Patents Represented by Attorney, Agent or Law Firm Kenneth W. Peist
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Patent number: 6855698Abstract: The present invention relates to fluoro sugar and other sugar derivatives of indolopyrrolocarbazoles, their salts and hydrates, which exhibit selective topoisomerase I (topo I) activity, are useful in inhibiting the proliferation of tumor cells and exhibit an antitumor effect, as well as processes for their preparation.Type: GrantFiled: March 22, 2002Date of Patent: February 15, 2005Assignee: Bristol-Myers Squibb CompanyInventors: Edward H. Ruediger, Mark G. Saulnier, Francis Beaulieu, Carol Bachand, Neelakantan Balusubramanian, Byron Hepler Long, David B. Frennesson, Kurt Zimmermann, B. Narasimhulu Naidu, Karen Stoffan, Denis Robert St. Laurent
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Patent number: 6750246Abstract: The present invention concerns novel taxane derivatives, their use as antitumor agents, and pharmaceutical formulations. The invention claims compounds of formula I and the use of compounds of formula I or pharmaceutical salts thereof as oral drugs for the treatment of human or veterinary disease. in which: R is phenyl, isopropyl, or tert butyl; R1 is —C(O)Rz in which Rz is (CH3)3CO—, (CH3)3CCH2—, CH3(CH2)3O—, cyclobutyl-, cyclohexyloxy, or (2-furyl); R2 is CH3C(O)O—.Type: GrantFiled: November 14, 2000Date of Patent: June 15, 2004Assignee: Bristol-Myers Squibb CompanyInventors: John F. Kadow, Harold Mastalerz, Qiufen May Xue, Steven Hansel, Mary Edson Zoeckler, William C. Rose, James G. Tarrant
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Patent number: 6737254Abstract: A method for extracting taxanes such as taxol, including the use of supercritical fluids.Type: GrantFiled: September 13, 2001Date of Patent: May 18, 2004Assignee: Bristol-Myers Squibb CompanyInventor: Jayaprakash B. Nair
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Patent number: 6686385Abstract: The present invention concerns novel sugar derivatives of indolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.Type: GrantFiled: May 7, 2003Date of Patent: February 3, 2004Assignee: Bristol-Myers Squibb CompanyInventors: Mark G. Saulnier, Edward H. Ruediger, Neelakantan Balasubramanian, David Bertil Frennesson, Mikael Mahler, Kurt Zimmermann
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Patent number: 6677450Abstract: The present invention relates to novel N12, N13-bridged sugar derivatives of indolylopyrrolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.Type: GrantFiled: September 27, 2001Date of Patent: January 13, 2004Assignee: Bristol-Myers Squibb CompanyInventors: Mark G. Saulnier, Edward H. Ruediger, Neelakantan Balasubramanian, Mikael Mahler, Francis Beaulieu, Carol Bachand, David B. Frennesson
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Patent number: 6541242Abstract: Methods for the enzymatic resolution of mixtures of enantiomers, such as &bgr;-lactam compounds, which may be employed as intermediates in the preparation of taxanes bearing a C-13 sidechain containing a heterocyclic or cycloalkyl group, the latter useful in the pharmaceutical field.Type: GrantFiled: November 16, 1998Date of Patent: April 1, 2003Assignee: Bristol-Myers Squibb CompanyInventor: Ramesh N. Patel
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Patent number: 6515151Abstract: Methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Compounds prepared by the methods of the present invention are also disclosed.Type: GrantFiled: June 13, 2000Date of Patent: February 4, 2003Assignee: Bristol-Myers Squibb CompanyInventors: Michael A. Poss, Jerome L. Moniot, Ivan D. Trifunovich, David J. Kucera, John K. Thottahil, Shu-Hui Chen, Jianmei Wei
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Patent number: 6433198Abstract: An enzymatic hydroxylation method for the preparation of compounds useful as intermediates in the preparation of taxanes such as 6-&agr;-hydroxy-7-deoxypaclitaxel, wherein one or more C-6 hydrogen-bearing taxanes are contacted with an enzyme or microorganism capable of hydroxylating said C-6 carbon to give C-6 hydroxyl-bearing taxane.Type: GrantFiled: July 13, 2000Date of Patent: August 13, 2002Assignee: Bristol-Myers Squibb CompanyInventors: Ronald L. Hanson, Ramesh N. Patel
