Patents Represented by Attorney, Agent or Law Firm John L. Lemanowicz
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Patent number: 7592352Abstract: This invention relates to newly identified compounds for treating and preventing tumors and cancers, and methods for treating proliferative diseases associated with the imbalance or inappropriate activity of tyrosine kinases implicated in proliferative diseases.Type: GrantFiled: April 29, 2004Date of Patent: September 22, 2009Assignee: SmithKline Beecham CorporationInventor: Yasushi Miyazaki
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Patent number: 7582630Abstract: The present invention relates to pyrazaolpyradazine derivatives that inhibit GSK3 (glycogen synthase kinase), pharmaceutical compositions containing these derivatives, and methods for their use in the treatment of disorder characterized by misregulation of GSK3.Type: GrantFiled: October 14, 2003Date of Patent: September 1, 2009Assignee: SmithKline Beecham CorporationInventors: Scott Howard Dickerson, Francis Xavier Tavares, Huiqiang Zhou
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Patent number: 7507834Abstract: The present invention relates to anilinopyrazole derivatives, methods for the preparation of such anilinopyrazoles, and use of such anilinopyrazoles in the treatment of certain diseases or conditions. In particular, the present invention relates to a nilinopyrazole derivatives useful as CDK2 inhibitors and use of the anilinopyrazoles in the treatment of disorders mediated by inappropriate CDK2 activity.Type: GrantFiled: February 25, 2004Date of Patent: March 24, 2009Assignee: SmithKline Beechan CorporationInventor: Jun Tang
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Patent number: 7501512Abstract: This invention relates to newly identified inhibitors of kinases for treating various disorders.Type: GrantFiled: July 7, 2004Date of Patent: March 10, 2009Assignee: SmithKline Beecham CorporationInventors: Hideyuki Sato, Mio Takada, Yoshiaki Washio
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Patent number: 7482455Abstract: 3-carboxy quinoline derivatives, which are useful as YAK3 inhibitors are described herein. The described invention also includes methods of making such 3-carboxy quinoline derivatives as well as methods of using the same in the treatment of diseases mediated by inappropriate YAK3 activity.Type: GrantFiled: October 15, 2003Date of Patent: January 27, 2009Assignee: SmithKline Beecham CorporationInventors: Joelle L. Burgess, James F. Callahan, Toshihiro Hamajima, Satoru Ida, Ichiro Mori, Jun Tang
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Patent number: 7459455Abstract: Pyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.Type: GrantFiled: February 7, 2003Date of Patent: December 2, 2008Assignee: SmithKline Beecham CorporationInventors: Mui Cheung, Kristen Elizabeth Nailor, Douglas McCord Sammond, James Marvin Veal
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Patent number: 7449484Abstract: The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred.Type: GrantFiled: March 23, 2006Date of Patent: November 11, 2008Assignee: SmithKline Beecham CorporationInventors: Jerry L. Adams, Deborah L. Bryan
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Patent number: 7427623Abstract: Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.Type: GrantFiled: September 10, 2002Date of Patent: September 23, 2008Assignee: SmithKline Beecham CorporationInventors: Jerry Leroy Adams, Deborah Lynne Bryan, Yanhong Feng, Shinichiro Matsunaga, Yutaka Maeda, Yasushi Miyazaki, Masato Nakano, Jean-Philippe Rocher, Hideyuki Sato, Marcus Semones, Domingos J. Silva, Jun Tang
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Patent number: 7402606Abstract: Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.Type: GrantFiled: April 1, 2003Date of Patent: July 22, 2008Assignee: SmithKline Beecham CorporationInventors: David Gene Barrett, John G. Catalano, David Norman Deaton, Aaron Bayne Miller, John A. Ray, Vicente Samano
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Patent number: 7338959Abstract: Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.Type: GrantFiled: February 28, 2003Date of Patent: March 4, 2008Assignee: SmithKline Beecham CorporationInventors: Stanley Dawes Chamberlain, Mui Cheung, Holly Kathleen Emerson, Neil W. Johnson, Kristen Elizabeth Nailor, Douglas McCord Sammond, Marcus Semones
