Patents Represented by Attorney John Harbour
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Patent number: 7915420Abstract: The invention provides novel GlyT2 inhibiting compounds useful in modulating, treating, or preventing: anxiolytic disorders; a condition requiring treatment of injured mammalian nerve tissue; a condition amenable to treatment through administration of a neurotrophic factor; a neurological disorder; or obesity; an obesity-related disorder.Type: GrantFiled: July 19, 2007Date of Patent: March 29, 2011Assignee: Janssen Pharmaceutica NVInventors: Charles Q. Huang, Timothy W. Lovenberg, Alejandro Santillán, Jr., Liu Y. Tang, Ronald L. Wolin
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Patent number: 7576105Abstract: The present invention is directed to N-benzyl substituted (piperidin-4-yl)aminobenzamido derivatives which are delta-opioid receptor modulators.Type: GrantFiled: December 21, 2005Date of Patent: August 18, 2009Assignee: Janssen Pharmaceutica, NVInventors: Ellen W. Baxter, Allen B. Reitz
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Patent number: 7504426Abstract: Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis.Type: GrantFiled: September 4, 2003Date of Patent: March 17, 2009Assignee: Janssen Pharmaceutica N.V.Inventors: Nicholas I. Carruthers, Curt A. Dvorak, James P. Edwards, Cheryl A. Grice, Jill A. Jablonowski, Kiev S. Ly, Barbara A. Pio, Chandravadan R. Shah, Jennifer D. Venable
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Patent number: 7504414Abstract: 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.Type: GrantFiled: August 2, 2007Date of Patent: March 17, 2009Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Kristen L. Arienti, Frank U. Axe, J. Guy Breitenbucher, Liming Huang, Alice Lee, Kelly J. McClure
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Patent number: 7498343Abstract: The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or the general Formula (Ib) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. The claimed compounds are useful for the treatment of mycobacterial diseases, particularly those diseases caused by pathogenic mycobacteria such as Mycobacterium tuberculosis, M. bovis, M. avium and M. marinum. In particular, compounds are claimed in which, independently from each other, R1 is bromo, p=1, R2 is alkyloxy, R3 is optionally substituted naphthyl or phenyl, q=1, R4 and R5 each independently are hydrogen, methyl or ethyl, R6 is hydrogen, r is equal to 0 or 1 and R7 is hydrogen.Type: GrantFiled: December 8, 2004Date of Patent: March 3, 2009Assignee: Janssen Pharmaceutica N.V.Inventors: Jozef Frans Elisabetha Van Gestel, Jérôme Emile Georges Guillemont, Marc Gaston Venet, Hervé Jean Joseph Poignet, Laurence Françoise Bernadette Decrane, Daniel F. J. Vernier, Frank Christopher Odds
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Patent number: 7482364Abstract: Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.Type: GrantFiled: October 18, 2007Date of Patent: January 27, 2009Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Richard Apodaca, Xiaohu Deng, Jill A. Jablonowski, Neelakandha Mani, Chennagiri R. Pandit, Wei Xiao
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Patent number: 7456208Abstract: Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases.Type: GrantFiled: July 3, 2007Date of Patent: November 25, 2008Assignee: Janssen Pharmaceutica N.V.Inventors: J. Guy Breitenbucher, Michael D. Hack, Clark A. Sehon
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Patent number: 7446104Abstract: Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.Type: GrantFiled: October 18, 2007Date of Patent: November 4, 2008Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Richard Apodaca, Xiaohu Deng, Jill A. Jablonowski, Neelakandha Mani, Chennagiri R. Pandit, Wei Xiao
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Patent number: 7358261Abstract: This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alkylamide derivatives as bradykinin receptor agonists useful for the treatment of bradykinin modulated disorders such as hypertension and the like.Type: GrantFiled: December 16, 2004Date of Patent: April 15, 2008Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: John R. Carson, Michele C. Jetter, Jung S. Lee, Mark A. Youngman
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Patent number: 7276610Abstract: The invention provides novel GlyT2 inhibiting compounds useful in modulating, treating, or preventing: anxiolytic disorders; a condition requiring treatment of injured mammalian nerve tissue; a condition amenable to treatment through administration of a neurotrophic factor; a neurological disorder; or obesity; an obesity-related disorder.Type: GrantFiled: August 17, 2004Date of Patent: October 2, 2007Assignee: Janssen Pharaceutica, NVInventors: Charles Q. Huang, Timothy W. Lovenberg, Alejandro Santillán, Jr., Liu Y. Tang, Ronald L. Wolin