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Patent number: 6407299Abstract: The present invention is a two-component catalyst system comprising (a) an alkyl magnesium (MgR2) component and (b) a Lewis acid component. The catalyst system is used for catalyzing the oligomerization and polymerization of ethylene and/or &agr;-olefins to form homopolymers and copolymers. The products range from highly linear, high molecular weight, solid polymers to highly branched, lower molecular weight oils.Type: GrantFiled: June 2, 2000Date of Patent: June 18, 2002Assignees: ExxonMobile Research and Engineering Company, The Pennsylvania State Research FoundationInventors: Ayusman Sen, Jang Sub Kim
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Patent number: 6344490Abstract: A removable filter for separating and filtering slurry liquid from solid particles includes one or more filter sections connected by a filtrate conduit. Each section comprises a plurality of vertical, hollow, sintered metal filter elements horizontally arranged across a manifold connected to a hollow filtrate conduit. The sections are vertically stacked and connected by the conduit(s) to form the filter which is removably secured in the slurry by means which permit it to be removed vertically up and out of the top of the reactor. This filter has a high surface area to volume ratio and is useful for removing the liquid hydrocarbon products from a slurry hydrocarbon synthesis reactor and can easily be replaced without having to drain out the slurry.Type: GrantFiled: January 22, 1999Date of Patent: February 5, 2002Assignee: Exxon Research and Engineering CompanyInventors: Charles W. DeGeorge, Barry J. Thompson
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Patent number: 6262225Abstract: The invention is related to an olefin-carbon monoxide-vinyl monomer terpolymer composition which is derived from an olefin feed and a synthesis gas feed and at least one vinyl monomer feed. The invention is also related to a method for preparing olefin-carbon monoxide-vinyl monomer terpolymers by heating an olefin feed, a synthesis gas feed and at least one vinyl monomer feed in the presence of a free radical polymerization initiator. More particularly, the synthesis gas feed comprises predominantly carbon monoxide and hydrogen. The terpolymers of the invention are useful as polyvinyl chloride plasticizers.Type: GrantFiled: July 18, 2000Date of Patent: July 17, 2001Assignee: ExxonMobil Research and Engineering CompanyInventors: Abhimanyu O. Patil, Manika Varma-Nair
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Patent number: 6191218Abstract: The invention is directed towards a method for improving hot tack in blown polyethylene films. Accordingly, a nucleating agent and polyethylene are combined to form a melt from which the film is blown. The method comprises forming a melt of polyethylene and a nucleating agent selected from the group consisting of dibenzylidene sorbitol, paramethyldibenzylidene sorbitol, dimethyldibenzylidene sorbitol, ethylene copolymers containing grafted maleic anhydride, ethylene copolymers containing grafted acrylic acid, and mixtures thereof. Polyethylene films having increased hot tack can be blown therefrom.Type: GrantFiled: July 14, 1998Date of Patent: February 20, 2001Assignee: Exxon Research and Engineering CompanyInventor: Arnold Lustiger
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Patent number: 6180788Abstract: The invention is directed towards a metal complex having the formula LMX1X2. L is a bidentate nitrogen-containing ligand with more than 2 nitrogens. M is copper, silver, or gold. X1 and X2 are independently selected from the group consisting of halogens, hydride, triflate, acetate, trifluoroacetate, perfluorotetraphenylborate, tetrafluoroborate, C1 through C12 alkyl, C1 through C12 alkoxy, C3 through C12 cycloalkyl, C3 through C12 cycloalkoxy, aryl, and any other moiety into which a monomer can insert. Such metal complexes have a tetrahedral or pseudo-tetrahedral structure.Type: GrantFiled: October 29, 1999Date of Patent: January 30, 2001Assignee: Exxon Research and Engineering CompanyInventor: Robert T Stibrany
