Patents Represented by Attorney John R. Storella
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Patent number: 6046307Abstract: The invention relates to peptide nucleic acids that inhibit telomerase activity in mammalian cells.Type: GrantFiled: April 9, 1997Date of Patent: April 4, 2000Assignee: The University of Texas SystemInventors: Jerry W. Shay, Woodring E. Wright, Mieczyslaw A. Piatyszek, David R. Corey, James C. Norton
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Patent number: 6015710Abstract: The invention relates to peptide nucleic acids that modulate telomerase activity in mammalian cells.Type: GrantFiled: April 9, 1996Date of Patent: January 18, 2000Assignee: The University of Texas SystemInventors: Jerry W. Shay, Woodring E. Wright, Mieczyslaw A. Piatyszek, David R. Corey, James C. Norton
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Patent number: 5965543Abstract: Recombinant polynucleotides have expression control sequences that have a senescence responsive element and a minimal promoter, and which are operatively linked to a heterologous nucleotide sequence. The molecules are useful for achieving high levels of expression of genes in senescent cells. Methods of inhibiting expression of genes in senescent cells also are provided.Type: GrantFiled: April 17, 1997Date of Patent: October 12, 1999Assignee: Geron CorporationInventors: Judith Campisi, Alessandro Testori
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Patent number: 5958680Abstract: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.Type: GrantFiled: June 7, 1995Date of Patent: September 28, 1999Assignee: Geron CorporationInventors: Bryant Villeponteau, Junli Feng, Walter Funk, William H. Andrews
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Patent number: 5846723Abstract: Methods of detecting the RNA component of telomerase, diagnosing cancer, and determining its prognosis using polynucleotides that hybridize to the RNA component of mammalian telomerase in a sample.Type: GrantFiled: December 20, 1996Date of Patent: December 8, 1998Assignee: Geron CorporationInventors: Nam Woo Kim, Fred Wu, James T. Kealey, Ronald Pruzan, Scott L. Weinrich
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Patent number: 5776679Abstract: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.Type: GrantFiled: June 7, 1995Date of Patent: July 7, 1998Assignee: Geron CorporationInventors: Bryant Villeponteau, Junli Feng, Walter Funk, William H. Andrews
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Patent number: 5605811Abstract: The present invention provides methods for identifying beta amyloid production inhibitors, wherein cells are cultured under conditions which result in secretion of a soluble fragment of beta amyloid precursor protein. The amino acid sequence of the fragment extends from the amino terminus of beta APP to the amino terminus of the beta amyloid peptide. The cultured cells are exposed to test compounds which cause a change in the secreted amount of the soluble fragment of beta APP which is determined.Type: GrantFiled: May 12, 1995Date of Patent: February 25, 1997Assignees: Athena Neurosciences, Inc., Eli Lilly and CompanyInventors: Peter A. Seubert, Dale B. Schenk, Lawrence C. Fritz
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Patent number: 5589483Abstract: Inhibition of the enzyme poly (ADP-ribose) polymerase can delay the onset of senescence and inhibitors of the enzyme can be used to treat diseases caused or exacerbated by cellular senescence.Type: GrantFiled: December 21, 1994Date of Patent: December 31, 1996Assignee: Geron CorporationInventor: Michael D. West
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Patent number: 5583016Abstract: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.Type: GrantFiled: October 27, 1994Date of Patent: December 10, 1996Assignee: Geron CorporationInventors: Bryant Villeponteau, Junli Feng, Walter Funk, William H. Andrews
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Patent number: 5272263Abstract: DNA sequences encoding vascular cell adhesion molecules 1 and 1b ("VCAM1" and "VCAM1B"), recombinant DNA molecules comprising those sequences, and unicellular hosts transformed with those recombinant DNA molecules.Type: GrantFiled: December 18, 1989Date of Patent: December 21, 1993Assignee: Biogen, Inc.Inventors: Catherine A. Hession, Roy R. Lobb, Susan E. Goelz, Laurelee Osborn, Christopher D. Benjamin, Margaret D. Rosa
