Patents Represented by Attorney Kent Barta
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Patent number: 7544293Abstract: A unique valve assembly for simulated bed moving chromatography employs a combination of pressure compatible sealable materials that permit minimal frictional interaction between moving parts, ensures alignment of parts, and provides a method for conducting SMB countercurrent chromatography on a small scale, in which purity and separation efficiency are enhanced. Machine designs are disclosed which embody the SMB concepts. Finally, a quick disconnect connector and adaptor is provided for mounting chromatographic columns in an SMB device. Demonstration of this system in a fructose-glucose isomer separation with purity-recovery trade-off for this device is also presented.Type: GrantFiled: September 26, 2005Date of Patent: June 9, 2009Assignee: SEMBA Inc.Inventors: Anil Rajaram Oroskar, Saurabh Paresh Parikh, Asha Anil Oroskar, Kenneth U. Johnson, Anthony Joseph Escarcega
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Patent number: 7449598Abstract: The present invention relates to methods for preparing lithium valproate and administering this compound to a subject in need of treatment with lithium and/or valproate. Pharmaceutical compositions are also provided that are useful therapies for the treatment of neurological, immunological, and viral-mediated disorders in warm-blooded mammals.Type: GrantFiled: March 19, 2007Date of Patent: November 11, 2008Assignee: BioLink Life Sciences, Inc.Inventors: Navdeep B. Malkar, Deanna Jean Nelson, Walter C. Holberg, III
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Patent number: 5506105Abstract: In an in situ hybridization assay, cells are fixed under conditions which preserve essential morphology, followed by transcription-based nucleic acid amplification of intracellular mRNA targets. The amplified targets are visualized by hybridizing labelled probes to the target sequences. The assay thereby provides a convenient method for detecting specific gene expression associated with morphologic characteristics of diagnostic significance.Type: GrantFiled: March 22, 1994Date of Patent: April 9, 1996Assignee: Dade International Inc.Inventor: Paul V. Haydock
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Patent number: 5395688Abstract: This invention provides a novel process of producing magnetically responsive fluorescent polymer particles comprising polymeric core particles coated evenly with a layer of polymer containing magnetically responsive metal oxide. A wide variety of polymeric particles with sizes ranging from 1 to 100 microns can be used a core particles and transformed into magnetically responsive polymer particles. The surface of these magnetically responsive polymer particles can be coated further with another layer of functionalized polymer. These magnetically responsive fluorescent polymer particles can be used for passive or covalent coupling of biological material such as antigens, antibodies, enzymes or DNA/RNA hybridization and used as solid phase for various types of immunoassays, DNA/RNA hybridization probes assays, affinity purification, cell separation and other medical, diagnostic, and industrial applications.Type: GrantFiled: August 30, 1993Date of Patent: March 7, 1995Assignee: Baxter Diagnostics Inc.Inventors: Chao-Huei J. Wang, Dinesh Q. Shah
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Patent number: 5352773Abstract: The present invention relates to a stable hemoglobin based composition having sufficiently low levels of methemoglobin to effectively function as an oxygen carrying solution upon administration to a patient made by the process comprising: a) adding an oxygenated or deoxygenated form of said blood substitute to an oxygen impermeable package, and b) storing said container at from between 5.degree. C. to 45.degree. C. for sufficient time to permit the autoreduction of methemoglobin. The stable hemoglobin based composition includes hemoglobin, modified hemoglobin and/or encapsulated hemoglobin. To effectively function as an oxygen carrying solution upon administration to a patient, the stable hemoglobin based solution cannot have greater than about 50% of said hemoglobin based solution in the methemoglobin form but, preferably no more than about 15%. The invention further relates to a method to store a stable oxygen carrying solution according to the above discussed process.Type: GrantFiled: October 16, 1992Date of Patent: October 4, 1994Assignee: Baxter International Inc.Inventors: Richard L. Kandler, John C. Spicuzza
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Patent number: 5334706Abstract: This invention provides a method to therapeutically increase perfusion in a mammal comprising administering stroma-free hemoglobin at a dose ranging from the least amount effective to increase perfusion, up to a dose of about 2500 mg per kilogram of body weight.Type: GrantFiled: January 30, 1992Date of Patent: August 2, 1994Assignee: Baxter InternationalInventor: Robert J. Przybelski
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Patent number: 5310878Abstract: A biosynthetic cerebrospinal fluid control and method of use. Additionally, this invention relates to the isolation and purification of stable liquid human prealbumin, a component in the biosynthetic cerebrospinal fluid control.Type: GrantFiled: October 23, 1992Date of Patent: May 10, 1994Assignee: Baxter Diagnostics Inc.Inventor: Kathryn D. Herring
