Abstract: A cytotoxicity test method is provided which measures the effect of test substances or physical stimulation on cells. The method is both simple and sensitive and is useful for a wide variety of substances and stimulations.

Abstract: The disclosure herein describes a bovine embryo culture medium which includes epithelial cells from the oviduct of a donor animal. Additionally, a process for maturing immature bovine oocytes in an in vitro bovine culture medium containing epithelial cells from a donor oviduct is described. As an alternative to co-culture of the embryos with the epithelial cells, it is described how a culture medium can be conditioned for the culture of bovine embryos by the culture of epithelial cells therein which are later removed.

Abstract: Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.

Abstract: Compounds and compositions comprising fragments and methods for using synthetic analogs of thrombospondin for promoting or inhbiting thrombospondin-like activity are provided.

Abstract: Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.

Abstract: Pharmaceutical compositions and dressings useful in wound healing are provided. The pharmaceutical compositions comprise thrombospondin as the active ingredient.

Abstract: Microporous hollow fiber polysulfone membranes can be prepared continuously by using a particular combination of casting solution and precipitation solution formulations, and casting conditions. The concentration of components in the precipitation solution are adjusted continuously to maintain original concentrations. The membranes are characterized by high quality, consistent performance and uniform porosity throughout the membrane.

Abstract: Compositions and methods of use are provided for debriding and wound healing applications. The compositions contain certain proteases produced by microorganisms of the genus Vibrio.

Abstract: A novel mutant strain of Morel mushroom has been found to produce the blue pigment indigo by submerged nutrient culture medium containing a carbon and a fermentation in a nitrogen substrate. A red/purple pigment is also produced. The novel strain is Morchella rotunda nov. ES-1 sp. ATCC 20951.

Abstract: This nutrient medium is very effective for the serum-free or serum-protein-free culture of various animal cells, in both high and low density culture. Serum proteins have been replaced with non-protein-based cell growth enhancers and a non-serum derived protein supplement. The non-protein growth enhancer is a modified or derivatized polyurethane prepolymer of polymer and preferably is a sulfhydryl derivative of polyurethane. The protein supplement may be insulin, an insulin analog or an insulin-like growth factor.

Abstract: Neutral protease genes from Vibrio proteolyticus or Bacillus can be cloned and expressed in gram-negative microorganisms, such as E. coli or Serratia. The functional neutral protease enzyme is expressed.

Abstract: Storage stable pesticide compositions comprising neem seed extracts which contain azadirachtin as the active pesticidal ingredient wherein the compositions are characterized by their non-degrading solvent systems. In a first embodiment, the pesticide compositions contain solvent systems characterized as having greater than 50% by volume aprotic solvents and less than 15% by volume water. In a second embodiment, the pesticide compositions contain solvent systems characterized as having greater than 50% by volume alcohol and less than 5% by volume water. The pesticide compositions contain surfactant concentrations of at least about 1.0%, up to 10%.

Abstract: Microporous polysulfone membranes can be prepared by using a particular combination of casting solution and precipitation solution formulations, and casting conditions. The casting solution comprises polysulfone and a protein non-adsorptive prepolymer and the precipitation solution comprises a polymerization catalyst. Both hollow fiber and flat membranes can be prepared in this manner. The membranes are substantially protein non-adsorptive and have valuable physical characteristics including increased strength and high flux.

Abstract: Biocompatible polymers derived from isocyanate-capped high molecular weight triols and higher polyols are covalently linked to drugs. These polymer-modified drugs have one or more of the following advantages over the unmodified drug: reduction of immunogenicity of the drug, increased circulating half-life of the drug due to longer residence time in circulation, ability to administer multiple drugs together, and enhanced potency of the drug.

Abstract: A novel mutant strain of Morel mushroom has been found to produce the blue pigment indigo by submerged fermentation in a nutrient culture medium containing a carbon and a nitrogen substrate. A red/purple pigment is also produced. The novel strain is Morchella rotunda nov. ES-1 sp. ATCC 20951.

Abstract: Adsorbents comprising amorphous silicas with effective average pore diameters of about 20 to about 5000 Angstroms are useful in processes for the removal of trace contaminants, specifically phospholipids and associated metal ions, and chlorophyll A, from wax ester, e.g., jojoba oil.

Abstract: The drug carrier of this invention provides a temperature-sensitive polymer chemically bonded to a drug. The drug carrier is capable of releasing a drug continuously in the body. The drug carrier is a liquid when administered and becomes solid in the body, in which state it is capable of releasing a drug continuously. The drug carrier has a lower LCST than human body temperature.

Abstract: Aluminum phosphate compositions are provided which are characterized simultaneously by high porosity and phosphorous-to-aluminum ratios of approximately 1.0. The high porosity of these compositions is a function of high pore volume coupled with low surface area, resulting in high average pore diameter. These materials have excellent properties as catalysts and catalyst supports.

Abstract: Disclosed herein is an enzymatic process to bind two amino acids in the presence of a water-miscible solvent. Preferably the amino acids are precursors of aspartame and a preferred solvent is acetonitrile.

Abstract: Storage stable pesticide compositions comprising neem seed extracts which contain azadirachtin as the active pesticidal ingredient wherein the compositions are characterized by their non-degrading solvent systems. In a first embodiment, the pesticide compositions contain solvent systems characterized as having greater than 50% by volume aprotic solvents and less than 15% by volume water. In a second embodiment, the pesticide compositions contain solvent systems characterized as having greater than 50% by volume alcohol and less than 5% by volume water.