Patents Represented by Attorney Joy Ann Serauskas

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  • Phenyl amidine alkanoic acids useful as platelet aggregation inhibitors
    Patent number: 5646183
    Abstract: This invention relates to phenyl amidine alkanoic acids and lactones having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine derivatives.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: July 8, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Norman Anthony Abood, Robert Everett Manning, Masateru Miyano
  • Process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-penty noate
    Patent number: 5631399
    Abstract: The present invention relates to a novel process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentyno ate and pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: May 14, 1996
    Date of Patent: May 20, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Kevin A. Babiak, Srinivasan Babu, James R. Behling, Mark L. Boys, Kimberly J. Cain-Janicki, Wendel W. Doubleday, Payman Farid, Timothy J. Hagen, E. A. Hallinan, Donald W. Hansen, Jr., Donald E. Korte, Kathleen T. Mc Laughlin, John R. Medich, Sean T. Nugent, Vlasdislav Orlovski, Jung M. Park, Karen B. Peterson, Daniel R. Pilipauskas, Barnett S. Pitzele, Sofya Tsymbalov, Glenn L. Stahl
  • Phenyl amidine lactones useful as platelet aggregation inhibitors
    Patent number: 5612355
    Abstract: This invention relates to phenyl amidine alkanoic acids and lactones having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine derivatives.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: March 18, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Robert E. Manning, Masateru Miyano
  • Peptide mimetic compounds useful as platelet aggregation inhibitors
    Patent number: 5552431
    Abstract: This invention relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions--of such phenyl amidines derivatives.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: September 3, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Robert B. Garland, Masateru Miyano
  • Method of inhibiting platelet aggregation using phenyl amidine thio derivatives
    Patent number: 5543425
    Abstract: This invention relates to a method of inhibiting platelet aggregation comprising administering compounds having the following formula ##STR1##
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: August 6, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Steven P. Adams, Richard J. Lindmark, Masateru Miyano, Joseph G. Rico
  • Process for the preparation of ethyl 3S-[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentyn oate
    Patent number: 5536869
    Abstract: The present invention relates to a novel process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentyno ate and pharmaceutically acceptable acid addition salt thereof which comprises treating (trimethylsilyl)acetylene sequentially with n-butyllithium and 4-formylmorpholine followed by acid hydrolysis to give 3-(trimethylsilyl)-2-propynal; treating 3-(trimethylsilyl)-2-propynal with lithium bis(trimethylsilyl)amide to give in situ N,3-bis(trimethylsilyl)-2-propyn-1-imine; condensation of N,3-bis(trimethylsilyl)-2-propyn-1-imine with lithium t-butyl acetate to give (.+-.)1,1-dimethylethyl 3-amino-5-(trimethylsilyl)-4-pentynoate; treating (.+-.)1,1-dimethylethyl 3-amino-5-(trimethylsilyl)-4-pentynoate- with p-toluenesulfonic acid to give (.+-.)1,1-dimethylethyl 3-amino-5-(trimethylsilyl)-4-pentynoate, mono p-toluenesulfonic acid salt, treatment of resulting salt with ethanol in the presence of p-toluenesulfonic acid to give (.+-.
    Type: Grant
    Filed: July 14, 1995
    Date of Patent: July 16, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Kevin A. Babiak, Srinivasan Babu, James R. Behling, Mark L. Boys, Kimberly J. Cain-Janicki, Wendel W. Doubleday, Payman Farid, Timothy J. Hagen, E. Ann Hallinan, Donald W. Hansen, Jr., Donald E. Korte, Kathleen T. McLaughlin, John R. Medich, Sean T. Nugent, Vlasdislav Orlovski, Jung M. Park, Karen B. Peterson, Daniel R. Pilipauskas, Barnett S. Pitzele, Sofya Tsymbalov, Glenn L. Stahl
  • Phenyl amidine alkanoic acids and lactones useful as platelet aggregation inhibitors
    Patent number: 5504106
    Abstract: This invention relates to phenyl amidine alkanoic acids and lactones having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine derivatives.
    Type: Grant
    Filed: July 21, 1994
    Date of Patent: April 2, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Robert E. Manning, Masateru Miyano
  • Phenyl amidines lactones useful as platelet aggregation inhibitors
    Patent number: 5441974
    Abstract: This invention relates to compounds having the following formula ##STR1## wherein Z is a lactone or a lactone which is fused to a benzene ring which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidines derivatives.
    Type: Grant
    Filed: May 25, 1994
    Date of Patent: August 15, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Philippe R. Bovy, Thomas E. Rogers, Masateru Miyano, Joseph G. Rico
  • Peptide mimetic compounds useful as platelet aggregation inhibitors
    Patent number: 5424334
    Abstract: This invention relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions--of such phenyl amidines derivatives.
    Type: Grant
    Filed: December 19, 1991
    Date of Patent: June 13, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Robert B. Garland, Masateru Miyano
  • N-substituted lactams useful as cholecystokinin antagonists
    Patent number: 5314886
    Abstract: This invention relates to novel N-substituted lactams having the following formula ##STR1## useful in the treatment and prevention of Cholecystokinin (CCK) related disorders of the gastrointestinal, central nervous and appetite regulatory systems of mammals.
