Abstract: A method of treating sexual dysfunction comprising administering a therapeutically effective amount of a combination of phentolamine and apomorphine, as well as pharmaceutical compositions and kits useful in those methods, are disclosed.
Abstract: Novel tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
Type:
Grant
Filed:
September 11, 1997
Date of Patent:
June 6, 2000
Assignee:
Schering Corporation
Inventors:
F. George Njoroge, Yi-Tsung Liu, Arthur G. Taveras
Abstract: A method of treating sexual dysfunction comprising administering a therapeutically effective amount of a combination of phentolamine and apomorphine, as well as pharmaceutical compositions and kits useful in those methods, are disclosed.
Abstract: A method of treating sexual dysfunction comprising administering a therapeutically effective amount of a combination of phentolamine and apomorphine, as well as pharmaceutical compositions and kits useful in those methods, are disclosed.
Abstract: Novel tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
Type:
Grant
Filed:
September 11, 1997
Date of Patent:
October 12, 1999
Assignees:
Schering Corporation, Pharmacopeia Inc.
Inventors:
Alan B. Cooper, Alan K. Mallams, Viyyoor M. Girijavallabhan, Ronald J. Doll, Arthur G. Taveras, F. George Njoroge, John J. Baldwin, John C. Reader
Abstract: Process for preparing a key intermediate, 2-methyl-3-trifluoromethylaniline (MTA) of Flunixin, as well as novel intermediates thereof are described.
Abstract: Novel tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
Type:
Grant
Filed:
September 11, 1997
Date of Patent:
September 28, 1999
Assignee:
Schering Corporation
Inventors:
Dinanath F. Rane, Alan B. Cooper, Alan K. Mallams, Ronald J. Doll, F. George Njoroge, Arthur G. Taveras
Abstract: The present invention is directed towards a method, a composition and an article of manufacture for protecting the skin from jellyfish stings. The method comprises topically contacting the skin with a composition containing polymeric quaternary ammonium salt in amounts sufficient to protect against the rupture of jellyfish nematocysts. The composition can be in the form of an emulsion, liquid dispersion, solution, skin cream, face cream, lotion or ointment.
Type:
Grant
Filed:
July 21, 1997
Date of Patent:
September 28, 1999
Assignees:
Schering-Plough HealthCare Products, Inc., University of Maryland, Baltimore
Inventors:
Richard V. Smerbeck, James R. Johnson, Joseph W. Burnett, Jennifer E. Purcell
Abstract: Stable sulfide-containing compositions have been developed. The stable sulfide-containing composition comprises a) a sulfide, a polysulfide or mixtures thereof, of an alkali or an alkaline earth metal, and b) a carrier, such that after maintaining the sulfide-containing composition at a temperature of about 37.degree. to about 50.degree. Celsius for about 2 weeks to one month, the sulfide content remaining in the sulfide-containing composition is about 90% or greater of the initial sulfide content. The sulfide-containing compositions can be used for relieving the pain of ingrown toenail by softening the nail, or as a depilatory for removing human hair or hair from animal hides.
Type:
Grant
Filed:
May 26, 1995
Date of Patent:
September 7, 1999
Assignee:
Schering-Plough HealthCare Products, Inc.
Inventors:
Joseph A. Haslwanter, Gerald R. Dever, Thomas J. Laughlin
Abstract: Novel aminooxyamide tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
Abstract: Novel tricyclic N-cyanoimine compounds and pharmaceutical compositions of formula (1.0) ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein a, b, c, d, R.sup.1 -R.sup.8, X and Z are defined herein. Such compounds are inhibitors of the enzyme, farnesyl protein transferase. The compounds are useful for inhibiting Ras function and therefore inhibiting the abnormal growth of cells, in a mammals such as a human.
Type:
Grant
Filed:
July 29, 1997
Date of Patent:
July 20, 1999
Assignee:
Schering Corporation
Inventors:
Alan B. Cooper, James J-S Wang, Raymond G. Lovey, Jagdish A. Desai, Anil K. Saksena, Viyyoor M. Girijavallabhan, Ronald J. Doll
Abstract: An article comprising a soft, polysiloxane elastomer having a hardness of 5-55 durometer units (Shore 00), the elastomer having a pressure sensitive adhesive on at least one of its surfaces is described. A process for bonding a pressure sensitive adhesive to the soft polysiloxane elastomeric is also described.
Type:
Grant
Filed:
May 26, 1995
Date of Patent:
July 13, 1999
Assignee:
Schering-Plough HealthCare Products, Inc.
Inventors:
Ronald L. Bracken, Gerald R. Dever, Ronald M. Feret, Daniel B. Snyder
Abstract: Novel carbonyl piperazinyl and piperidinyl compounds and pharmaceutical compositions are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel carbonyl piperazinyl or piperidinyl compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
Type:
Grant
Filed:
May 8, 1996
Date of Patent:
March 9, 1999
Assignees:
Schering Corporation, Pharmacopeia Inc.
Inventors:
Ronald J. Doll, Alan K. Mallams, Adriano Afonso, Dinanth F. Rane, George F. Njoroge, Randall R. Rossman, John J. Baldwin, Ge Li, John C. Reader