Patents Represented by Attorney Jeffery D. Frazier
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Patent number: 8235487Abstract: The present teachings relate to methods and apparatus for depositing one or more materials (e.g., one or more films, such as one or more solids) on one or more substrates, which may form part of an OLED or other type(s) of display. In some embodiments, the disclosure relates to apparatus and methods for depositing ink on one or more substrates. The apparatus can include, for example, one or more chambers for receiving ink, and plural orifices configured in the one or more chambers which are adapted for ejecting droplets of the ink; a discharge nozzle comprising an array of micro-pores (e.g., configured in a rectangular array), with each micro-pore having an inlet port and an outlet port, and the discharge nozzle receiving plural quantities (e.g., droplets) of ink from the chamber(s) via the orifices at the inlet ports and dispensing the ink from the outlet ports. The droplets of ink can be received at unique, spaced-apart locations on the inlet ports of the discharge nozzle.Type: GrantFiled: January 5, 2010Date of Patent: August 7, 2012Assignee: Kateeva, Inc.Inventors: Conor F. Madigan, Eliyahu Vronsky
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Patent number: 7968782Abstract: A flexible one-piece self-gripping self-forming-loop attachment, comprising a single ergonomically shaped and dimensioned strip of elastic material with circular apertures at opposing ends for attachment to a drumstick by inserting one end of the drumstick through each aperture in turn giving rise to a loop which is slid along the drumstick to the desired playing position at which a finger is inserted. When the loop is fitted the material surrounding the apertures stretches and causes their shape to change according to the profile of the drumstick.Type: GrantFiled: June 9, 2009Date of Patent: June 28, 2011Inventor: Kevin Mackie
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Patent number: 7798542Abstract: A door lock apparatus and methods are provided for preventing a child, or other unauthorized person, from opening an appliance (e.g., refrigerator) or cabinet door, while not unduly reducing or impeding access thereto by an authorized person, such as an adult. In various embodiments, the door lock apparatus is configured for locking in place outwardly swinging doors disposed in a side-by-side relationship. For example, a generally āUā or āVā shaped door lock can be adapted, when in a generally inverted orientation, to be slidably and removably received within channels or recesses formed by closely adjacent elongated handles of respective side-by-side doors. In some embodiments, the door lock apparatus can include, among other things, spaced legs depending from an upper support.Type: GrantFiled: November 28, 2007Date of Patent: September 21, 2010Inventors: Jeffery David Frazier, Kathleen Kostas Frazier, Leonard D. Bowersox
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Patent number: 6849127Abstract: The present invention provides a method and apparatus for dispensing a small volume of a selected liquid, such as a biological sample or reagent, onto a substrate. The device includes a tube adapted to contain the liquid. An elongate fiber is disposed within the tube for axial movement therein between raised and lowered positions. Upon shifting or oscillating the fiber between its raised and lowered positions, a liquid spot can be formed at a selected position on the substrate. The device is readily adaptable for the production of micro-arrays having a great number of individual spots.Type: GrantFiled: April 21, 2003Date of Patent: February 1, 2005Assignee: Applera CorporationInventors: Charles S. Vann, Zbigniew Bryning
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Patent number: 6821402Abstract: The invention relates to methods, compositions, and systems for calibrating a fluorescent polynucleotide separation apparatus. One aspect of the invention is multiple color calibration standards and their use. A multiple color calibration standard is a mixture of at least two polynucleotides of different length, wherein each of the polynucleotides is labeled with a spectrally distinct fluorescent dye. Another aspect of the invention is to produce total emission temporal profiles of multiple color calibration standards for use in calibrating fluorescent polynucleotide separation apparatus. The peaks corresponding to the fluorescently labeled polynucleotides in the total emission temporal profile may be detected using a peak detector that is driven by changes in the slopes of the total emission temporal profile.Type: GrantFiled: September 16, 1998Date of Patent: November 23, 2004Assignee: Applera CorporationInventors: Muhammad A. Sharaf, Maria C. Roque-Biewer
