Patents Represented by Attorney JoAnn Villamizar
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Patent number: 5359135Abstract: The present invention relates to monoclonal antibodies that are distinguished by a high degree of selectivity and affinity towards triasulfurone and that are therefore outstandingly suitable for use in an immunoassay for the rapid and effective detection of triasulfurone. The present invention relates also to hybridoma cell lines that produce the said monoclonal antibodies and to immunological methods for the detection of triasulfurone in soil, water or air samples using the said monoclonal antibodies and to test kits that may be used in those detection methods.Type: GrantFiled: November 29, 1993Date of Patent: October 25, 1994Assignee: Ciba-Geigy CorporationInventors: Jean-Marc Schlaeppi, Klaus Ramsteiner, Willy Meyer
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Patent number: 5352831Abstract: Oligomeric cyanoguanidines of formula I ##STR1## wherein, for example, R.sup.1 and R.sup.2 are each phenyl, R is 1,4-phenylene and n is an integer from 1 to 20, are suitable latent hardeners for epoxy resins. They are readily soluble in solvents suitable for the application of epoxy resins, and the cured products obtained therewith have a high glass transition temperature.Type: GrantFiled: July 14, 1992Date of Patent: October 4, 1994Assignee: Ciba-Geigy CorporationInventors: Peter Flury, Martin Roth, Sameer H. Eldin
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Patent number: 5350687Abstract: The invention concerns polypeptides related to human macrophage migration inhibition factor, in particular the polypeptides called MRP-8 and MRP-14, processes for their preparation, mRNAs, DNAs and hybrid vectors coding for said polypeptides, hosts transformed with such a hybrid vector, monoclonal and polyclonal antibodies to said polypeptides , and diagnostic methods for inflammatory conditions and cystic fibrosis.Type: GrantFiled: November 21, 1990Date of Patent: September 27, 1994Assignee: Ciba-Geigy CorporationInventors: Karel G. Odink, Roger Clerc, Nico Cerletti, Josef Bruggen, Lajos Tarcsay, Clemens Sorg, Walter Wiesendanger
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Patent number: 5342955Abstract: 1,4-Diketopyrrolo[3,4-c]pyrroles of formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently of one another hydrogen, Cl, Br, CH.sub.3, OCH.sub.3, CN or phenyl, and at least one of the substituents R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is a group--O(CH.sub.2).sub.n X or --O(CH.sub.2 CH.sub.2 O).sub.p CH.sub.2 CH.sub.2 Xwhereinn is an integer from 2 to 12, andp is an integer from 1 to 3,X is a heterocyclic radical selected form the group consisting imidazolyl, pyrazolyl, triazolyl, piperazinyl, pyridinyl, pyrrolyl, thiazolyl, oxazolyl, benzoxazolyl, indolyl, benzthiazolyl, benzimidazolyl, benzotriazolyl, morpholinyl, piperidinyl and pyrrolidinyl, which radical is unsubstituted or substituted by one or two methyl groups, or is a group --NR.sub.5 R.sub.6 or --N[(CH.sub.2).sub.n -NR.sub.5 R.sub.6 ].sub.2, whereinR.sub.5 and R.sub.6 are each independently of the other hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.5 -C.sub.6 cycloalkyl.Type: GrantFiled: December 16, 1992Date of Patent: August 30, 1994Assignee: Ciba-Geigy CorporationInventors: Gary Wooden, Guy de Weck, Olof Wallquist
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Patent number: 5331068Abstract: The present invention relates to a hardener for polyfunctional epoxy resins comprising the adduct obtained from the reaction of (1) a diaminodiphenyl sulfone of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently hydrogen, C.sub.1 -C.sub.4 alkyl or halogen and (2) a cycloaliphatic diepoxide at a ratio of aminohydrogen equivalent of said sulfone to said epoxy equivalent of said diepoxide from 2.5:1 to 75:1.Type: GrantFiled: August 19, 1993Date of Patent: July 19, 1994Assignee: Ciba-Geigy CorporationInventor: Yefim Blyakhman