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Patent number: 7271261Abstract: 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.Type: GrantFiled: October 18, 2002Date of Patent: September 18, 2007Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Kristen L. Arienti, Frank U. Axe, J. Guy Breitenbucher, Liming Huang, Alice Lee, Kelly J. McClure
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Patent number: 7250427Abstract: Aryl substituted benzimidazole and imidazo[4,5]pyridine ethers are described as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.Type: GrantFiled: June 27, 2005Date of Patent: July 31, 2007Assignee: Janssen Pharmaceutica, N.V.Inventors: J. Guy Breitenbucher, Alice Lee-Dutra, Danielle K. Neff
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Patent number: 7250434Abstract: Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases.Type: GrantFiled: December 21, 2004Date of Patent: July 31, 2007Assignee: Janssen Pharmaceutica N.V.Inventors: J. Guy Breitenbucher, Michael D. Hack, Clark A. Sehon
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Patent number: 7241759Abstract: Certain amidophenyl-sulfanylamino-benzo[1,2,5]thiadiazole compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases.Type: GrantFiled: March 26, 2004Date of Patent: July 10, 2007Assignee: Janssen Pharmaceutica N.V.Inventors: Brett Allison, Laura C. McAtee, Victor K. Phuong, Michael H. Rabinowitz, Nigel P. Shankley
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Patent number: 7202269Abstract: Certain ?-, ?-, and ?-amino acid derivatives are disclosed as selective GlyT2 inhibitors for the treatment of central nervous system (CNS) conditions such as muscle spasticity, tinnitus, epilepsy and neuropathic pain.Type: GrantFiled: October 28, 2004Date of Patent: April 10, 2007Assignee: Janssen Pharmaceutica N.V.Inventors: Tristin K. Barclay, Alejandro Santillán, Jr., Liu Y. Tang, Hariharan Venkatesan, Ronald L. Wolin
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Patent number: 7179808Abstract: This invention is directed to substituted heteroaryl and heterocyclic compounds as nicotinamide adenine dinucleotide oxidase hydride donor inhibitors useful in treating or ameliorating a reactive oxygen species mediated inflammatory disorder.Type: GrantFiled: July 2, 2003Date of Patent: February 20, 2007Assignee: Janssen Pharmaceutica N.V.Inventor: Scott Beers
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Patent number: 7179818Abstract: This invention is directed towards substituted aminoquinuclidine compounds useful as delta-opioid receptor modulators, delta-opioid receptor agonists useful as analgesics and delta-opioid receptor antagonists useful as immunosuppressants, antiinflammatory agents, agents for the treatment of neurological and psychiatric conditions, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents and agents for the treatment of respiratory diseases.Type: GrantFiled: October 14, 2003Date of Patent: February 20, 2007Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Robert E. Boyd, Allen B. Reitz
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Patent number: 7071191Abstract: Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions.Type: GrantFiled: August 6, 2001Date of Patent: July 4, 2006Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Richard Apodaca, Nicholas I. Carruthers, Curt A. Dvorak, Chandravadan R. Shah, Wei Xiao
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Patent number: 6888001Abstract: The present invention provides compounds of the formula: wherein m is 0, 1 or 2; p is 0 or 1; Y is O, S, S(O) or S(O)2 and R1 to R7 are various substituents as selective modulators of the nicotinic acetylcholine receptor useful in the treatment of pain, Alzheimer's disease, memory loss or dementia or loss of motor function.Type: GrantFiled: April 2, 2003Date of Patent: May 3, 2005Inventor: Jung S. Lee
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Patent number: 6884803Abstract: Disclosed are substituted phenylalkynes of formula (I), wherein R1, R2, R3, R4, R5 and n are as defined, compositions containing them, and methods of making and using them to treat histamine-mediated conditions.Type: GrantFiled: December 2, 2002Date of Patent: April 26, 2005Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Richard Apodaca, Wei Xiao, Jill A. Jablonowski