Abstract: The invention provides a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, specifically cancer. Cell proliferation associated with aberrant expression of MUC1 is particularly focused upon. Mechanisms associated with MUC1 cell proliferation are discussed.

Abstract: The present application discloses a method of treating a disease that is treatable by therapeutic angiogenesis comprising administering to a needy subject an effective amount of a chimeric coiled coil molecule comprising a coiled-coil domain linked to a receptor binding domain of a ligand.

Abstract: The present application discloses a pharmaceutical composition for treating Parkinson's disease and psychotropic intoxication/abusive potential, which contains a morphinan compound.

Abstract: The present application describes a fusion molecule that includes coiled coil domain, which renders the molecule soluble and provides potent activity.

Abstract: The present invention relates to a method for analyzing the interaction between HIF-1 peptide and VBC protein using fluorescence polarization, more precisely, a method for quantitative analysis of formation of HIF-1-VBC protein complex which is composed of the steps of 1) preparing a fluorescent probe by attaching a fluorescein to hydroxyproline containing HIF-1 peptide; 2) reacting the fluorescent probe with VBC protein; and 3) measuring the fluorescence polarization of the above reactant and then comparing the fluorescence polarization with that of the fluorescent probe itself to investigate the changes of fluorescence polarization; a method for screening an inhibitor of the binding of HIF-1 peptide and VBC protein using the above method; and a method for analyzing the activity of prolyl hydroxylase using the above method.

Abstract: Disclosed herein is a driving device of armature balance machine, in which a driving motor is formed on the same centerline of the armature, a hinge block pivot-connected by the hinge shaft is installed in the finger mounter of the bracket in such a manner that the hinge shaft is disposed on the same centerline of the driving motor and the variable roller is formed at one side of the hinge shaft, the finger provided with a complementary roller is symmetrically constructed about the centerline of the driving motor, and thereafter a belt is wound around each roller, so that the construction of the driving motor can be simplified and thus the length of the belt is minimized and the vibration of the belt is minimized, thereby enabling to keep the tension applied to the belt in an optimum state, due to the facts that the tension of the belt is symmetrical about the centerline of the belt and also the variable roller i.e. the tension adjusting means is not operated by the belt.

Abstract: The present invention relates to a cell line in which a potassium channel is introduced. More specifically, it is a cell line capable of activating the T-type ?1H calcium channel by depolarization wherein a vector encoding a potassium channel is introduced. Since the cell line of the present invention is available for a high throughput screening of candidate T-type ?1H calcium channel inhibitors, it may accelerate the development of therapeutic agents for diseases related to T-type ?1H calcium channels.

Abstract: The present application discloses W-rich peptide that is useful for inhibiting FPR class receptor activity.

Abstract: The present invention relates to a monoclonal antibody that specifically binds to vascular cell adhesion molecule-1 (VCAM-1 or CD106). Specifically, the present invention relates to an antibody that specifically binds to both human and mouse vascular cell adhesion molecule-1 (VCAM-1), a method for producing the same, a composition for diagnosis or treatment comprising them and a method for diagnosis or treatment using them. The monoclonal antibody of the present invention is the first recombinant monoclonal antibodies that is specific to human and mouse VCAM-1. In addition, the monoclonal antibody of the present invention shows a strong affinity to VCAM-1 expressed in rat skeletal muscle and porcine endothelial cells as well as human and mouse endothelial cells and is found to strongly inhibit the interaction between leukocytes and activated endothelial cells.

Abstract: The present invention provides a nucleic acid sequence amplification method and apparatuses thereof that are simple in the design and easy to miniaturize and integrate into complex apparatuses, with capability of using DNA polymerases that are not thermostable. In the present invention, a plurality of heat sources are combined to supply heat to, or remove heat from specific regions of the sample such that a specific spatial temperature distribution is maintained inside the sample by locating a relatively high temperature region lower in height than a relatively low temperature region.

