Patents Represented by Attorney Jospeh F. DiPrima

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  • Cysteine-modified acidic fibroblast growth factor and methods of use
    Patent number: 5409897
    Abstract: Mutant human acidic fibroblast growth factor proteins are recombinantly produced having replaced cysteine residues with amino acids incapable of disulfide bond formation. The recombinantly produced mutant human acidic fibroblast growth factor proteins have improved biological activity in the absence of heparin when compared to wild-type recombinant human acidic fibroblast growth factor.
    Type: Grant
    Filed: January 31, 1994
    Date of Patent: April 25, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth A. Thomas, David L. Linemeyer