Abstract: A computer system and method of operation has a retargeting program and apparatus which permits adding incorrectly targeted processors and a maintenance interface module (MIM) and automatically retargets them for the correct system. Each processor first determines its own system type, and the overall system type. Incorrectly targeted processors wait for retargeting, while correctly targeted processors select a master processor. The master processor retargets all incorrectly targeted processors by transferring an image of its correctly targeted firmware microcode into their RAM to be burned into their firmware. The MIM is retargeted using master processor code. Only accurately targeted or retargeted processors and MIM can be incorporated into the operating system.

Abstract: A surgical instrument in the form of a biopsy needle for removing tissue samples from a patient. The device has means for preloading to excise tissue samples of a preselected one of many possible tissue sample sizes. After preloading, the procedure is easily accomplished using a single hand. The tip is rendered less traumatic by positioning the distal end of the tissue sample notch relatively close to the very distal tip of the stylet. This is accomplished by grinding the distal tip of the stylet into an elliptical shape in a plane having a lateral projection which is away from the distal end of the tissue sample notch.

Abstract: An apparatus and method for transferring input/output information between a host computer and a peripheral device via fiber optic medium using the existing standard protocol designed to employ parallel electrical transmissions. In this manner, all of the advantages of fiber optic transmission, including EMI protection, lower power dissipation, small serial fiber optic cables, etc., are achieved without the need to modify any other system hardware or software elements. In the preferred mode, the Block Multiplexer Channel standard interface is modified for fiber optic transmission of both bus and tag information.

Abstract: A method of and apparatus for controlling one or more parameters of an electrical stimulation generator in response to measured results of the stimulation. In the preferred mode, this technique is employed in a system for the treatment of obstructive sleep apnea. Sensors are used to determine the effectiveness of the stimulation. Amplitude and pulse width are modified in response to the measurements from the sensors.

Abstract: Apparatus for and method of rapidly bringing a controlled space to a desired temperature. The technique is particularly applicable to the maintenance of controlled temperature spaces for the transportation of perishable cargo, such as in refrigeration trucks. Immediately following completion of the loading process, it is desirable to bring the internal temperature of the controlled space to the proper operating point as quickly as possible to retard spoilage. However, it is necessary to avoid unacceptable overshoot to prevent damage to the cargo by freezing. The disclosed system employs multiple sensors and a control algorithm to permit pull down to occur as rapidly as possible without unacceptable overshoot.

Abstract: An electrode for establishing electrical contact with nerve tissue. The electrode is chronically implantable. The outer substrate of the electrode is a semi-rigid, body compatible, insulating material such as a chronically implantable polymer. The outer substrate is molded as a single structure having a central spine along the longitudinal axis of the electrode. A plurality of fingers extend orthogonally from the central spine, and are bent circularly about a radius of curvature approximating that of the nerve to be contacted. Each of the plurality of fingers is of sufficient length to extend approximately one-half of the distance around the outer circumference of the nerve tissue. The plurality of fingers extend from the central spine in one of two opposite directions causing the electrode structure to encompass a hollow cylinder having an inside diameter the same as the nerve.

Abstract: A technique for reducing fatigue associated with artificially stimulated contractions of muscle tissue. The stimulation of the muscle tissue is associated with treatment of a particular medical condition, such as obstructive sleep apnea. For this application, the muscles of the upper airway are stimulated to relieve or prevent obstruction to normal respiratory activity during sleep.Fatigue is reduced by stimulating the subject muscles from multiple rather than a single electrode. This ensures that successive depolarizations are not produced from the same focus, and that different motor units are successively depolarized.Each electrode is placed at the muscle nerve interface to recruit the assistance of the nerve tissue in conducting the stimulation signals throughout the muscle. The conductors coupling the individual electrodes share a common cable structure to produce ease in the implant procedure. The electronics of the stimulation pulse generator is conveniently demultiplexed to eliminate excess hardware.

Abstract: A system for the treatment of obstructive sleep apnea packaged in a collar assembly with remote electrodes which can be worn by a patient without any special preparation. The collar assembly has an adjustable attachment means, such as hook and latch, to accommodate variations in neck size. The collar assembly is properly oriented using variations in physical shape and/or color. An optional feedback system permits the patient to readily verify proper orientation. The remote electrodes may be conveniently maintained in position using a mouthpiece or other means. Radio frequency signals are sent from the collar assembly to the remote electrodes to provide the therapy upon detection of an apnea event.

Abstract: A plurality of flow sensors are fabricated using thin film deposition techniques on a single substrate. The deposition is performed to provide the proper physical relationship of the individual sensors. In the preferred embodiment, the sensors are thermoresistive elements, which change resistance in response to the flow of air across the individual elements. The change in temperature of the air flow in relation to the ambient provides an indication of the flow and may be used to determine the extent of the flow. The resulting multiple sensor structure may be effectively used as a respiration detector by positioning a different sensor element at each of the airflow orifices (i.e. two nostrils and mouth) of a patient. The individual sensor elements may be electrically coupled in series.

Abstract: An apparatus for protecting an operator or maintenance person from electrical shock when working near power distribution facilities. The device is characterized by easily snapping off for access to the electrical circuitry and easily snapping on again to afford the desired protection. The shield is transparent providing the operator with visual access to the electrical circuitry at all times, even when the protective device is in place. The apparatus contains a transparent insulative plate attached to a suitable number of insulative clips. In the preferred mode, these clips are positioned to snap onto cartridge type fuses in a multiphase fuse panel. When snapped in place, the clips hold the transparent insulative plate between the electrical circuitry and the operator or maintenance person. Test points are drilled through the transparent insulative plate at appropriate locations to provide for the insertion of test probes when the protective device is in place.

