Patents Represented by Attorney Jennifer L. Fox

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  • Pyrimidineamines as angiogenesis modulators
    Patent number: 7105530
    Abstract: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also Includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: September 12, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Amogh Boloor, Mui Cheung, Ronda Davis, Philip Anthony Harris, Kevin Hinkle, Robert Anthony Mook, Jr., Jeffery Alan Stafford, James Marvin Veal
  • Thiazole derivatives for treating PPAR related disorders
    Patent number: 7105551
    Abstract: The present invention provides compounds of formula (I).
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: September 12, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Rodolfo Cadilla, Romain Luc Marie Gosmini, Millard Hurst Lambert, III, Michael Lawrence Sierra
  • Furan and thiophene derivatives that activate human peroxisome proliferator activated receptors
    Patent number: 7091237
    Abstract: A compound of formula (I) or pharmaceutically acceptable salts and solvates thereof, for the treatment of a hPPAR mediated disease or condition
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: August 15, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Paul John Beswick, Christopher Charles Hamlett, Vipulkumar Patel, Michael Lawrence Sierra, Nigel Grahame Ramsden
  • Substituted oxazoles and thiazoles as hPPAR alpha agonists
    Patent number: 7091225
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof wherein X is O or S X1 is O or S; X is S or O; R1 and R2 are independently H, methyl, or halogen; R4 and R5 are independently H or C1-3 alkyl or R4 and R5 may, together with the carbon atom to which they are bonded, form a 3–5 membered cycloalkyl ring; R6 and R7 are independently H, C1-3 alkyl, or allyl; each R3 is independently halogen, C1-6 straight or branched alkyl, or CF3; and y is 0, 1, 2, 3, 4 or 5 act as hPPAR alpha agonists.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: August 15, 2006
    Assignee: SmithKline Beecham Corporation
    Inventor: Michael Lawrence Sierra
  • Method for treating inflammatory diseases or conditions
    Patent number: 7084161
    Abstract: A method of treating inflammatory diseases comprising administering 2-[2-methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methyl]sulfanyl]phenoxy]acetic acid is disclosed.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: August 1, 2006
    Assignee: SmithKlineBeecham Corporation
    Inventor: Kevin William Buchan
  • Compounds for inhibiting insulin secretion and methods related thereto
    Patent number: 6958352
    Abstract: Compounds, compositions and methods for altering insulin secretion, particularly in the context of treatment of subjects having, or suspected of being at risk for having, diabetes mellitus. The compounds have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein W1, W2, X, R1, R2, R3, R4, m and n are defined herein.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: October 25, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Yazhong Pei, Soumitra S. Ghosh, Ian William James
  • Methods for preparing pharmaceutical formulations
    Patent number: 6911455
    Abstract: The invention relates to pharmaceutical formulations and methods for preparing pharmaceutical formulations of histamine releasers. The present invention provides methods for determining the concentration of physiologically acceptable excipients for use in the formulations of the invention. The present invention also provides methods for suppressing pharmaceutically-induced histamine release by administering to an animal, the formulations of the present invention. A kit useful for preparing pharmaceutical formulations of histamine releasers is also provided.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: June 28, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Alison G. Floyd, Mir A Hashim, Peiyuan Lin, Robert A. Mook, Andrea Sefler, Kathleen Cornell Meserve, Patricia Neal Ricciarelli, Timothy David Spitzer