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Patent number: 6156872Abstract: The invention is related to non-linear, paraffin-soluble olefin/carbon monoxide and olefin/acetylene/carbon monoxide copolymers. The invention is also related to a method for preparing olefin/carbon monoxide copolymers by heating a feed of at least one olefin, carbon monoxide, carbon dioxide, hydrogen, and methane in the presence of a free radical polymerization initiator. More particularly, the feed comprises at least one olefin, the total olefin amount ranging from about 5 to about 40 mole %, carbon monoxide in an amount ranging from about 1 to about 40 mole %, hydrogen in an amount ranging from about 4 to about 55 mole %, carbon dioxide in an amount ranging from about 3 to about 10 mole %, and methane in an amount ranging from about 4 to about 85 mole %. The feed may also include acetylene in an amount ranging up to about mole %.Type: GrantFiled: January 19, 1999Date of Patent: December 5, 2000Assignee: Exxon Research and Engineering Co.Inventors: Abhimanyu O. Patil, Donald N. Schulz, Raymond A. Cook, Michael G. Matturro
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Patent number: 6114443Abstract: The present invention is based on the discovery that diblock copolymers of ethylene and an atactic alpha-olefin that are prepared in the presence of a catalyst system comprising at least one metallocene compound and a non-coordinating anion are especially useful as compatibilizers with blends of polyethylene and isotactic poly-alpha-olefin homopolymers.Type: GrantFiled: June 23, 1997Date of Patent: September 5, 2000Assignee: Exxon Research and Engineering Co.Inventors: David John Lohse, Henry Wu-Hsiang Yang
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Patent number: 6037297Abstract: The invention is directed towards a metal complex having the formula LMX.sub.1 X.sub.2. L is a bidentate nitrogen-containing ligand with more than two nitrogen atoms. M is copper, silver, or gold. X.sub.1 and X.sub.2 are independently selected from the group consisting of halogens, C.sub.1 through C.sub.12 straight chain, branched, or cycloalkyl or aryl, C.sub.1 through C.sub.12 straight chain, branched, or cycloalkoxy, hydride, triflate, trifluoroacetate, trisperfluorotetraphenylborate, and tetrafluoroborate. Such metal complexes have a tetrahedral or pseudo-tetrahedral structure. The invention relates to a catalyst composition of the reaction product of the metal complex and an activating cocatalyst. The invention is also directed towards a method for forming polymers and copolymers using such catalyst compositions, especially copolymers having segments formed from olefinic monomers and monomers having at least one hydrocarbyl polar functional group.Type: GrantFiled: December 15, 1998Date of Patent: March 14, 2000Assignee: Exxon Research and Engineering Co.Inventors: Robert T. Stibrany, Donald N. Schulz, Smita Kacker, Abhimanyu O. Patil
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Patent number: 6015929Abstract: This invention is directed toward a method for inhibiting the formation (nucleation, growth and agglomeration) of clathrate hydrates. The method comprises adding into a mixture of hydrate forming substituents and water, an effective amount of a hydrate anti-agglomerate selected from the group consisting of anionic, cationic, non-ionic and zwitterionic hydrate anti-agglomerate. The hydrate anti-agglomerant has a polar head group and a nonpolar tail group said nonpolar tail group not exceeding 11 carbon atoms in the longest carbon chain.Type: GrantFiled: February 13, 1998Date of Patent: January 18, 2000Assignee: Exxon Research and Engineering Co.Inventors: Manese Rabeony, Dennis George Peiffer, Christine Ann Costello, Karla Schall Colle, Pamela J Wright, Larry Dalton Talley