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Patent number: 5321103Abstract: Free-flowing powdery compositions comprisingA) liquid or semi-solid etherified aminoplast resins andB) solid colloidal condensation polymers of urea or melamine and formaldehyde having a pore volume greater than 1 cm.sup.3 /g and a specific surface area greater than 5 m.sup.2 /g.These compositions can be used, for example, as powder coating compositions.Type: GrantFiled: October 4, 1993Date of Patent: June 14, 1994Assignee: Ciba-Geigy CorporationInventor: Alfred Renner
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Patent number: 5314120Abstract: In a device for applying plant-protecting compositions and the like, having a tank for carrier fluid, for example water, and a feed pump that pumps carrier fluid from this tank through a pipe to which spray nozzles are connected, and having a metering pump that is connected by a connecting pipe to a preparation container and is driven by the carrier fluid supplied by the feed pump, in order to avoid a complicated apparatus for controlling the concentration of the preparation in the carrier fluid and to achieve reliable and accurate metering, the metering pump (5) is connected in series with the feed pump (2) so that the whole of the carrier fluid flowing through the pipe (3) passes through the metering pump (5), wherein the carrier fluid drives a drive element (12) in the metering pump (5), which in turn drives a metering mechanism (13, 14) which is connected to the connecting pipe (10) leading to the preparation container (11) and is provided with a setting sleeve (15) for the concentration of the preparatioType: GrantFiled: June 18, 1993Date of Patent: May 24, 1994Assignee: Ciba-Geigy CorporationInventors: Karl L. Nau, Hans Raffel, Heinrich David
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Patent number: 5310943Abstract: Aromatic trisanhydrides of the formula (I) ##STR1## wherein R is hydrogen, C.sub.1 -C.sub.4 alkyl or aryl are useful for the synthesis of star-branched and star-burst polyester-imides and polyesterimide-amides and as curing agents for epoxy resins, phenolics and polyesters.Type: GrantFiled: April 23, 1993Date of Patent: May 10, 1994Assignee: Ciba-Geigy CorporationInventor: Yefim Blyakhman
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Patent number: 5298609Abstract: Compounds of formula I ##STR1## wherein R is a radical of formula --OR.sub.3 or --NHR.sub.3, A is a radical of formula II or III ##STR2## and B is a radical of formula ##STR3## wherein n is 1 or 2,R.sub.1 is --H or --Cl,R.sub.2 is --H, halogen, --NO.sub.2, --CN, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, --CF.sub.3, C.sub.2 -C.sub.5 alkoxycarbonyl, --CONH--phenyl, --NHCO-phenyl or phenoxy, each unsubstituted or substituted in the phenyl nucleus by one or two chlorine atoms or by one or two methyl, methoxy or ethoxy groups,R.sub.3 is C.sub.5 -C.sub.12 cycloalkyl, which is unsubstituted or substituted by 1 to 3 C.sub.1 -C.sub.4 alkyl or C.sub.5 -C.sub.6 cycloalkyl groups,R.sub.4 and R.sub.5 are each independently of the other --H, halogen, --NO.sub.2, --CN, --CF.sub.3, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy,R.sub.6 is --H, --Cl, --Br, --CH.sub.3 or --OCH.sub.3, andX is --H, --Br, --OCH.sub.3, --CN or --NO.sub.2,are suitable for use as pigments, especially for colouring polyolefins.Type: GrantFiled: July 14, 1993Date of Patent: March 29, 1994Assignee: Ciba-Geigy CorporationInventor: Stefan Hari
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Patent number: 5282897Abstract: A process for improving the storage stability of a colored organic pigment in powder form which comprises coating pigment particles with a partially or completely hydrolysed compound of an element of Group IVA or Group IVB of the Periodic Table in its IV oxidation state, thereby inhibiting reduction of the tinting strength of the pigment on storage.Type: GrantFiled: August 11, 1992Date of Patent: February 1, 1994Assignee: Ciba-Geigy CorporationInventors: Phillipe Bugnon, Abul Iqbal, Iain F. Fraser, Wern T. Tsai
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Patent number: 5280121Abstract: Compounds of formula ##STR1## wherein R is C.sub.7 -C.sub.21 alkyl, C.sub.4 -C.sub.18 alkenyl, C.sub.5 -C.sub.12 cycloalkyl or C.sub.5 -C.sub.6 cycloalkyl-substituted C.sub.1 -C.sub.4 alkyl,R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently of one another hydrogen, chloro, bromo, methyl or methoxy,Z is a direct bond or --O--, --S--, --NH--, --CO--, --SO.sub.2 -- or --NHCO--, andn is 0 or 1.These compounds have excellent suitability as pigments for coloring organic material of high molecular weight, especially polyvinyl chloride, polyolefins and paints.Type: GrantFiled: June 30, 1992Date of Patent: January 18, 1994Assignee: Ciba-Geigy CorporationInventor: Stefan Hari
