Patents Represented by Attorney Joseph F. DiPrina

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  • Inhibitors of farnesyl protein transferase
    Patent number: 5340828
    Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: September 30, 1991
    Date of Patent: August 23, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Samuel L. Graham, S. Jane deSolms