Abstract: The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae soluble protein and DNA molecules encoding such polypeptides, together with methods for their use in the diagnosis and treatment of mycobacterial infection. Methods for enhancing the immune response to an antigen including administration of M. vaccae culture filtrate or delipidated M. vaccae cells are also provided.

Abstract: A microwave electronics package has a microwave waveguide window assembly hermetically sealed to the electronics package using an intermediate bimetallic bushing. The metallic components of the bimetallic bushing have thermal properties similar to the thermal properties of the housing and waveguide window frame, respectively, permitting the use of fusion welding techniques such as laser welding to hermetically seal the waveguide assembly in the housing and to preserve the integrity of the waveguide window during fusion welding and during thermal cycling of the electronics package. A microwave grounding element is also provided in the assembled electronics package to provide a continuous microwave ground path.

Abstract: The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae protein and DNA molecules encoding such polypeptides, together with methods for their use in the diagnosis and treatment of mycobacterial infection. Methods for enhancing the immune response to an antigen including administration of M. vaccae culture filtrate or delipidated M. vaccae cells are also provided.

Abstract: Compositions derived from Gymnema sylvestre leaf materials are disclosed. Methods for isolating such compositions are also disclosed. The compositions may be administered orally, intravenously, subcutaneously or transdermally and are useful for treating patients having diabetes, impaired glucose tolerance, and various conditions associated with or symptoms of diabetes. Additionally, the compositions reduce polydipsia, polyuria and polyphagia, regenerate the pancreatic islets of Langerhans, including beta cells, increase endogenous insulin, lipase and amylase levels, increase production of proinsulin and c-peptide, and lower blood lipids and triglycerides and free fatty acids.

Abstract: There is disclosed a method for screening drug candidate compounds for anti-epileptic activity, a method for screening drug candidate compounds for activity to prevent or treat symptoms of Alzheimer's disease, and a method for determining cell viability and health of living cells inside polymeric tissue implants.

Abstract: An improved footwear closure system and composite liner are provided. The composite liner includes a first component that conforms closely to the upper in the area of the heel, toe and side portions of the upper, and a second, stretchable component that extends across and underneath the area between the split of the upper. The second, stretchable component may form an enlarged fold aligned generally with the centerline of the split of the upper. Both components of the composite liner are preferably constructed from a water-repellant or water-proof, breathable material. The composite liner cooperates with an improved closure system having two complementary strips mounted between the split of the upper and underlying the fasteners. When the closure system is drawn tight, any excess portion of stretchable component is collected between and outside the complementary strips, leaving a smooth surface on the inside of the upper in the area of the split and adjacent the instep.

Abstract: Methods for the treatment of skin disorders, including psoriasis, atopic dermatitis, allergic contact dermatitis, alopecia areata and skin cancers are provided, such methods comprising administering multiple doses of a composition having antigenic and/or adjuvant properties. Compositions which may be usefully employed in the inventive methods include inactivated M. vaccae cells, delipidated and deglycolipidated M. vaccae cells, M. vaccae culture filtrate and compounds present in or derived therefrom, together with combinations of such compositions.

Abstract: The present invention provides solutions and methods for preserving living biological materials that enable organs, tissues and cells to be stored for extended periods of time with minimal loss of biological activity. The inventive solutions are substantially isotonic with the biological material to be preserved and are substantially free of dihydrogen phosphate, bicarbonate, nitrate bisulfate and iodide. In one embodiment, the solutions comprise a first neutral solute having a molecular weight of at least about 335 and a solubility in water of at least about 0.3 M, a second neutral solute having a molecular weight of less than about 200 and having both hydrophilic and hydrophobic moieties, with the first neutral solute preferably being selected from the group consisting of raffinose and trehalose and the second neutral solute preferably being selected from the group consisting of trimethyl amine oxide and betaine.

Abstract: Novel isolated DNA sequences associated with the lignin biosynthetic pathway are provided, together with DNA constructs including such sequences. Methods for the modulation of lignin content in plants are also disclosed, the methods comprising incorporating one or more of the inventive DNA sequences or a sequence complementary to an inventive DNA sequence into the genome of a plant.

Abstract: Methods for treating non-insulin dependent Diabetes Mellitus (NIDDM), or Type II Diabetes, by administering a combination of treatment agents exhibiting glucocorticoid receptor type I agonist activity and glucocorticoid receptor type II antagonist activity are disclosed. Treatment agents having both glucocorticoid receptor type I agonist activity and glucocorticoid receptor type II antagonist activity are also disclosed. Screening methods for identifying compounds having both glucocorticoid receptor type I agonist activity and glucocorticoid receptor type II antagonist activity are disclosed.

