Abstract: A pharmaceutical composition is provided comprising a vehicle that comprises (a) an amphipathic oil that is water dispersible and ethanol insoluble, (b) microcrystalline wax, and (c) a pharmaceutically acceptable non-aqueous carrier; and having an antibacterial substance in an antibacterially effective amount stably dispersed in the vehicle. The composition is suitable for administration by intramammary infusion to a milk producing animal for treatment and/or prevention of mastitis or other diseases of the udder, as well as for otic administration for treatment and/or prevention of an ear infection.
Type:
Grant
Filed:
October 17, 2003
Date of Patent:
November 30, 2010
Inventors:
Nancy Jean Britten, Niki Ann Waldron, John W. Burns
Abstract: A composition comprising: (a) one to three bioactive agents; and (b) a modified liquid vehicle; wherein immediately after manufacture of the composition, said composition can be administered to a host such that the one to three bioactive agents is released to the host on a sustained basis is provided.
Type:
Grant
Filed:
November 10, 2003
Date of Patent:
November 9, 2010
Inventors:
Dirk L. Teagarden, Nancy J. Britten, Scott A. Brown, James F. Caputo, Leslie C. Eaton, Ondrej Hendl, Syed F. Huda, Harry M. King, Susan M. Machkovech, Randal Lee Schapaugh, Stanley M. Speaker, Jean M. Steele, Ching-Chiang Su, Terry R. Urban, Niki A. Waldron, Monica L. Whitmire
Abstract: A composition comprising: (a) one to three bioactive agents; and (b) a vehicle comprising; (i) a modified liquid carrier, and (ii) an unmodified liquid carrier wherein the ratio by volume of the modified liquid carrier to the unmodified liquid carrier is between 0.00001:99.99999 to less than 0.01:99.99, that provide the composition with predictable sustained-release properties and wherein immediately after manufacture of the composition, said composition can be administered to a host such that the one to three bioactive agents is released to the host on a sustained basis.
Type:
Grant
Filed:
November 12, 2003
Date of Patent:
February 9, 2010
Assignee:
Pharmacia & Upjohn Company
Inventors:
Ondrej Hendl, Susan Marie Machkovech, Niki Ann Waldron, Nancy Jean Britten, Dannette M. Shaw, Alanta Lea Lary, Thomas J. Yellig
Abstract: Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)- signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.
Abstract: The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
Type:
Grant
Filed:
December 24, 2003
Date of Patent:
December 4, 2007
Assignee:
Esperion Therapeutics, Inc.
Inventors:
Jean-Louis Dasseux, Daniela Carmen Oniciu
Abstract: The present invention relates to a process for preparing 2-(pyridin-4-ylamino-pyrido [2,3-d]pyrimidine of Formula II by reacting a 4-aminopyridine of the formula with a 2-(4-imino-4H-pyridin-1-yl)-pyrido[2,3-d]pyrimidine of Formula I in the presence of a base. It also relates to an alternative process for preparing a compound of Formula II by reacting the aminopyridine hereinabove with in a unreactive organic solvent. It also relates to the compound of Formula III.
Type:
Grant
Filed:
July 12, 2001
Date of Patent:
November 1, 2005
Assignee:
Warner-Lambert Company
Inventors:
Vladimir Genukh Beylin, Richard Jungkyu Lee, Mark Eugene Marlatt
Abstract: The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of Formulea I and II, described herein, or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
Type:
Grant
Filed:
October 2, 2003
Date of Patent:
April 5, 2005
Assignee:
Pharmacia & Upjohn Company
Inventors:
Mikhail Fedor Gordeev, Adam Renslo, Dinesh Vinoobhai Patel
Abstract: The present invention relates to (2S)-enantiomers of 2-aminoindan derivatives of formula I: and a novel process for the preparation of them.
Type:
Grant
Filed:
April 29, 2002
Date of Patent:
March 22, 2005
Assignee:
Pharmacia & Upjohn Company
Inventors:
Arthur Glenn Romero, Thomas Andrew Runge, Bradley D. Hewitt, Kjell Anders Ivan Svensson, Chiu-Hong Lin, Kerry Anne Cleek, Susanne R. Haadsma-Svensson
Abstract: The present invention is a novel process for the transformation of 17&agr;-hydroxy-6&agr;-methylpregn-4-ene-3,20-dione 17-acetate (I)
to 11&bgr;,17&agr;,21-trihydroxy-6&agr;-methylpregna-1,4-diene-3,20-dione 21-acetate (VI)
Type:
Grant
Filed:
June 14, 2002
Date of Patent:
December 7, 2004
Assignee:
Pharmacia and Upjohn Company
Inventors:
Bruce Allen Pearlman, Michael J. White, Ivan G. Gilbert
Abstract: The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA)
X2—CH2—C*H(OH)—CH2—NH—CO—RN (VIIIA)
and processes for production of pharmacologically useful oxazolidinones.
Abstract: The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA)
X2—CH2—C•H(OH)—CH2—NH—CO—RN (VIIIA)
and processes for production of pharmacologically useful oxazolidinones.
Abstract: The present invention is a novel intermediate, compound of the formula (VI)
and salts thereof. In addition, the invention includes a process for the preparation of a 15(S)-prostaglandin intermediates compounds (IV) and (XVIII) which comprises (1) contacting a the corresponding enone with (−)-chlorodiisopinocampheylborane while maintaining the reaction mixture temperature in the range of from about −50° to about 0° and (2) contacting the reaction mixture of step (1) with a boron complexing agent.
Abstract: The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA)
X2—CH2—C*H(OH)—CH2—NH—CO—RN (VIIIA)
and processes for production of pharmacologically useful oxazolidinones.
Abstract: The present invention is a process for the conversion of bisnoralcohol to bisnoraldehyde (II), which is a known intermediate in the synthesis of progesterone.
Abstract: The present invention is an improved prosess to prepare (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one the compound of formula (VII)
Abstract: The present invention is a process, including intermediates, to produce (2S)-2-dipropylamino)-6-ethoxy-2,3-dihydro-1H-indene-5-carboxamide
which is a useful pharmaceutical agent.
Type:
Grant
Filed:
June 6, 2002
Date of Patent:
June 10, 2003
Assignee:
Pharmacia & Upjohn Company
Inventors:
Jiong Jack Chen, Arthur Glenn Romero, Styrbjorn Bystrom
Abstract: The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA)
X2—CH2—C*H(OH)—CH2—NH—CO—RN (VIIIA)
and processes for production of pharmacologically useful oxazolidinones.