast gene for insertion of the exogenous DNA segments.
    Type: Grant
    Filed: April 15, 1987
    Date of Patent: December 26, 1989
    Assignee: Washington University
    Inventors: Maynard V. Olson, David T. Burke
  • Novel platelet-aggregation inhibitors
    Patent number: 4879313
    Abstract: Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=6 to 10,y=0 to 4,Z=H, COOH, CONH.sub.2 or C.sub.1-6 alkyl,Ar=phenyl, biphenyl or napthyl, each substituted with 1 to 3 methoxy groups, or an unsubstituted phenyl, biphenyl, napthyl, pyridyl or thienyl group, andAsp=aspartic acid residue.
    Type: Grant
    Filed: July 20, 1988
    Date of Patent: November 7, 1989
    Assignee: Mosanto Company
    Inventors: Foe S. Tjoeng, Steven P. Adams
  • Process for producing 2,6-disubstituted tyrosine
    Patent number: 4879398
    Abstract: A process for making 2,6-disubstituted tyrosine by the noble metal coupling of a disubstituted aromatic halide or diazonium salt with an amino-protected 2-aminoacrylic acid to form a (Z)-.beta.-(disubstituted phenyl)-.alpha.-acylaminoacrylate, and asymmetrically hydrogenating the acrylate to produce the 2,6-disubstituted tyrosine.
    Type: Grant
    Filed: December 31, 1987
    Date of Patent: November 7, 1989
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Roy A. Periana, Dennis P. Riley
  • Antiviral compounds and use thereof
    Patent number: 4876268
    Abstract: Acylated derivatives of 1,4-dideoxy-1,4-imino-L-arabinitol and their N-alkyl and N-hydroxyalkyl derivatives in which all the free hydroxyl groups are acylated with acyl groups having from one to six carbon atoms and in which the N-alkyl substituents in the N-alkyl and N-hydroxyalkyl derivatives contain from one to fourteen carbon atoms are disclosed.
    Type: Grant
    Filed: November 3, 1988
    Date of Patent: October 24, 1989
    Assignee: G. D. Searle & Co.
    Inventors: Francis J. Koszyk, Richard A. Partis, Richard A. Mueller
  • Asymmetric hydrogenolysis of epoxides
    Patent number: 4870208
    Abstract: A process of preparing chiral alcohols by the asymmetric catalytic hydrogenolysis of epoxides using rhodium or ruthenium catalysts containing chiral phosphine ligands.
    Type: Grant
    Filed: June 3, 1988
    Date of Patent: September 26, 1989
    Assignee: Monsanto Company
    Inventors: Albert S. C. Chan, James P. Coleman, Grace M. Wagner
  • Novel antithrombin peptide
    Patent number: 4861865
    Abstract: A novel synthetic peptide with potent antithrombin activity is provided which has the following amino acid sequence: ##STR1##
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: August 29, 1989
    Assignee: Washington University
    Inventor: Glen L. Hortin
  • Method for synthesis of deoxymannojirimycin
    Patent number: 4861892
    Abstract: A method is disclosed for the chemical synthesis of 1,5-dideoxy-1,5-imino-D-mannitol or 1,5-dideoxy-1,5-imino-L-mannitol from, respectively, 2,3-O-isopropylidene-L-gulono-.gamma.-lactone or 2,3-O-isopropylidene-D-gulono-.gamma.-lactone which comprises carrying out interconversion between the L-gulono and D-mannono forms or between the D-gulono and L-mannono forms, respectively, and connecting of C-1 to C-5 by nitrogen.
    Type: Grant
    Filed: September 26, 1988
    Date of Patent: August 29, 1989
    Assignee: G. D. Searle & Co.
    Inventor: George W. J. Fleet
  • Novel platelet-aggregation inhibitor peptide derivatives
    Patent number: 4857508
    Abstract: Novel tetrapeptide derivatives are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the sequence X-Gly-Asp-Y wherein X is illustrated by arginine and Y is illustrated by O-methyltyrosine amide.
    Type: Grant
    Filed: December 3, 1987
    Date of Patent: August 15, 1989
    Assignees: Monsanto Company, G. D. Searle & Co.
    Inventors: Steven P. Adams, Larry P. Feigen, Masateru Miyano
  • Method of enhancing the solubility of tissue plasminogen activator
    Patent number: 4857320
    Abstract: The solubility of tissue plasminogen activator in aqueous solution is enhanced by incorporating therein arginine or a non-toxic salt of arginine in an amount effective to increase the solubility of the t-PA without substantially inhibiting its potential biological activity upon administration.
    Type: Grant
    Filed: February 19, 1987
    Date of Patent: August 15, 1989
    Assignee: Monsanto Company
    Inventor: Arthur J. Wittwer
  • Tumor diagnostic method
    Patent number: 4855241
    Abstract: An in vitro diagnostic method for determining the presence of nerve growth factor receptor bearing tumors is disclosed which comprises determining the presence of an elevated level of a truncated nerve growth factor receptor in a sample of a body fluid from a patient afflicted with such tumor.
