Patents Represented by Attorney, Agent or Law Firm Janet Hasak
  • Methods and compositions for secretion of heterologous polypeptides
    Patent number: 6242177
    Abstract: The instant invention discloses the unexpected result that mutant signal sequences with reduced translational strength provided essentially complete processing and high levels of expression of a polypeptide of interest as compared to wild type signal sequences, and that many mammalian polypeptides require a narrow range of translation levels to achieve maximum secretion. A set of signal sequence vectors provides a range of translational strengths for optimizing expression of a polypeptide of interest.
    Type: Grant
    Filed: March 1, 1995
    Date of Patent: June 5, 2001
    Assignee: Genentech, Inc.
    Inventors: Laura C. Simmons, Daniel G. Yansura
  • Stoichiometric process for preparing a zeolite of the L type
    Patent number: 4657749
    Abstract: A zeolite of the L type is prepared by an approximately stoichiometric process wherein the zeolite is crystallized from a reaction mixture aged at from 80.degree. to 260.degree. C. containing specified ranges of molar ratios of KOH (and optionally a minor amount of NaOH), water, potassium silicate, and a source of alumina preferably derived from kaolin or halloysite. Most preferably, the source of alumina is metakaolin.
    Type: Grant
    Filed: May 13, 1986
    Date of Patent: April 14, 1987
    Assignee: Exxon Research and Engineering Company
    Inventor: David E. Vaughan
  • N-aminoalkyl alkylpiperazine promoted acid gas scrubbing process
    Patent number: 4581209
    Abstract: The present invention relates to an alkaline salt promoter system which includes an N-aminoalkyl alkylpiperazine, preferably the compound 1-(3-aminopropyl)-2,5-dimethylpiperazine (APDP), an alkali metal salt or hydroxide (e.g., K.sub.2 CO.sub.3) and water. These scrubbing compositions may be used for removing CO.sub.2 from gaseous streams containing CO.sub.2.
    Type: Grant
    Filed: October 3, 1983
    Date of Patent: April 8, 1986
    Assignee: Exxon Research and Engineering Co.
    Inventors: Alexis A. Oswald, Guido Sartori, David W. Savage, Warren A. Thaler
  • Process for preparing a zeolite of the L type using organic templates
    Patent number: 4554146
    Abstract: A zeolite of the L type is prepared by crystallization from a reaction mixture aged at 70.degree. to 260.degree. C. containing water, a source of silica or germania, a source of alumina or gallia, a source of potassium (and optionally up to 40 mole percent of a source of sodium, based on total mole percent of potassium and sodium), and a salt of a tetraalkylammonium cation wherein at least two alkyl groups have more than one carbon atom. Most preferably the cation is tetraethylammonium cation.
    Type: Grant
    Filed: November 10, 1983
    Date of Patent: November 19, 1985
    Assignee: Exxon Research and Engineering Co.
    Inventor: David E. Vaughan
  • Process for the selective removal of hydrogen sulfide from gaseous mixtures with severely sterically hindered secondary amino compounds
    Patent number: 4405581
    Abstract: The selective removal of H.sub.2 S gas from a normally gaseous mixture containing H.sub.2 S and CO.sub.2 is accomplished by contacting the gaseous mixture with an absorbent solution comprising a severely sterically hindered secondary amino compound having a cumulative .sup.- E.sub.s value (Taft's steric hindrance constant) greater than about 1.75 whereby H.sub.2 S is selectively absorbed from the mixture.
    Type: Grant
    Filed: January 18, 1982
    Date of Patent: September 20, 1983
    Assignee: Exxon Research and Engineering Co.
    Inventors: David W. Savage, Guido Sartori, Eugene L. Stogryn
  • Process for selective removal of H.sub.2 S from mixtures containing H.sub.2 .sub.2 with tertiary amino azabicyclic alcohols
    Patent number: 4405580
    Abstract: The selective removal of H.sub.2 S gas from a normally gaseous mixture containing H.sub.2 S and CO.sub.2 is accomplished by contacting the gaseous mixture with an absorbent solution comprising a tertiary amino azabicyclic alcohol whereby H.sub.2 S is selectively absorbed from the mixture.
    Type: Grant
    Filed: January 18, 1982
    Date of Patent: September 20, 1983
    Assignee: Exxon Research and Engineering Co.
    Inventors: Eugene L. Stogryn, David W. Savage, Guido Sartori
  • Severely sterically hindered tertiary amino compounds
    Patent number: 4405811
    Abstract: A novel class of severely sterically hindered tertiary amino compounds having a pK.sub.a value at 20.degree. C. greater than 8.6, preferably ranging from 9.3 to about 10.6, and a cumulative -E.sub.s value of at least 1.9 are found to be useful in selective removal of H.sub.2 S from a normally gaseous mixture containing H.sub.2 S and CO.sub.2.
    Type: Grant
    Filed: January 18, 1982
    Date of Patent: September 20, 1983
    Assignee: Exxon Research and Engineering Co.
    Inventors: Eugene L. Stogryn, Guido Sartori
  • Co-promoted acid gas scrubbing solution and process for using same
    Patent number: 4405578
    Abstract: The present invention relates to an alkaline salt promoter system comprising specific mixtures of lower aliphatic mono-substituted alpha amino acids and sterically hindered diamino or triamino compounds and their use in acid gas scrubbing processes. The preferred promoter system comprises a mixture of N-secondary butyl glycine and N-cyclohexyl-1,3-propanediamine or N-cyclohexyl-1, 4-butanediamine.
    Type: Grant
    Filed: November 13, 1981
    Date of Patent: September 20, 1983
    Assignee: Exxon Research and Engineering Co.
    Inventors: Guido Sartori, Warren A. Thaler
  • N-Secondary butyl glycine promoted acid gas scrubbing process
    Patent number: 4405586
    Abstract: The present invention relates to an alkaline salt promoter system which includes N-secondary butyl glycine and its use in acid gas scrubbing processes.
    Type: Grant
    Filed: November 13, 1981
    Date of Patent: September 20, 1983
    Assignee: Exxon Research and Engineering Co.
    Inventors: Guido Sartori, Warren A. Thaler