Patents Represented by Attorney, Agent or Law Firm John D. Upham
  • Patent number: 4059486
    Abstract: SV3T3 cells are rapidly propagated in vitro to elaborate MIF and TAF by first growing on a surface and thereafter transferring an inoculum of the growing cells into an agitated liquid suspension of nutrient culture medium, incubating at 30.degree.-38.degree. C while continuing the agitation of the medium, periodically transferring the growing cells into fresh medium and continuing the incubation with agitation of the medium, whereby said cells are proliferated in aggregates and elaborate MIF and TAF in significantly detectable amounts.
    Type: Grant
    Filed: November 3, 1976
    Date of Patent: November 22, 1977
    Assignee: Monsanto Company
    Inventor: William R. Tolbert
  • Patent number: 4058548
    Abstract: A process is described for converting methyl amines to acetonitrile by heating with a transition metal catalyst in the presence of hydrogen.
    Type: Grant
    Filed: June 3, 1976
    Date of Patent: November 15, 1977
    Assignee: Monsanto Company
    Inventors: Gisela Olive, Salvador Olive
  • Patent number: 4052461
    Abstract: The invention relates to a process for the preparation of aldehydes by the hydroformylation of olefinically unsaturated compounds using a rhodium catalyst which catalyst is provided by (1) introducing rhodium into the reaction solution in the form of an ionic rhodium compound, the said ionic compound consisting of (a) a rhodium-containing cation having rhodium complexed with ligands other than halide, and (b) a non-coordinating anion; and (2) furnishing to the reaction solution at least two moles of a modifying ligand per mole of ionic rhodium compound where the modifying ligand is furnished either pre-coordinated in the said ionic rhodium compound or as a free compound, and where the modifying ligand is a tertiary organo phosphorous compound having from 3 to 90 carbon atoms, or a tertiary organo arsenic compound having from 3 to 90 carbon atoms, or a tertiary organo antimony compound having from 3 to 90 carbon atoms.
    Type: Grant
    Filed: April 4, 1975
    Date of Patent: October 4, 1977
    Assignee: Monsanto Company
    Inventors: Harold Burnham Tinker, Donald E. Morris
  • Patent number: 4051070
    Abstract: Provisions are taken to counter nitrogen oxide fumes produced in catalyst preparation involving metal nitrate decomposition, as by including urea or another scavenger, or by delaying calcining until used as catalyst in treating auto exhaust.
    Type: Grant
    Filed: January 2, 1974
    Date of Patent: September 27, 1977
    Assignee: Monsanto Company
    Inventors: Wesley B. Argo, James W. Edwards, Albert P. Little, William M. Lumb
  • Patent number: 4045297
    Abstract: A method of determining triglycerides in biological fluids which comprises reacting a biological fluid sample with a lipolytic enzyme to liberate free glycerol, reacting said free glycerol with a coupled enzyme series in an oxygenated aqueous solution containing ATP, GK, .alpha.-GPDH, NAD and an electron transfer agent, and measuring the uptake of oxygen by the oxidation of the resulting NADH with an oxygen-sensing electrode.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: August 30, 1977
    Assignee: Monsanto Company
    Inventors: Lloyd E. Weeks, John H. Johnson, Margaret J. Reents
  • Patent number: 4042462
    Abstract: A method of determining creatine phosphokinase activity in biological fluids comprising reacting a biological fluid sample with a coupled enzyme series in an oxygenated aqueous solution containing creatine phosphate, ADP, glucose, HK, G-6-PDH, NADP and an electron transfer agent and measuring the uptake of oxygen by the oxidation of the resulting NADPH with an oxygen-sensing electrode.
    Type: Grant
    Filed: December 24, 1975
    Date of Patent: August 16, 1977
    Assignee: Monsanto Company
    Inventors: John H. Johnson, Lloyd E. Weeks
  • Patent number: 4035428
    Abstract: A process for production of orthophenylphenol is disclosed. More specifically, the invention relates to the conversion of phenol or diphenyl ether into orthophenylphenol in a two-stage process in which dibenzofuran is an intermediate.
    Type: Grant
    Filed: August 8, 1975
    Date of Patent: July 12, 1977
    Assignee: Monsanto Company
    Inventors: Norman A. Fishel, David E. Gross
  • Patent number: 4032406
    Abstract: A method of determining dopamine-.beta.-hydroxylase (D.beta.H) activity in biological fluids which comprises reacting a D.beta.H-specific substrate with a sample of said biological fluid in the presence of ascorbate, fumarate and oxygen and measuring the uptake of oxygen by the resulting hydroxylation with an oxygen-sensing electrode.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: June 28, 1977
    Assignee: Monsanto Company
    Inventor: Lloyd E. Weeks
  • Patent number: 4029748
    Abstract: The complexes [Ir(CO).sub.3 I], [HIr(CO).sub.3 I.sub.2 ], [HIr(CO).sub.2 I.sub.2 (H.sub.2 O)], [RIr(CO).sub.2 I.sub.2 ], [(RCO)Ir(CO).sub.2 I.sub.2 ] where R is an alkyl radical, are described. Processes for preparing the aforesaid complexes are described and in addition a new process for preparation of [Ir(CO).sub.3 I.sub.3 ] is described.
