Abstract: Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
Type:
Grant
Filed:
March 31, 1997
Date of Patent:
December 1, 1998
Assignees:
The Leland Stanford Junior University, The John Innes Institute
Inventors:
Chaitan Khosla, David A. Hopwood, Susanne Ebert-Khosla, Robert McDaniel, Hong Fu
Abstract: Drug delivery systems for the transdermal administration of tamsulosin are described. The systems are in the form of laminated patches having one or more reservoirs comprised of a polymeric adhesive material containing a tamsulosin formulation. The invention also relates to a method for treating benign prostatic hypertrophy (BPH) and related conditions and diseases, by administering tamsulosin transdermally, to tamsulosin-containing pharmaceutical compositions for transdermal administration of the drug and to a low-temperature method for manufacturing a tamsulosin-containing transdermal delivery system.
Type:
Grant
Filed:
February 28, 1997
Date of Patent:
December 1, 1998
Assignee:
Cygnus, Inc.
Inventors:
Xinghang Ma, Jay Audett, Pravin L. Soni, Noel Singh, Susan E. Bailey