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Patent number: 5217870Abstract: Monoclonal antibodies against CDX, a leukocyte cell surface molecule that is a ligand of ELAM 1, and methods for producing them. Monoclonal antibody SGB.sub.3 B.sub.4 and monoclonal antibodies reactive to the same epitope. These monoclonal antibodies inhibit leukocyte-endothelial cell adhesion.Type: GrantFiled: April 28, 1989Date of Patent: June 8, 1993Assignee: Biogen, Inc.Inventors: Catherine A. Hession, Roy R. Lobb, Susan E. Goelz
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Patent number: 5202042Abstract: An electrolyte for an electrolytic capacitor is disclosed, containing a carboxylic acid salt of a cationic nitrogen-containing heterocyclic compound as solute within an aprotic solvent or a mixed solvent comprising major aprotic solvent and minor polyol solvent.Type: GrantFiled: July 3, 1991Date of Patent: April 13, 1993Assignee: Nippon Chemi-Con CorporationInventors: Tatsunori Tsuji, Makoto Shimizu, Fumihiko Shinozaki, Yutaka Yokoyama
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Patent number: 5115823Abstract: I disclose a flavor-enhancing smoking filter having at least two zones, including at least one filtering zone and at least one flavor-enhancing zone. The flavor-enhancing zone(s) have a flavorant, have a surface providing for the substantially laminar flow of smoke and permit the passage of none or a minority of the smoke drawn through the filter.Type: GrantFiled: December 20, 1990Date of Patent: May 26, 1992Assignee: Philip Morris IncorporatedInventor: Gus D. Keritsis
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Patent number: 5021244Abstract: A method of sorting living cells based on DNA content. Mammalian sperm subpopulations enriched in X- or Y-sperm. X- and Y-enriched sperm-plasma-membrane vesicles. Substantially pure sex-associated membrane (SAM) proteins. Antibodies binding to X- or Y-SAM proteins, essentially free of antibodies binding to Y- or X-SAM proteins respectively, or to the H-Y antigen. Semen samples enriched for X- or Y-sperm. Methods for increasing the probability that offspring will be male or female comprising the step of allowing as perm from an enriched semen sample to fertilize an ovum. Methods for increasing the probability that offspring will be male or female comprising the step of immunizing a female with X- or Y-SAM proteins. Methods of decreasing fertility comprising the step of immunizing a female with both X- and Y-sperm. Methods of increasing the probability that mammalian offspring will carry a gene for a particular sex-chromosome linked trait.Type: GrantFiled: May 12, 1989Date of Patent: June 4, 1991Assignee: Cytogam, Inc.Inventor: Glenn F. Spaulding
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Patent number: 4945052Abstract: An enzyme for conversion of 2,5-diketo-D-gluconate (2,5-DKG) to 2-keto-L-gulonic acid (2-KLG) and a genetically modified organism that expresses all the fermentation enzymes needed to convert glucose to 2-KLG (a precursor to ascorbic acid) using the new enzyme are described. Preferably, the organism is Erwinia citreus, or a mutated strain of Erwinia citreus, unable to use 2,5-DKG or 2-KLG as a sole carbon source, into which the gene for a 2,5-DKG reductase, produced by Corynebacterium sp., SHS 752001, has been inserted. The preferred transformed organism expresses the fermentation enzymes Erwinia citreus normally expresses for fermentation of glucose to 2,5-DKG and, in addition, an enzyme Corynebacterium sp. SHS 752001 expresses for fermentation of 2,5-DKG to 2-KLG.Type: GrantFiled: June 2, 1987Date of Patent: July 31, 1990Assignee: Biogen, Inc.Inventors: Kimber Hardy, Hendrick van de Pol, June Grindley, Mark A. Payton
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Patent number: 4930344Abstract: An apparatus for testing the quality of a seal on a package overwrap having a cutting or burning element to create a hole in the package overwrap without breaching the integrity of the package; a measuring head for introducing super-atmospheric air pressure through the hole between the overwrap and the package; and a pressure transducer for determining whether the rate of air leakage from the overwrap is within acceptable limits.Type: GrantFiled: March 30, 1989Date of Patent: June 5, 1990Assignee: Philip Morris IncorporatedInventors: J. Jerome Fleenor, Christopher N. Chance, Robert T. Mitten