Abstract: Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.

Abstract: The multi-ported valve assembly includes a valve body having a plurality of individual ports disposed in a common plane and a common port having its axis disposed perpendicularly to the common plane of the individual ports. The valve assembly includes a selector means having a body portion designed to engage the valve body and provide selective communication between one of the individual ports and the common port. The selector means includes a handle to facilitate rotation thereof and selection of a desired fluid flow passageway as well as indicator means to indicate direction of fluid flow. Also provided are sealing means to prevent external leakage during use and suitable connecting or coupling means to provide connection especially in devices and apparatus used in ophthalmic surgical procedures.

Abstract: Disclosed are nonstinging, sustained release ophthalmic formulations. The formulations comprise a cationic drug, an acidic mucomimetic polymer and a polystyrene sulfonic acid polymer. In particular, formulations for the control of intraocular pressure and glaucoma are disclosed. Methods for use of the formulations are also disclosed.