    Type: Grant
    Filed: October 29, 1992
    Date of Patent: May 24, 1994
    Assignee: G. D. Searle & Co.
    Inventors: Daniel P. Becker, Daniel L. Flynn, Clara I. Villamil
  • 5-substituted imidazo[4,5-c]pyridines
    Patent number: 5302601
    Abstract: The present invention relates to a class of compounds represented by the formula ##STR1## or a pharmaceutically acceptable salt thereof useful in the treatment of diseases or disorders mediated by platelet activating factor (PAF).
    Type: Grant
    Filed: November 6, 1992
    Date of Patent: April 12, 1994
    Assignee: G. D. Searle & Co.
    Inventors: Ish K. Khannal, Roger Nosal, Richard M. Weier, Kirk T. Lentz
  • Process for the resolution of (.+-.)-.alpha.-[2-[acetyl(1-methylethyl)amino]ethyl]-.alpha.-(2-chloroph enyl)-1-piperidinebutanamide
    Patent number: 5276155
    Abstract: A process for the resolution of (.+-.)-.alpha.-[2-[acetyl(1-methylethyl)amino]ethyl-.alpha.-(2-chloropheny l)-1-piperidinebutanamide having the following structure ##STR1## into its (+) and (-) enantiomers using camphorsulfonic acid.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: January 4, 1994
    Assignee: G. D. Searle & Co.
    Inventors: John R. Medich, Gatis Plume
  • Phenyl amidines sulfonamides useful as platelet aggregation inhibitors
    Patent number: 5264457
    Abstract: This invention relates to compounds having the following formula ##STR1## which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine sulfones derivatives.
    Type: Grant
    Filed: February 14, 1992
    Date of Patent: November 23, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Steven P. Adams, Joseph G. Rico, Masateru Miyano
  • Metabolites of pentanedioic acid derivatives
    Patent number: 5233063
    Abstract: The present invention relates to pentanedioic acid derivatives. The present invention further relates to pharmaceutical compositions containing such compounds and the use of such compounds and compositions as hypolipidemic drugs.
    Type: Grant
    Filed: January 16, 1991
    Date of Patent: August 3, 1993
    Assignee: G. D. Searle & Co.
    Inventors: John S. Baran, Harman S. Lowrie
  • 5-substituted [4,5-c] imidazopyridines and pharmaceutical use thereof
    Patent number: 5227384
    Abstract: The present invention relates to a class of compounds represented by the formula ##STR1## or a pharmaceutically acceptable salt thereof useful in the treatment of diseases or disorders mediated by platelet activating factor (PAF).
    Type: Grant
    Filed: March 15, 1991
    Date of Patent: July 13, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Ish K. Khanna, Roger Nosal, Richard M. Weier
  • Peptide mimetic compounds useful as platelet aggregation inhibitors
    Patent number: 5220050
    Abstract: This invention relates to having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidines derivatives.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: June 15, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Philippe R. Bovy, Dudley E. McMackins, Joseph G. Rico, Foe S. Tjoeng, Mihaly V. Toth, Robert B. Garland, Masateru Miyano, Jeffery A. Zablocki
  • Substituted N-benzylpiperidine amides and cardiac regulatory compositions thereof
    Patent number: 5210090
    Abstract: The invention relates to compound of the formula ##STR1## useful in regulating cardiac arrhythmias. This invention also relates to pharmaceutical compositions of the above-described compounds.
    Type: Grant
    Filed: August 27, 1990
    Date of Patent: May 11, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Bipinchandra N. Desai, Mark A. Russell
  • 5-substituted-4-phenyl-5H-imidazo[4,5-c]pyridine derivatives
    Patent number: 5208242
    Abstract: The present invention relates to a class of 5-substituted-4-phenyl-5H-imidazo[4-phenyl-5H-imidazo[ 4,5-c]pyridines represented by the formula ##STR1## or a pharmaceutically acceptable salt thereof useful in the treatment of diseases or disorders mediated by platelet activating factor (PAF).
    Type: Grant
    Filed: August 26, 1992
    Date of Patent: May 4, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Ish K. Khanna, Richard M. Weier
  • Thiohydantoin inhibitors of collagen-induced and ADP-induced platelet aggregation
    Patent number: 5137904
    Abstract: A series of ethers and thioethers of 5-methanol thiohydantoins, unsubstituted at the number one position heterocyclic nitrogen atom of the thiohydantoin ring, useful in reversing the effects of collagen and ADP-induced platelet aggregation.
    Type: Grant
    Filed: May 30, 1989
    Date of Patent: August 11, 1992
    Assignee: G. D. Searle & Co.
    Inventors: John S. Baran, Tom Lindberg, Robert H. Mazur, Alan E. Moorman, Doug Steinman
  • Cyanoquanidine type III antiarrhythmic agents and use
    Patent number: 5132311
    Abstract: Cyanoguanidines which have activity as Class III antiarrhythmic agents, acting by prolonging cardiac action potential repolarization. The invention further provides for compositions incorporating the compounds and methods of their use, as well as providing for pharmaceutically acceptable salts of the compounds.
    Type: Grant
    Filed: July 30, 1991
    Date of Patent: July 21, 1992
    Assignee: G. D. Searle & Co.
    Inventor: Chi-Dean Liang