    Type: Grant
    Filed: July 29, 1974
    Date of Patent: June 14, 1977
    Assignee: Monsanto Company
    Inventors: Denis Forster, Arnold Hershman, Donald E. Morris
  • Patent number: 4028201
    Abstract: Olefinic nitriles, esters and amides are electrolytically mono-carboxylated in the presence of carbon dioxide and a proton donor.
    Type: Grant
    Filed: November 13, 1972
    Date of Patent: June 7, 1977
    Assignee: Monsanto Company
    Inventor: Donald Armon Tyssee
  • Patent number: 4024020
    Abstract: A method of culturing cells in which the cells are fixed on a polyacrylonitrile surface.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: May 17, 1977
    Assignee: Monsanto Company
    Inventors: Stefan A. Weiss, John H. Johnson
  • Patent number: 4021321
    Abstract: Elemental phosphorus is oxidized via indirect electrolytic oxidation in an electrolysis medium containing elemental phosphorus, an aqueous solution of hydrogen halide, and a non-aqueous solvent to produce phosphorous acid, (HO).sub.2 HPO.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: May 3, 1977
    Assignee: Monsanto Company
    Inventor: Donald A. White
  • Patent number: 4021322
    Abstract: Elemental phosphorus is oxidized via indirect electrolytic oxidation to yield phosphorous acid, (HO).sub.2 HPO.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: May 3, 1977
    Assignee: Monsanto Company
    Inventor: Michael J. Dolan
  • Patent number: 4017597
    Abstract: A unitized solid phase kit for radioimmunoassay is disclosed. All of the necessary assay reagents are incorporated in a single tube wherein all phases of the assay procedure are performed, requiring only the addition of the patient's sample. Antibody is bound to the tube surface, while labelled antigen is also present but unbound. Storage in the absence of air and water results in the stabilization of the reagents such that the system can be stored for long periods.
    Type: Grant
    Filed: October 30, 1974
    Date of Patent: April 12, 1977
    Assignee: Monsanto Company
    Inventor: John H. Reynolds
  • Patent number: 4013514
    Abstract: Water-insoluble, biologically active conjugates for use in a reactor core of a flow-through reactor are prepared by covalently bonding an enzyme directly to a fibrous dialdehyde cellulose such as cotton. Preferably the fibrous cellulose is placed in the reactor core of a flow-through reactor before or after it is treated with periodic acid solution to convert glucose units thereof to units containing dialdehyde groups. Thereafter, an enzyme solution is passed through the resultant dialdehyde cellulose to bind the enzyme to the cellulose.
    Type: Grant
    Filed: January 2, 1974
    Date of Patent: March 22, 1977
    Assignee: Monsanto Company
    Inventors: Bernard S. Wildi, Lloyd E. Weeks
  • Patent number: 4013524
    Abstract: .alpha.,.beta.-Olefinic nitriles, esters and amides are electrolytically carboxylated and dimerized.
    Type: Grant
    Filed: December 21, 1972
    Date of Patent: March 22, 1977
    Assignee: Monsanto Company
    Inventor: Donald Armon Tyssee
  • Patent number: 4013694
    Abstract: A method for preparation of heterocyclic fused ring compounds by dehydration and dehydrogenation of certain phenolic compounds in the presence of a cerium oxide catalyst is disclosed. Preferred phenolic compounds, catalytic materials, and reaction conditions also are described.
    Type: Grant
    Filed: August 8, 1975
    Date of Patent: March 22, 1977
    Assignee: Monsanto Company
    Inventor: Norman A. Fishel
  • Patent number: 4011299
    Abstract: Process for removing sulfur dioxide and nitrogen oxides from gaseous mixtures which comprises contacting such mixtures, in the presence of a reducing agent comprising carbon monoxide, hydrogen, or mixtures thereof, with a solid reagent comprising calcium oxide, magnesium oxide, or mixtures thereof at temperatures in excess of about 700.degree. C.
    Type: Grant
    Filed: October 1, 1975
    Date of Patent: March 8, 1977
    Assignee: Monsanto Company
    Inventors: Jay M. Henis, Mary K. Tripodi
  • Patent number: 4009185
    Abstract: A method for preparation of heterocyclic fused ring compounds by dehydrogenation of certain aromatic ether compounds in the presence of a cerium oxide catalyst is disclosed. Preferred aromatic ether compounds, catalytic materials, and reaction conditions also are described.
    Type: Grant
    Filed: August 8, 1975
    Date of Patent: February 22, 1977
    Assignee: Monsanto Company
    Inventor: Norman A. Fishel
  • Patent number: 4008254
    Abstract: A method for preparation of heterocyclic fused ring compounds by dehydration and dehydrogenation of certain phenolic compounds in the presence of water vapor and in the presence of a cerium oxide catalyst is disclosed. Preferred phenolic compounds, catalytic materials, and reaction conditions also are described.
    Type: Grant
    Filed: August 8, 1975
    Date of Patent: February 15, 1977
    Assignee: Monsanto Company
    Inventors: David E. Gross, Norman A. Fishel