Abstract: This invention relates to 4-aryloxy-1,2,3,4-tetrahydroisoquinolines of the formula ##STR1## where Y is hydrogen and alkoxy; X is hydrogen, cyano, benzoyl, trifluoromethyl, phenyl, halogen, alkyl alkoxy and nitro; R is hydrogen and alkyl; R.sub.1 is hydrogen, alkyl, aralkyl, ##STR2## and Co.sub.2 R.sub.4 where R.sub.4 is aryl and alkyl; R.sub.2 and R.sub.3 are the same or different and are hydrogen and alkyl or R.sub.2 and R.sub.3 are fused together to form a pyrrolidino or a piperidino ring substituent; and m is an integer of 1 or 2; n is an integer of 2 or 3; and a pharmaceutically acceptable acid addition salt thereof.

Abstract: This invention relates to substituted 4,10-dihydro-10-oxothieno benzoxepins of the formula, ##STR1## where R is hydrogen and lower alkyl; R.sub.1 is ##STR2## where R.sub.2 is hydrogen, lower alkyl and benzyl of the formula ##STR3## where X is hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, nitro, and amino; ##STR4## where R.sub.3 and R.sub.4 are the same or different and are hydrogen and lower alkyl; ##STR5## where R.sub.5 and R.sub.6 are the same or different and are lower alkyl; and the pharmaceutically acceptable acid addition salts thereof.

Abstract: An immunoadsorbent material comprising inactivated, protein-A bearing Staphlococcus aureus immobilized in a polymeric matrix is used to remove IgG immunoglobulins and immune complexes from whole blood.

Abstract: The invention relates to compounds of the formula ##STR1## where Y is --OH; halogen; ##STR2## where R.sub.1 is a straight chain or branched chain alkyl group having 1 to 5 carbon atoms, or aryl; and R.sub.2 is --C(CH.sub.3).sub.3 or --O--C(CH.sub.3).sub.3. Processes for preparing the compounds are provided. The compounds are useful as intermediates in the preparation of 4-phenyl-1,3-benzodiazepins, which exhibit activity as antidepressants, analgetics and anticonvulsants.

Abstract: This invention relates to pyrrolylaminopiperidines and related compounds of the formula ##STR1## where R is hydrogen, loweralkyl, Arloweralkyl, cycloalkylloweralkyl, loweralkenyl and thienylloweralkyl; R.sub.1 is lower alkyl, hydrogen, loweralkylcarbonyl, loweralkoxycarbonyl, loweralkylthiocarbonyl of the formula ##STR2## cyano, loweralkylaminocarbonyl, diloweralkylaminocarbonyl, cycloalkylcarbonyl, cycloalkylloweralkylcarbonyl and loweralkenylcarbonyl; R.sub.2 is hydrogen, halogen and methyl; and the pharmaceutically acceptable acid addition salts thereof.

Abstract: The invention relates to 1-(aminoalkylphenyl and aminoalkylbenzyl)indoles and indolines of the formula: ##STR1## where R.sub.1 and R.sub.2 are the same or different and are hydrogen, lower alkyl, cycloalkyl and acyl of the formula ##STR2## where R.sub.3 is lower alkyl, lower alkoxy, cycloalkyl, phenyl of the formula ##STR3## and Ar lower alkyl of the formula ##STR4## X is hydrogen, halogen, lower alkoxy, Ar lower alkoxy of the formula ##STR5## m and p are independently integers of 0 and 1 and the pharmaceutically acceptable acid addition salts thereof.

Abstract: This invention relates to substituted 1-azaspiro[4.5] decanes and 1-azaspiro[5.5]undecanes of the formula ##STR1## wherein R.sub.1 is hydrogen, --CO.sub.2 R.sub.4, R.sub.4 ; R.sub.2 is hydrogen, ##STR2## R.sub.3 is hydrogen, ##STR3## R.sub.4 is alkyl of 1 to 4 carbon atoms; R.sub.5 is alkyl of 1 to 8 carbon atoms; X is halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, CF.sub.3, and OH; m is an integer of 0, 1 or 2; and n is an integer of 1 or 2.

Abstract: This invention relates to 1'-[3-(1,2-benzisoxazol-3-yl)propyl]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines] of the formula: ##STR1## where X and Y are the same or different and are hydrogen, halogen, lower alkoxy, lower alkyl, nitro, hydroxyl and CF.sub.3 ; and n is an integer of 1 or 2; m is an integer of 2 or 3; and the sum of m and n is 3 or 4; and the pharmaceutically acceptable acid addition salts thereof. These compounds are useful as antihypertensive agents.

Abstract: 2'-Substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and methods of preparing same are described. On the aromatic portion of the benzofuran ring, there may be a substituent or substituents including halogen, amino, lower-alkyl-substituted amino, lower alkyl, lower alkoxy, hydroxy and nitro. The substituents at the 2-position of the cyclohexane ring are --(CH.sub.2).sub.n NR.sup.1 R.sup.2 where n is 0, 1 or 2 and R.sup.1 and R.sup.2 are each independently hydrogen and alkyl of 1-3 carbons. These compounds are useful as antidepressants and analgesics.Various other compounds which are useful as intermediates for preparing the aforementioned compounds and methods for preparing same are also described.

