Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for APP.
Type:
Grant
Filed:
November 4, 2009
Date of Patent:
November 9, 2010
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.
Type:
Grant
Filed:
March 18, 2005
Date of Patent:
October 26, 2010
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Stephen Scaringe, Steven Read
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for proto-oncogene MET.
Type:
Grant
Filed:
November 2, 2009
Date of Patent:
October 19, 2010
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: The invention relates to a process for the coating of a catalyst support with a catalytically active coat using a coating dispersion, the catalyst support containing at least two partial structures which differ in their absorptivity for the coating dispersion. The process is characterized in that the absorptivity of the partial structures is modified relative to one another by precoating of the catalyst support with a material which can be burnt out or with liquid, and the catalytic coat is then applied to the filter body in a known manner, dried and/or calcined.
Type:
Grant
Filed:
November 4, 2003
Date of Patent:
October 12, 2010
Assignee:
Umicore AG & Co. KG
Inventors:
Rainer Domesle, Thomas Kreuzer, Egbert Lox
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Through these methodologies, one can select siRNA that target genes, including surviving.
Type:
Grant
Filed:
September 10, 2009
Date of Patent:
October 5, 2010
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Stephen Scaringe, Steven Read
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for BACE.
Type:
Grant
Filed:
December 11, 2009
Date of Patent:
October 5, 2010
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TAF1.
Type:
Grant
Filed:
November 12, 2009
Date of Patent:
September 28, 2010
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: The invention relates to a catalyst arrangement for purifying the exhaust gases of internal combustion engines operated under lean conditions. It is proposed that a thinwalled, porous carrier be coated on one side with a nitrogen oxide storage catalyst and on the other side with an SCR catalyst. When the exhaust gas is passed through the catalytic coatings and the support material, a significant improvement in the nitrogen oxide conversion is achieved compared to a series arrangement of the catalysts on separate carriers. Wall flow filters have been found to be useful as thin-walled carriers.
Type:
Grant
Filed:
July 29, 2004
Date of Patent:
September 21, 2010
Assignee:
Umicore AG & Co. KG
Inventors:
Marcus Pfeifer, Nicola Soeger, Yvonne Demel, Tobias Kuhl, Paul Christian Spurk, Jürgen Gieshoff, Egbert Lox, Thomas Kreuzer
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for APOB.
Type:
Grant
Filed:
October 29, 2007
Date of Patent:
September 14, 2010
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing Bcl-2.
Type:
Grant
Filed:
October 17, 2007
Date of Patent:
September 14, 2010
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Stephen Scaringe, Steven Read
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.
Type:
Grant
Filed:
September 18, 2009
Date of Patent:
August 24, 2010
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: In automotive exhaust gas catalysts with a metallic honeycomb composed of corrugated and smooth sheet layers, it is known that the heat capacity and thermal conductivity of the honeycomb can be reduced by perforations in the sheet layers. As a result, the honeycomb heats up more rapidly and the catalytic coating applied on the honeycomb reaches its operating temperature more rapidly. A disadvantage here is the reduction in the support surface area by the perforations in the sheet layers. According to the invention, suitable adjustment of the properties of the coating suspension used for the catalytic coating and of the dimensions of the holes relative to one another allows the holes to be filled permanently with catalyst material. The resulting catalyst has, at the same coating concentration as a catalyst with unperforated sheet layers, a significantly reduced heat capacity and thermal conductivity.
Abstract: A no-clean low residue solder paste is described for die-attach dispensing or fine pitch printing of semiconductor devices. The solder paste has a homogeneous consistency with no tendency to paste separation. The ultimately remaining residue is clear and crystal like and is compatible with further processing steps without prior cleaning with a solvent to remove flux residue. The solder paste comprises a relatively low amount of rosin in combination with a viscous solvent system, thixotropic agents, activators, additives and optionally plasticizers.
Type:
Grant
Filed:
June 30, 2006
Date of Patent:
August 3, 2010
Assignee:
W.C. Heraeus Holding GmbH
Inventors:
Quan Sheng, Muriel Thomas, Jens Nachreiner