Abstract: A casting mold is provided for forming a biomedical device including an ophthalmic device such as a contact lens. The casting mold includes an anterior mold section and a posterior mold section, wherein one of the mold sections includes a plurality of radially extending ribs and the remaining mold section includes an annular shoulder for engaging an outer end of the ribs to define a mold cavity.

Abstract: A method is provided of forming a biomedical device in a casting mold which has an anterior mold section and a posterior mold section, wherein one of the mold sections includes a plurality of radially extending ribs and the remaining mold section includes an annular shoulder for engaging an outer end of the ribs to define a mold cavity. The method includes engaging the mold sections along a peripheral seal of the mold cavity and a plurality of circumferentially spaced contact points on a shoulder of one of the mold sections. Cured excess material bonds to the ribs of the one mold section and provides repeatable retention and location of the excess material after formation of the biomedical device.

Abstract: At least one of the surfaces of a silicone contact lens is a wrinkled surface, providing the contact lens surface with a desired topography. The wrinkled surface may include random ridges, either over the entire surface of the lens, or in a desired pattern on the surface of the lens.

Abstract: A method of quantitatively analyzing a sample analyte involves performing matrix-assisted laser desorption ionization mass spectrometry on the sample analyte and an internal standard, and comparing the mass spectrometry of the sample analyte with the mass spectrometry of the internal standard.