Abstract: A method is provided for using a silanized silica matrix to isolate a target nucleic acids, such as plasmid DNA, fragments of DNA, chromosomal DNA, or RNA from contaminants, including proteins, lipids, cellular debris, or non-target nucleic acids. The silanized silica matrix comprises a silica based solid phase and a plurality of silane ligands covalently attached to the surface of the solid phase. Non-target material adsorbs to the silanized silica matrix in the presence of a sufficient concentration of chaotropic salt, while target nucleic acids adsorb to the matrix under other solution conditions. The method of using the silanized silica matrix of the present invention can be used to clear solutions of disrupted biological material, and to isolate nucleic acids therefrom or from other solutions containing nucleic acids and at least one contaminant.

Abstract: Disclosed is the seed of a novel soybean cultivar, designated 11508-73, a sample of which is deposited under ATCC Accession No. PTA-4188. Also disclosed are plants, or parts thereof, grown from the seed of the cultivar, plants having the morphological and physiological characteristics of the 11508-73 cultivar, and methods of using the plant or parts thereof in a soybean breeding program.

Abstract: Disclosed is the seed of a novel soybean cultivar, designated 11939, a sample of which is deposited under ATCC Accession No. PTA-4189. Also disclosed are plants, or parts thereof, grown from the seed of the cultivar, plants having the morphological and physiological characteristics of the 11939 cultivar, and methods of using the plant or parts thereof in a soybean breeding program.

Abstract: The present invention provides methods for isolating a defined quantity of DNA target material from other substances in a medium. The method may be carried out using a known quantity of a silica-containing solid support, such as silica magnetic particles, having a definable capacity for reversibly binding DNA target material, and DNA target material in excess of the binding capacity of the particles. The methods of the present invention involve forming a complex of the silica magnetic particles and the DNA target material in a mixture of the medium and particles, and separating the complex from the mixture using external magnetic force. The DNA target material may then be eluted from the complex. The quantity of DNA target material eluted may be determined based on a calibration model. The methods of the present invention permit isolation of DNA target material which is within a known quantity range.

Abstract: Disclosed are alkyl peptide amides capable of inhibiting or reducing sperm cell motility. Methods of inhibiting or reducing sperm motility using certain alkyl peptide amides are also disclosed.

Abstract: The present invention provides a method for preparing a novel class of vitamin D compounds in which the C-25 or equivalent position has a double bond. In addition, the side chain is optionally extended by one or two methylene or methyne groups. The compounds prepared by the method of the present invention are of value as prodrugs for active 1&agr;, 24-dihydroxylated vitamin D compounds.

Abstract: The present invention provides a novel formulation of nystatin for parenteral administration to treat systemic fungal infections. The formulation avoids the toxicity and solubility problems of prior art nystatin formulations.

Abstract: Disclosed is a SHAM-sensitive terminal oxidase (STO) gene from the xylose-fermenting yeast Pichia stipitis. Also disclosed is a mutant of Pichia stipitis in which the STO gene natively present in the wild-type yeast was disrupted. Mutants of Pichia stipitis having reduced expression of PsSTO were found to exhibit enhanced fermentation of xylose to ethanol.

Abstract: Disclosed is a method of reducing intraocular pressure or retinal ganglion cell death caused by specific reactive oxygen species by delivering carvedilol or a derivative or metabolite thereof having beta-adrenergic antagonist activity or specific reactive oxygen species scavenging activity to the retinal ganglion cells of a subject having or at risk of developing glaucomatous or other optic neuropathy.