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Patent number: 5283079Abstract: This invention provides a novel process of producing magnetically responsive fluorescent polymer particles comprising polymeric core particles coated evenly with a layer of polymer containing magnetically responsive metal oxide. A wide variety of polymeric particles with sizes ranging from 1 to 100 microns can be used a core particles and transformed into magnetically responsive polymer particles. The surface of these magnetically responsive polymer particles can be coated further with another layer of functionalized polymer. These magnetically responsive fluorescent polymer particles can be used for passive or covalent coupling of biological material such as antigens, antibodies, enzymes or DNA/RNA hybridization and used as solid phase for various types of immunoassays, DNA/RNA hybridization probes assays, affinity purification, cell separation and other medical, diagnostic, and industrial applications.Type: GrantFiled: December 14, 1989Date of Patent: February 1, 1994Assignee: Baxter Diagnostics Inc.Inventors: Chao-Huei J. Wang, Dinesh O. Shah
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Patent number: 5266462Abstract: Methods are provided for measuring the procoagulant activity of platelets in blood by means of a chromogenic assay which is specific for procoagulant phospholipids. These methods include the determination of the resting activity and/or excitability of platelets, which determines the threshold at which activating clotting factors (circulating in blood) are dangerous. Also methods are provided for screening drugs for their potential inhibitory effect on the activation of platelets.Type: GrantFiled: June 3, 1992Date of Patent: November 30, 1993Assignee: Baxter Diagnostics Inc.Inventors: Hendrik C. Hemker, Robert J. Wagenvoord
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Patent number: 5245038Abstract: A class of fluorescent rare earth chelates and the ligands upon which they are based whose molecular structure incorporates a plurality of substituted arylpyridine diacid units attached to a central template structure is disclosed. These ligands function as efficient energy transfer groups in fluorescent tagging reagents and tracers.Type: GrantFiled: March 27, 1991Date of Patent: September 14, 1993Assignee: Baxter Diagnostics Inc.Inventors: Ron L. Hale, Dennis W. Solas
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Patent number: 5242806Abstract: A method and apparatus for assaying the sensitivity of biopsied tumor cells to chemotherapeutic agents using a predetermined amount of chemotherapeutic agent in an easily deliverable form is disclosed and claimed.Type: GrantFiled: May 15, 1992Date of Patent: September 7, 1993Assignee: Baxter Diagnostics Inc.Inventors: Yu P. Yen-Maguire, Tom Cox, Fred Lewis
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Patent number: 5173434Abstract: A process to determine the concentration of any substance in a colorimetric, turbidimetric or nephelometric reaction using a fluorometric detector to measure fluorescence intensity. In particular, a change in color can be monitored by observing the measurement of fluorescence intensity of a fluorophore in an inert matrix. The absorption spectrum of the chromophore may overlap the excitation and/or emission spectrum of the fluorophore, thereby allowing the change in fluorescence to be related to the intensity of color in the reaction and thus related to the quantity of the substance of interest.Type: GrantFiled: November 5, 1990Date of Patent: December 22, 1992Assignee: Baxter Diagnostics Inc.Inventors: Roger J. Morris, Shoshana Bascomb, Carolyn S. Olson
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Patent number: 5116989Abstract: A class of fluorescent rare earth chelates and the ligands upon which they are based whose molecular structure incorporates a plurality of substituted arylpyridine diacid units attached to a central template structure is disclosed. These ligands function as efficient energy transfer groups in fluorescent tagging reagents and tracers.Type: GrantFiled: May 30, 1989Date of Patent: May 26, 1992Assignee: Baxter Diagnostics Inc.Inventors: Ron L. Hale, Dennis W. Solas
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Patent number: 5106957Abstract: A class of fluorescent rare earth chelates and the ligands upon which they are based whose molecular structure incorporates a plurality of substituted arylpyridine diacid units attached to a central template structure is disclosed. These ligands function as efficient energy transfer groups in fluorescent tagging reagents and tracers.Type: GrantFiled: March 27, 1991Date of Patent: April 21, 1992Assignee: Baxter Diagnostics Inc.Inventors: Ron L. Hale, Dennis W. Solas
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Patent number: 5091206Abstract: This invention provides a novel process of producing magnetically responsive polymer particles comprising polymeric core particles coated evenly with a layer of polymer containing magnetically responsive metal oxide. A wide variety of polymeric particles with sizes ranging from 1 to 100 microns can be used a core particles and transformed into magnetically responsive polymer particles. The surface of these magnetically responsive polymer particles can be coated further with another layer of functionalized polymer. These magnetically responsive polymer particles can be used for passive or covalent coupling of biological material such as antigens, antibodies, enzymes of DNA/RNA hybridization and used as solid phase for various types of immunoassays, DNA/RNA hybridization probes assays, affinity purification, cell separation and other medical, diagnostic, and industrial applications.Type: GrantFiled: May 30, 1989Date of Patent: February 25, 1992Assignee: Baxter Diagnostics Inc.Inventors: Chao-Huei Wang, Dinesh O. Shah
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Patent number: 5055578Abstract: A class of fluorescent rare earth chelates and the ligands upon which they are based whose molecular structure incorporates a plurality of substituted arylpyridine diacid units attached to a central template structure is disclosed. These ligands function as efficient energy transfer groups in fluorescent tagging reagents and tracers.Type: GrantFiled: November 5, 1990Date of Patent: October 8, 1991Assignee: Baxter Diagnostics Inc.Inventors: Ron L. Hale, Dennis W. Solas