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Patent number: 7338966Abstract: The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.Type: GrantFiled: June 9, 2005Date of Patent: March 4, 2008Assignee: SmithKline Beecham CorporationInventors: Karen Elizabeth Lackey, Edgar Raymond Wood, III
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Patent number: 7329678Abstract: Benzimidazolyl-pyridine derivatives, which are useful as SGK-1 inhibitors are described herein. The described invention also includes methods of making such benzimidazolyl-pyridine derivatives as well as methods of using the same in the treatment of diseases mediated by inappropriate SGK-1 activity.Type: GrantFiled: January 27, 2004Date of Patent: February 12, 2008Assignee: SmithKline Beecham CorporationInventors: David Harold Drewry, Robert Neil Hunter, III
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Patent number: 7307097Abstract: Pyrazole derivatives are described herein. The described invention also includes methods of making such pyrazole derivatives as well as methods of using the same in the treatment of diseases.Type: GrantFiled: September 25, 2002Date of Patent: December 11, 2007Assignee: SmithKline Beechman CorporationInventors: Jerry Leroy Adams, Jiri Kasparec, Domingos J. Silva
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Patent number: 7300952Abstract: The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-? phosphorylation of I?B. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-?B in which diseases excessive activation of NF-?B is implicated.Type: GrantFiled: May 29, 2003Date of Patent: November 27, 2007Assignee: SmithKline Beecham CorporationInventors: James F. Callahan, Zehong Wan
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Patent number: 7282512Abstract: Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the treatment of disorders, including osteoporosis, associated with enhanced bone turnover which can ultimately lead to fracture.Type: GrantFiled: January 15, 2003Date of Patent: October 16, 2007Assignee: SmithKline Beecham CorporationInventors: John George Catalano, David Norman Deaton, Aaron Bayne Miller, Francis Xavier Tavares
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Patent number: 7279473Abstract: Fused pyradazine derivatives which are usefule as CDK inhibitors are described herein. The described invention alos includes methods of making such fused pyradazine derivatives as wells as methods of using the same in the treatment of hyperproliferative diseases.Type: GrantFiled: December 11, 2002Date of Patent: October 9, 2007Assignee: SmithKline Beecham CorporationInventors: Jennifer G. Badiang, Scott Howard Dickerson, Philip Anthony Harris, David Kendall Jung, Michael Robert Peel, Michael John Reno, Tara Renae Rheault, Kirk Lawrence Stevens, Francis Xavier Tavares, James Marvin Veal
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Patent number: 7276523Abstract: Aminopyridine derivatives of the following formula I which exhibit pharmacological activity at estrogen receptors alpha (ER?) and beta (ER?) are described herein. The described invention also includes compositions and medicaments containing the aminopyridine derivatives as well as processes for the preparation and use of such compounds, compositions and medicaments.Type: GrantFiled: March 20, 2002Date of Patent: October 2, 2007Assignee: SmithKline Beecham CorporationInventors: David Harold Drewry, Brad Richard Henke
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Patent number: 7265123Abstract: Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein tyrosine kinase inhibition.Type: GrantFiled: November 21, 2006Date of Patent: September 4, 2007Assignee: SmithKline Beecham CorporationInventors: George Stuart Cockerill, Karen Elizabeth Lackey
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Patent number: 7238813Abstract: Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.Type: GrantFiled: November 28, 2001Date of Patent: July 3, 2007Assignee: Smithkline Beecham CorporationInventors: Mui Cheung, Philip Anthony Harris, Masaichi Hasegawa, Satoru Ida, Kazuya Kano, Naohiko Nishigaki, Hideyuki Sato, James Marvin Veal, Yoshiaki Washio, Rob I. West
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Patent number: 7217710Abstract: Pyrazolo-pyrimidine derivatives are described herein. The described invention also includes methods of making such derivatives as well as methods of using the same in the treatment of diseases.Type: GrantFiled: October 1, 2002Date of Patent: May 15, 2007Assignee: SmithKline Beecham CorporationInventors: Jerry Leroy Adams, Jiri Kasparec, Domingos J. Silva, Catherine C. K. Yuan