    Type: Grant
    Filed: May 26, 1988
    Date of Patent: August 8, 1989
    Assignee: Washington University
    Inventor: Eugene M. Johnson, Jr.
  • Tissue plasminogen activator oligosaccharide from normal human colon cells
    Patent number: 4851517
    Abstract: Glycosylated plasminogen activator (t-PA) having a glycosylation pattern significantly different than exhibited by t-PA from Bowes melanoma cells is obtained from cultured normal human colon fibroblast cells (CCD-18Co).
    Type: Grant
    Filed: February 24, 1988
    Date of Patent: July 25, 1989
    Assignee: Monsanto Company
    Inventors: Joseph Feder, William R. Tolbert, Thomas W. Rademacher, Raj B. Parekh, Raymond A. Dwek
  • Method of inhibiting virus
    Patent number: 4849430
    Abstract: A method of inhibiting human immunodeficiency virus is disclosed which comprises administering to a patient infected with said virus a virally inhibitory effective amount of the N-butyl derivative of deoxynojirimycin or a pharmaceutically acceptable salt derivative thereof.
    Type: Grant
    Filed: September 23, 1988
    Date of Patent: July 18, 1989
    Assignee: Monsanto Company
    Inventors: George W. J. Fleet, Thomas W. Rademacher, Raymond A. Dwek
  • Monoclonal antibody specific for human colon fibroblast-derived t-PA
    Patent number: 4833085
    Abstract: A monoclonal antibody is disclosed which is specific for human colon fibroblast-derived tissue plasminogen activator (t-PA), and which is useful for immunoaffinity chromatography purification of t-PA and determination of t-PA in a biological sample.
    Type: Grant
    Filed: August 13, 1986
    Date of Patent: May 23, 1989
    Assignee: Monsanto Company
    Inventors: Jon P. Schaumann, Jitka V. Olander, Nicholaos K. Harakas, Joseph Feder
  • Solid state indicator electrode and method of making same
    Patent number: 4818365
    Abstract: A junction-type metal/metal oxide solid state indicator electrode wherein the sensing portion of the electrode is coated with a perfluorocarbon copolymer, and a pH sensor made of the indicator electrode and a reference electrode.
    Type: Grant
    Filed: October 14, 1986
    Date of Patent: April 4, 1989
    Assignee: Monsanto Company
    Inventors: Patrick J. Kinlen, John E. Heider
  • Process for the preparation of substituted olefins from unsaturated organic chlorides and olefins
    Patent number: 4814489
    Abstract: A process to prepare a substituted olefin involving reacting an unsaturated organic chloride with bromide and/or iodide ions to form a mixture of unsaturated organic chloride, bromide and/or iodide, and reacting the mixture with an olefin in the presence of a catalyst to form the substituted olefin.
    Type: Grant
    Filed: July 24, 1987
    Date of Patent: March 21, 1989
    Assignee: Monsanto Company
    Inventors: Joseph J. Bozell, Charles E. Vogt
  • Catalytic hydrodesulfurization of ortho-aminobenzylsulfides
    Patent number: 4806687
    Abstract: Ortho-alkylanilines are prepared by catalytic hydrodesulfurization of ortho-aminobenzyl sulfides using a cobalt-molybdenum oxide catalyst. For example, 2-methyl-6-trifluoromethylaniline is prepared by catalytic hydrodesulfurization of 3-trifluoromethyl-2-aminobenzyl sulfides. The substituted anilines prepared by the method of this invention are useful as intermediates in the synthesis of compounds shown to have herbicidal activity.
    Type: Grant
    Filed: September 30, 1987
    Date of Patent: February 21, 1989
    Assignee: Monsanto Company
    Inventors: Terry M. Balthazor, Samuel J. Tremont
  • Resin method for making sulfoxide for solid phase peptide synthesis
    Patent number: 4801665
    Abstract: A resin for solid phase peptide synthesis and a method for synthesizing the resin wherein the resin has a sulfoxide linkage which is stable to strong acid deprotecting conditions. The linkage can be reduced to a sulfide linkage which allows cleavage of the peptide from the resin under mild acid conditions.
    Type: Grant
    Filed: December 30, 1986
    Date of Patent: January 31, 1989
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Robert M. Heintz
  • Modified polymeric surfaces and process for preparing same
    Patent number: 4794002
    Abstract: A process for surface modifying a variety of polymeric support surfaces is disclosed in which a predetermined modifying polymer is irreversibly absorbed onto essentially all the surfaces of the support polymer accessible to the modifying polymer. The modifying polymer is selected to impart the desired surface characteristics to the modified polymeric surface.
    Type: Grant
    Filed: September 5, 1986
    Date of Patent: December 27, 1988
    Assignee: Monsanto Company
    Inventors: Jay M. Henis, Mary K. Tripodi, Donald I. Stimpson