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Patent number: 6632660Abstract: The present invention provides, among other things, supports upon which one or more species can be adsorbed, captured, or immobilized for biochemical procedures. In various embodiments, the supports include a plurality of deformable petal-like members that provide binding sites for biochemical species. The invention provides an apparatus and method for the ready insertion of the petal-like members into respective wells of a multi-well microplate (e.g., a standard-format 96- or 384-well plate).Type: GrantFiled: January 4, 2002Date of Patent: October 14, 2003Assignee: Applera CorporationInventor: Paul O. Ramstad
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Patent number: 6627433Abstract: A side-entry excitation arrangement is provided with a multi-channel analyte-separation device. In various embodiments, a plurality of channels are disposed in an array, with a laser disposed to direct an excitation beam of light along a beam path that crosses the longitudinal axes of the channels, so as to simultaneously irradiate a region of each of the channels. Devices of the invention can be useful, for example, in the separation and analysis of bio-molecules, such as DNA, RNA, etc.Type: GrantFiled: August 24, 2001Date of Patent: September 30, 2003Assignee: Applera CorporationInventors: Jeffery D. Frazier, Paul D. Grossman
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Patent number: 6579367Abstract: The present invention provides a method and apparatus for dispensing a small volume of a selected liquid, such as a biological sample or reagent, onto a substrate. The device includes a tube adapted to contain the liquid. An elongate fiber is disposed within the tube for axial movement therein between raised and lowered positions. Upon shifting or oscillating the fiber between its raised and lowered positions, a liquid spot can be formed at a selected position on the substrate. The device is readily adaptable for the production of micro-arrays having a great number of individual spots.Type: GrantFiled: July 30, 2002Date of Patent: June 17, 2003Assignee: Applera CorporationInventors: Charles S. Vann, Zbigniew Bryning
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Patent number: 6537433Abstract: A method is disclosed for effecting the concentration of a polar analyte in an alternating electric field. In the method, a relative translation of the polar analyte and an alternating electric field along a translation path is effected. A portion of the polar analyte is then trapped and concentrated in a concentration zone formed by the intersection of the translation path and the alternating electric field. Also disclosed are various devices for carrying out the forgoing method.Type: GrantFiled: March 10, 2000Date of Patent: March 25, 2003Assignee: Applera CorporationInventors: Zbigniew T. Bryning, Theresa B. Taylor
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Patent number: 6484328Abstract: The present invention provides a device and method for improved toilet hygiene. One aspect of the present invention provides an improved toilet seat cover having an affinity for a toilet seat. Another aspect of the present invention provides a method for rendering a toilet seat cover in a state wherein the cover possesses an affinity for a toilet seat. Such affinity can be established in a variety of ways, including by way of disparate surface charges (e.g., by triboelectric charging).Type: GrantFiled: May 3, 2001Date of Patent: November 26, 2002Inventor: Jeffery D. Frazier
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Patent number: 6467700Abstract: The present invention provides a method and apparatus for dispensing a small volume of a selected liquid, such as a biological sample or reagent, onto a substrate. The device includes a tube adapted to contain the liquid. An elongate fiber is disposed within the tube for axial movement therein between raised and lowered positions. Upon shifting or oscillating the fiber between its raised and lowered positions, a liquid spot can be formed at a selected position on the substrate. The device is readily adaptable for the production of micro-arrays having a great number of individual spots.Type: GrantFiled: March 20, 2001Date of Patent: October 22, 2002Assignee: PE Corporation (NY)Inventors: Charles S. Vann, Zbigniew Bryning
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Patent number: 6413586Abstract: The present invention provides a method and apparatus for dispensing a small volume of a selected liquid, such as a biological sample or reagent, onto a substrate. The device includes a tube adapted to contain the liquid. An elongate fiber is disposed within the tube for axial movement therein between raised and lowered positions. Upon shifting or oscillating the fiber between its raised and lowered positions, a liquid spot can be formed at a selected position on the substrate. The device is readily adaptable for the production of micro-arrays having a great number of individual spots.Type: GrantFiled: March 20, 2001Date of Patent: July 2, 2002Assignee: PE Corporation (NY)Inventors: Charles S. Vann, Zbigniew Bryning