Abstract: Regulatory DNA sequences that silence and enhance transcription of coding portions of the CD95 gene, which is instrumental in apoptosis, are disclosed. Proteinaceous transcription factors that bind to the silencer and enhancer regulatory sequences are also disclosed and are useful for modulating the expression of CD95 or other proteins. Methods for regulating apoptosis have therapeutic and prophylactic applications for a variety of disorders, including cancer, viral and retroviral infections, neurodegenerative disorders, immune system dysfunction, and other disorders.

Abstract: The present invention provides solutions and methods for preserving biological material that enable organs, tissues and cells to be stored for extended periods of time with minimal loss of biological activity. The inventive solutions are substantially isotonic with the biological material to be preserved and are substantially free of univalent oxyanions and of iodide. The solutions comprise a first neutral solute having a molecular weight of at least about 335 and a solubility in water of at least about 0.3M, and a second neutral solute having a molecular weight of less than about 200 and having both hydrophilic and hydrophobic moieties. The inventive solutions preferably contain CaSO.sub.4, together with combinations of anions and cations from the protein-stabilizing ends of the Hofmeister series, such as K.sub.2 SO.sub.4. Solutions with raffinose or trehalose in combination with trimethyl amine oxide or betaine are particularly preferred.

Abstract: The invention is an improved boiler for generating vapor at low pressure from liquid in reservoirs that are not pressurized. Liquid from a reservoir is fed through a supply wick by capillary action to a boiler wick in which the liquid is heated and boiled to a vapor. The heat for vaporization is transmitted by a porous hot seat which sits atop and is in contact with the boiler wick. The boiler wick and hot seat are contained within an insulating cylindrical shroud, which forms a tight seal with the edges of the boiler wick. If the liquid to be vaporized is a fuel for a burner, then combustion heat can be used to supply the heat to the boiler. A resistive heat source can also be used to heat the hot seat and boiler wick.

Abstract: Novel isolated DNA sequences associated with the lignin biosynthetic pathway are provided, together with DNA constructs including such sequences. Methods for the modulation of lignin content in plants are also disclosed, the methods comprising incorporating one or more of the inventive DNA sequences or a sequence complementary to an inventive DNA sequence into the genome of a plant.

Abstract: Methods for optically imaging blood flow changes, blood flow characteristics and changes in the oxygenation of blood in an area of interest are disclosed. The area of interest is illuminated with electromagnetic radiation(emr) in the visible or infrared regions of the spectrum, and a control image representative of the emr absorption of the area of interest is acquired. A subsequent image representative of the emr absorption is compared to the control image to detect changes in the emr absorption that are indicative of changes in blood flow, changes in blood flow characteristics, or changes in blood oxygenation in the area of interest.

Abstract: The present invention provides solutions and methods for preserving biological material that enable organs, tissues and cells to be stored for extended periods of time with minimal loss of biological activity. The inventive solutions are substantially isotonic with the biological material to be preserved and are substantially free of univalent oxyanions and of iodide. The solutions comprise a first neutral solute having a molecular weight of at least about 335 and a solubility in water of at least about 0.3M, and a second neutral solute having a molecular weight of less than about 200 and having both hydrophilic and hydrophobic moieties. The inventive solutions preferably contain CaSO.sub.4, together with combinations of anions and cations from the protein-stabilizing ends of the Hofmeister series, such as K.sub.2 SO.sub.4.

Abstract: Disclosed are topical anti-inflammatory compositions containing 0.1% to 10% by weight of a monogalactosyl dieicosapentaenoyl glycerol having esterified eicosapentaenoic acid residues (MGDG-EPA); anti-inflammatory compositions are formulated using a purified microalgal lipid preparation containing 30% to 100% by weight of MGDG-EPA; methods of making the microalgal lipid preparation; methods of treating inflammation by administering the topical anti-inflammatory compositions to a subject in need thereof.

Abstract: Gray scale ink jet printing method and apparatus produce a high quality image having varying color intensities. This is achieved by mixing a colored phase change ink with varying amounts of a clear phase change ink base, thereby producing multiple gray scale levels of each color. The mixing either can be performed prior to placement of the phase change ink in the printer, or can be performed within the printer to produce different levels of color intensity during the printing process.

Abstract: Expression vectors and methods for cloning amino-terminal signal sequences are disclosed. These vectors and methods are useful tools for cloning, identifying and isolating previously unknown signal sequences. In turn, an orphan signal sequence can be used to clone, identify and isolate the corresponding orphan proteins that the orphan signal sequence directs to the surface of a cell. Using these expression vectors and methods, an orphan protein can be cloned in the absence of a functional assay that detects such protein.