Abstract: This invention relates to 4-aryloxy-1,2,3,4-tetrahydroisoquinolines of the formula ##STR1## , where Y is hydrogen and alkoxy; X is hydrogen, cyano, benzoyl, trifluoromethyl, phenyl, halogen, alkyl alkoxy and nitro; R is hydrogen and alkyl; R.sub.1 is hydrogen, alkyl, aralkyl, ##STR2## and CO.sub.2 R.sub.4 where R.sub.4 is aryl and alkyl; R.sub.2 and R.sub.3 are the same or different and are hydrogen and alkyl or R.sub.2 and R.sub.3 are fused together to form a pyrrolidino or a piperidino ring substituent; and m is an integer of 1 or 2; n is an integer of 2 or 3; and a pharmaceutically acceptable acid addition salt thereof.

Abstract: Novel (1,2-benzisoxazol)phenoxyacetic acids and related compounds, methods for preparing same and methods of treatment by administering compositions containing such a compound are described. These compounds are useful as diuretics.

Abstract: The invention relates to diuretic dihydro-dibenzoxepines-thiepines and -morphanthridones of the formula ##STR1## wherein R is ##STR2## where R.sup.4 is a hydrogen or an alkyl; R.sup.1 is hydrogen or alkyl; R.sup.2 and R.sup.3 are the same or different and are hydrogen, alkyl or R.sup.2 and R.sup.3 are fused to form a pyrrolidino, morpholino, piperidino or azepino ring substituent; Y is hydrogen, halogen and alkoxy, X is ##STR3## where R.sup.4 is as defined above; m is an integer of 0 or 1; and n is an integer of 2 or 3; and the pharmaceutically acceptable acid addition salts thereof.

Abstract: The invention relates to spiro[dihydrobenzofuran-piperidines and -pyrrolidines] of the formula ##STR1## wherein R is the hydrogen atom, alkyl, alkoxycarbonyl, phenoxycarbonyl, cyano, and alkyl, alkanoyl, aralkanoyl, hydroxyalkyl, benzoylalkyl, ##STR2## where p is an integer of 2 or 3 and R.sub.1 and R.sub.2 are the same or different and are hydrogen and alkyl; X is hydrogen and alkyl; Hal is a halogen and q is an integer of 0 or 1; m is an integer of 1 or 2, n is an integer of 1, 2 or 3, where the sum of m and n is 3 or 4; and the pharmaceutically acceptable acid addition salts thereof.

Abstract: A neuroleptic agent is disclosed. The agent is 3-{3-[4-(4-fluorobenzoyl)piperidyl]propyl}-2-methylindole or an acid addition salt thereof prepared from a pharmaceutically acceptable acid.

Abstract: Compounds of the formula ##STR1## wherein Y is halogen; R is hydrogen, alkyl, alkoxycarbonyl, phenoxycarbonyl, cyano, aralkyl, alkanoyl, aralkanoyl, hydroxyalkyl, benzoylalkyl, ##STR2## where p is an integer of 2 or 3; and R.sub.1 and R.sub.2 are the same or different and are hydrogen and lower alkyl; X is hydrogen and alkyl; Hal is a halogen; q is an integer of 0 or 1; m is an integer of 1 or 2 and n is an integer of 1, 2 or 3, where the sum of m and n is 3 or 4; and a pharmaceutically acceptable acid addition salt thereof, are provided. The compounds are useful intermediates in the preparation of Spiro[dihydrobenzofuran-piperidines and pyrrolidines], which are useful agents for relieving pain and for lowering blood pressure.

Abstract: (Arylmethyl)phenyl-aminocyclohexanols, (arylmethyl)phenyl aminocyclohexenes and (arylmethyl)phenyl-aminocyclohexanes and methods of preparing same are described. These compounds are useful as antidepressants and anticonvulsants.Compounds 8-[2-(phenylmethyl)phenyl]-1,4-dioxaspiro[4,5]-decan-8-ol, 1-[2-(phenylmethyl)phenyl]-4-oxocyclohexanol, and 1-[2-(phenylmethyl)phenyl]-4-oxocyclohexanol oxime, and methods of preparing same are also described. These compounds are useful as intermediates for preparing the antidepressant and anticonvulsant compounds.

Abstract: A method of preparing substituted acylbenzenes is disclosed. The method comprises reacting selected acylhalides or equivalents with a selected poly-substituted benzene in the presence of an acylating catalyst comprising a clay.

Abstract: The invention relates to spiro[dihydrobenzofuran-piperidines and -pyrrolidines] of the formula ##STR1## wherein R is the hydrogen atom, alkyl, alkoxycarbonyl, phenoxycarbonyl, cyano, aralkyl, alkanoyl, aralkanoyl, hydroxyalkyl, benzoylalkyl, ##STR2## where p is an integer of 2 or 3 and R.sub.1 and R.sub.2 are the same or different and are hydrogen and alkyl; X is hydrogen and alkyl; Hal is a halogen and q is an integer of 0 or 1; m is an integer of 1 or 2, n is an integer of 1, 2 or 3, where the sum of m and n is 3 or 4; and the pharmaceutically acceptable acid addition salts thereof.