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Patent number: 6245297Abstract: The present invention provides a method and apparatus for dispensing small volumes of selected substances, such as biological reagents or samples, onto substrates. According to one general embodiment, a plurality of spaced, tandemly-arranged substrates are advanced, e.g., by way of a conveyor, along a transport pathway extending over a reagent-supply location, such as a reservoir supported at a fixed position in a base. From a position over the reagent-supply location and the pathway, a reagent-transfer instrument, or tip, is extended along an axis through an intervening region, e.g., an opening defined by a surface of the conveyor, separating an adjacent pair of advancing substrates to contact reagent held at the reagent-supply location. The reagent-transfer instrument is then withdrawn, along with a portion of such reagent, through the intervening region to a position above the transport pathway.Type: GrantFiled: April 16, 1999Date of Patent: June 12, 2001Assignee: PE Corporation (NY)Inventor: Reid Burton Kowallis
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Patent number: 6197579Abstract: Disclosed is a cell washing device and method of washing cells that utilizes the device. The device is particularly designed for sterile transfer of cells from a primary centrifuge tube and for maintaining the cells in a sterile environment during subsequent washing steps. The device is configured to provide for decantation of a supernatant by inversion without appreciable loss of a selected population of lower density cells from the pellet during the washing procedure.Type: GrantFiled: July 17, 1998Date of Patent: March 6, 2001Assignee: Dendreon CorporationInventors: Peter Van Vlasselaer, Shirin W. Hasan
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Patent number: 6142164Abstract: One aspect of the present invention provides an apparatus which permits the efficient purging of leaked process gas at the component-panel interface in an integrated gas panel system. The apparatus provides conduit structure for directing a flow of purging gas through a surface interface whereat a gas-manifold panel meets gas-manifold components. A further aspect of the invention provides a method for efficiently purging process gas which might leak out at the component-panel interface in an integrated gas panel system. The method includes the step of simultaneously directing a stream of purging gas along a pathway extending over the surface interface and along a pathway which intersects and passes through the surface interface.Type: GrantFiled: March 9, 1998Date of Patent: November 7, 2000Assignee: Ultra Clean Technology Systems & Service, Inc.Inventors: Bruce C. Wier, Akira Muraoka, Charles K. Lokey
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Patent number: 6132996Abstract: A thermocycling apparatus comprising a plurality of capillaries for moving DNA-containing samples between two or more discrete zones maintained at selected elevated temperatures.Type: GrantFiled: February 8, 1999Date of Patent: October 17, 2000Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventor: Scott P. Hunicke-Smith
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Patent number: 5978091Abstract: An apparatus for measuring the height and diameter of laser-zone texture bumps on a rigid magnetic disk substrate is disclosed. The apparatus has a disk holder for supporting and rotating the substrate, and an optical beam-source assembly for directing a focused laser beam on the substrate, and for shifting the position of the beam's illumination spot on the substrate in a tracking (radial) direction. An optical detection assembly in the apparatus measures the deflection of the laser beam due to specular reflection of the beam by laser-zone texture bumps, as a function of time, in both scanning (circumferential) and tracking directions.Type: GrantFiled: June 26, 1998Date of Patent: November 2, 1999Assignee: HMT Technology CorporationInventors: Peter C. Jann, Marco A. Krumbuegel, Reginald Lee, Ming M. Yang
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Patent number: 5810648Abstract: A texturing device for texturing a disc substrate of the type used in forming a thin-film medium is described. The device includes a rotatable assembly having a first pad attached to one end of a spindle and an annular ring having a second pad attached on one surface. Each pad defines a texturing surface for texturing the inner and outer regions of the disc substrate.Type: GrantFiled: March 5, 1997Date of Patent: September 22, 1998Assignee: HMT Technology CorporationInventors: Zhaoguo Jiang, Ming M. Yang, James L. Chao, Bruce M. Harper, Michael A. Russak