Abstract: The invention shows the effective input of a target word or phrase by applying a Full Input Method and by using an index storing full code. In addition, this invention proposes an input system for inputting various objects (alphabet characters, special characters, functions, etc) by combination of a long stroke of a button and a short stroke of the button, and by combination of a long stroke of a button and a short stroke of a control button.

Abstract: The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novel Mytilus galloprovincialis foot protein type 5 (MGFP-5) and a recombinant protein that is a hybrid of MGFP-5 and foot protein type 1 (FP-1), where an adhesive protein with adhesive activity can be economically mass-produced to be used in place of chemical adhesives through the present invention.

Abstract: The present application describes peptides that stimulate arachidonic acid release in target cells. The application also discloses peptides that cause intracellular calcium release. The application also discloses methods of using the disclosed peptides.

Abstract: Porous members can be positioned so as to partially or fully span channels in microfluidic systems. The porous members can be assembled and/or disassembled in situ. The porous members can be made such that pores are separated by connections including but a single molecule at one location, allowing for a high level of open area in a very small pore size member. The porous member can be made up of colloid particles interconnected with molecular species. These can be used to detect analytes qualitatively and/or quantitatively, or to selectively bind and/or release agents on command for a variety of purposes including first blocking, then opening a channel, concentrating analyte over time followed by release of analyte and detection downstream, etc. Porous members can define valves in multiple-channel systems and, with controlled binding and release of agents at the porous members, these valves can be opened and closed and fluid flow controlled in a multi-channel system.

Abstract: The present application discloses a process for making ginseng wine.

Abstract: The invention involves methods, assays, and components for the detection and analysis of binding between biological or chemical species, and can specifically be used for drug discovery. In an example where drug discovery is carried out, different candidate drugs can be attached to different articles such as magnetic beads. The beads can be exposed to colloid particles carrying signaling entities, or other signaling entities, immobilized with respect to protein targets of the drug candidates. After incubation, all beads are drawn to separate surface locations magnetically. Beads are released from surface locations where it is determined that signaling entities do not exist, and are removed from the assay. Beads held at other surface locations then are released, re-distributed, and re-attracted to surface locations. This is repeated with appropriate wash steps, until individual drug candidates can be isolated and identified.

Abstract: An output circuit of a vacuum-tube amplifier is disclosed. An output circuit of a conventional vacuum-tube amplifier has shortcomings that a front end amplification unit uses a coupling condenser or a transformer to output an AC signal to an output node, a bias voltage of a cathode of a vacuum tube is varied in response to an input signal in an output buffer and, when the bias voltage is higher than a voltage set by a bias resistor, signal attenuation by the difference between the bias voltage and the set voltage is generated. To solve these shortcomings, the output circuit of the vacuum-tube amplifier includes a front end amplification unit for amplifying an input signal using a vacuum tube and an output amplification unit for power-amplifying the output signal of the front end amplification unit using a vacuum tube.

Abstract: An output circuit of a vacuum-tube amplifier is disclosed. An output circuit of a conventional vacuum-tube amplifier has shortcomings that a front end amplification unit uses a coupling condenser or a transformer to output an AC signal to an output node, a bias voltage of a cathode of a vacuum tube is varied in response to an input signal in an output buffer and, when the bias voltage is higher than a voltage set by a bias resistor, signal attenuation by the difference between the bias voltage and the set voltage is generated. To solve these shortcomings, the output circuit of the vacuum-tube amplifier includes a front end amplification unit for amplifying an input signal using a vacuum tube and an output amplification unit for power-amplifying the output signal of the front end amplification unit using a vacuum tube.

Abstract: The present invention relates to a biosensor specifically detecting a protein kinase A (PKA), and a diagnosis kit comprising the biosensor. In particular, the present invention relates to a biosensor for detecting a PKA comprising a cantilever, and a protein kinase inhibitor (PKI) immobilized on the surface of the cantilever; and a kit for diagnosing diseases caused by the increase of the activity of a protein kinase, comprising a sample, the biosensor, and a quantification manner.