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Patent number: 5280069Abstract: The new compound N,N,N'N'-tetraglycidyl-3,3'-diethyl-4,4'-diaminodiphenylmethane and curable resin compositions containing it.Type: GrantFiled: April 30, 1991Date of Patent: January 18, 1994Assignee: Ciba-Geigy CorporationInventors: Bryan Dobinson, Michael R. Thoseby
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Patent number: 5278257Abstract: Compositions containing A) a copolymer based on at least one 1,3-diene and at least one polar, ethylenically unsaturated comonomer and B) a phenol-terminated polyurethane, polyurea or polyurea-urethane of the formula I ##STR1## in which m is 1 or 2, n is 2 to 6, R.sup.1 is the n-valent radical of an elastomeric prepolymer which is soluble or dispersible in epoxide resins, X and Y independently of one another are --O-- or --NR.sup.3 --, it being necessary for one of these groups to be --NR.sup.3 --, R.sup.2 is an m+1-valent radical of a polyphenol or aminophenol after the removal of the phenolic hydroxy group(s) or the amino group or both the amino group and the phenolic hydroxyl group, respectively, and R.sup.3 is hydrogen, C.sub.1 -C.sub.6 alkyl or phenyl, are described.Compounds containing the components A) and B) as well as an epoxide resin C) are also described.The cured products are distinguished by a high peel strength and high resistance to crack propagation.Type: GrantFiled: January 21, 1992Date of Patent: January 11, 1994Assignee: Ciba-Geigy CorporationInventors: Rolf Mulhaupt, Jeremy H. Powell, Christopher S. Adderley, Werner Rufenacht
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Patent number: 5278260Abstract: A process for the preparation of epoxy resins having a specific reproducible content of .alpha.-glycol groups, which process comprises adding at least 0.0085 mol of glycidol or glycidol precursor compound per hydroxy-equivalent of a phenolic compound A which contains 2, 3 or 4 phenolic hydroxyl groups during the reaction of said phenolic compound A with an epihalohydrin which is unsubstituted or substituted in 2- or 3-position by C.sub.1 -C.sub.4 alkyl. The products may be used for surface protection.Type: GrantFiled: October 13, 1992Date of Patent: January 11, 1994Assignee: Ciba-Geigy CorporationInventors: Werner Schaffner, Dimiter Hadjistamov
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Patent number: 5274010Abstract: A process for warp-free pigmenting of polyolefins comprising(A)(i) adsorbing a polyvinyl alcohol film onto the surface of an organic pigment particle,(ii) coating the surface of the polyvinyl alcohol coated organic pigment particle with one or more films of linear or branched homopolymers or copolymers selected from the group consisting of acrylic polymers based on acrylic acid, methacrylic acid, alkyl esters of acrylic or methacrylic acid and mixtures thereof, and(iii) admixing said pigment particles with a polyolefin; or(B)(i) adsorbing a film of hydrolysed zirconium acetylacetonate onto the surface of an organic ##STR1## in which R is methyl or ethyl and m is a number from 1 to 6, onto the surface of the hydrolysed zirconium acetylacetonate coated organic pigment particle, (ii) coating the surface of organic pigment particle coated in accordance with step (B)(i) with one or more films of linear or branched homopolymers or copolymers selected from the group consisting of acrylic polymers based on acrylic acType: GrantFiled: July 5, 1991Date of Patent: December 28, 1993Assignee: Ciba-Geigy CorporationInventors: Philippe Bugnon, Fritz Herren
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Patent number: 5271769Abstract: A method of improving the storage stability of a coloured organic pigment in powder form which comprises coating pigment particles with a solid polymer which is a polar group-containing vinyl polymer, said polar group being a hydroxy, carboxyl, carboxylic ester, anhydride or carboxamide group, or a cellulosic polymer, thereby inhibiting reduction of tinting strength of the pigment on storage.Type: GrantFiled: August 11, 1992Date of Patent: December 21, 1993Assignee: Ciba-Geigy CorporationInventors: Philippe Bugnon, Abul Iqbal, Alison MacLennan, Iain F. Fraser