Abstract: A stimulation lead for electrically coupling an implantable pulse generator to an electrode in an apnea treatment system and method of making same. The lead employs a thin substrate of polyurethane or other highly flexible implantable material. Conductors are placed on the substrate by silk screening a conductive ink. The ends of the lead are electrically terminated using rivets which couple through the substrate. The substrate is folded to enclose the conductors, thereby insulating them and protecting them from bodily fluids. Suitable connectors may be attached to either end. The resulting lead is easily fabricated and is extremely thin and flexible.

Abstract: An apparatus for and method of preoperative and intraoperative screening of obstructive sleep apnea patients. The screening device employs a plurality of stimulation channels which may be individually controlled to terminate or prevent an apnea event. The apparatus also contains a plurality of sensor processing channels to permit selection of the optimal sensor configuration and the sensing parameters. The preoperative procedure determines the suitability of a patient for therapy using an automatic implantable system. The type and placement of sensors and stimulation electrodes is also determined. During the intraoperative procedure, the initial screening determinations are verified and the various sensing and stimulation parameters are optimized.

Abstract: An implantable system for the treatment of obstructive sleep apnea by electrical stimulation of the musculature of the upper airway. The system employs one or more sensors to determine the onset of an apnea event. Upon sensing of the onset of an apnea event, the stimulation generator provides a signal for stimulating the muscles of the upper airway at a varying intensity wherein the intensity is gradually increased during the course of the stimulation. The signal is coupled to the muscles to be stimulated by an electrode connected to the stimulation generator by an insulated lead.

Abstract: A method of and apparatus for controlling one or more parameters of an electrical stimulation generator in response to measured results of the stimulation. In the preferred mode, this technique is employed in a system for the treatment of obstructive sleep apnea. Sensors are used to determine the effectiveness of the stimulation. Amplitude and pulse width are modified in response to the measurements from the sensors.

Abstract: Apparatus for and method of long-term control of the temperature within a refrigerated space, such as the cargo compartment of a refrigeration truck. The technique employs sensors which monitor both discharge and return air. A control algorithm uses the multiple sensors to control modes of a refrigeration unit capable of supplying cooled or heated air. This causes the temperature within the refrigerated space to remain within a narrow range about a target temperature. The target is chosen to provide maximum safety for the cargo. If the target temperature is too high, the cargo is needlessly exposed to spoilage. If the target temperature is too low, the cargo is subject to the risk of damage from freezing.

Abstract: An improved apparatus for and method of providing feedback to an implantable pulse generator to treat obstructive sleep apnea. Sensors monitor the electrical activity associated with contractions of the diaphragm. The pressure within the thorax and the upper airway are also measured. Whenever electrical activity of the diaphragm suggests that an inspiration cycle is in progress and the pressure sensors show an abnormal pressure differential across the airway, the presence of obstructive sleep apenea is assumed and electrical stimulation is applied to the musculature of the upper airway.

Abstract: A strain gauge and method of making same for use in certain medical applications, such as sensing the occurrence of an apnea event. The device is also applicable to monitoring mechanical motion associated with other medical conditions. The strain gauge actually measures the change in direct current resistance produced by stretching and compression of a number of carbon deposits coupled in series on a longitudinally extendible substrate. This extendibility is produced by suitably die cutting a flexible but inherently inelastic insulative substrate. The easily produced device may be used externally or encapsulated for implantation.

Abstract: A plurality of flow sensors are fabricated on a single substrate. The substrate is laid out to provide the proper physical relationship of the individual sensors. The resulting multiple sensor structure may be effectively used as a respiration detector by positioning a different sensor element at each of the airflow orifices (i.e., two nostrils and mouth) of a patient. In the preferred embodiment, the sensors are thermoresistive elements, which are screened on the substrate using conductive ink. The change in temperature of the air flow in relation to the ambient at each orifice provides an indication of the flow and may be used to determine the extent of the flow. The substrate is packaged in a single piece adhesive strip which provides ease of proper attachment by the patient.

Abstract: An apparatus for and method of improving muscle tone of a patient using chronic sub-tetanic electrical stimulation. For patients suffering from obstructive sleep apnea, for example, the muscles of the upper airway are provided the chronic stimulation to mitigate or prevent the adverse medical condition caused in part by excessively flaccid muscle tissue around and in the airway.A stimulation generator supplies pulses to the muscle to be treated through insulated leads which are coupled to electrodes directly in contact with the appropriate neuro-muscular tissue. The output of the stimulation generator is adjusted to a frequency of sufficiently low level as to prevent fused tetanic contraction of the stimulated muscle. The adjustment may be made manually by attending medical personnel or may be done automatically using electrodes to sense the tension of the stimulated muscle. In the automatic mode, the sensing system insures the stimulation frequency level is decreased below the threshold of muscle tetanus.

Abstract: A technique for protecting an implantable drug administration device from damage caused by over filling. The protection is implemented using an automatic valve positioned between the puncturable sealing septum and the reservoir. This automatic valve is operated volumetrically by coupling the valve actuator to the diaphragm which separates the drug chamber from the fluid volume compensation chamber. When the diaphragm flexes to the maximum fill position, the valve actuator closes the automatic valve, thus prohibiting any further transfer to the reservoir.