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Patent number: 5272059Abstract: The invention concerns a process for the preparation of hybridoma cells which secrete monoclonal antibodies specific for hirudin, the hybridoma cells themselves, the monoclonal antibodies specific for hirudin secreted by these hybridoma cells, derivatives thereof, and a process for the preparation of said antibodies and derivatives. These monoclonal anti-hirudin antibodies and their derivatives are useful for the determination of hirudin and as an antidote to hirudin. The invention also concerns test kits and pharmaceutical compositions comprising said monoclonal antibodies and/or derivatives.Type: GrantFiled: July 27, 1992Date of Patent: December 21, 1993Assignee: Ciba-Geigy CorporationInventors: Jean-Marc Schlaeppi, Dietmar G. Braun
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Patent number: 5271759Abstract: Pigment compositions comprisinga) at least one organic pigment,b) 0.05 to 10% by weight, based on the organic pigment a), of at least one modified organic pigment of formula ##STR1## wherein A is the radical of an organic pigment, X is H, Na or K and m is an integer from 0.05 to 3, andc) 0.05 to 10% by weight, based on the organic pigment a), of at least one polymeric ammonium salt having an average molecular weight from 500 to 2 500 000 and which is soluble in water or a lower alkanol.These pigment compositions have excellent suitability for the wrap-free pigmenting of polyolefins and, when incorporated in paint systems and printing inks, exhibit excellent rheology.Type: GrantFiled: May 1, 1992Date of Patent: December 21, 1993Assignee: Ciba-Geigy CorporationInventors: Gary Wooden, Olof Wallquist
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Patent number: 5262072Abstract: A composition comprisinga) a lubricant or a hydraulic fluid, andb) at least one compound of general formula I ##STR1## wherein x is 1 or 2 and, when x is 1, n is 2 and R has the meaning of R.sub.1, or, when x is 2, n is 1 and R has the meaning of R.sub.4, R.sub.1 is alkyl of 1 to 25 carbon atoms, an unsubstituted or C.sub.1 -C.sub.8 -alkyl-substituted cycloalkyl group of 5 to 12 carbon atoms, alkenyl of 2 to 18 carbon atoms, phenyl, naphthyl, C.sub.7 -C.sub.18 phenylalkyl, C.sub.7 -C.sub.18 alkylphenyl or --NR.sub.5 R.sub.6, and R.sub.2 and R.sub.3 are identical or different and are alkyl of 1-18 carbon atoms, phenyl, naphthyl, C.sub.7 -C.sub.18 phenylalkyl or C.sub.7 -C.sub.18 alkylphenyl, or R.sub.2 and R.sub.3, together with the linking nitrogen atom, form a 5- to 7-membered heterocyclic ring which may additionally contain a N- or O-atom, R.sub.Type: GrantFiled: June 24, 1991Date of Patent: November 16, 1993Assignee: Ciba-Geigy CorporationInventors: Hugo Camenzind, Rolf Schumacher
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Patent number: 5256323Abstract: Compositions comprisinga) a functional liquid or an internal combustion engine fuel andb) at least one compound of the general formula I ##STR1## wherein R.sub.1 is --(CH.sub.2 --X).sub.n --R, where X=--S-- or --O--, n=0 or 1 and R is an alkyl group of 1 to 18 carbon atoms, a phenyl group, a phenyl group which is substituted by at least one C.sub.1 -C.sub.18 alkyl group, a phenyl-C.sub.1 -C.sub.4 alkyl group or a phenyl-C.sub.1 -C.sub.4 alkyl group which is substituted by at least one C.sub.1 -C.sub.4 alkyl group, or R.sub.1 is an alkyl group of 1 to 18 carbon atoms which is substituted by at least one OH group, or R.sub.1 is a ##STR2## group in which the alkyl moiety contains 1 to 18 carbon atoms, and R.sub.2 and R.sub.3 are the same or different and are --H or, independently of R.sub.1, have the same meanings as R.sub.1, and M is B, Al, Fe, Cr, Sb or Bi, or M is a group M'--R' or a group M'--OR", where M' is Ti, Zr or Sn, and R' and R" is C.sub.1 -C.sub.Type: GrantFiled: January 7, 1991Date of Patent: October 26, 1993Assignee: Ciba-Geigy CorporationInventors: Hermann O. Wirth, Hans-Helmut Friedrich