Abstract: Modified neurotoxins that contain protease cleavage sites susceptible uniquely to proteases present in certain tissues are described. The toxins can be selectively activated by proteases in muscle or selectively inactivated by proteases in blood.
Type:
Grant
Filed:
September 18, 2008
Date of Patent:
November 13, 2012
Assignee:
Allergan, Inc.
Inventors:
Wei-Jen Lin, Kei Roger Aoki, Lance E. Steward
Abstract: The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to botulinum toxin therapy in an individual, methods of treating immunoresistance to botulinum toxin therapy in an individual, methods of reducing anti-botulinum toxin antibodies in an individual and methods of inducing a BoNT/B immune response an individual.
Type:
Grant
Filed:
May 30, 2007
Date of Patent:
December 21, 2010
Assignees:
Allergan, Inc., Baylor College of Medicine
Abstract: Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.
Abstract: Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.
Abstract: A method of generating a mailer on demand by receiving data for an envelope and a matching document in a computer, placing data for the envelope and the document in a production queue, generating the envelope using the data, generating the document using the data, automatically verifying the correct generation and sequence of the envelope, automatically verifying the correct generation and sequence of the document, removing any envelope or document if the verification process returns a false condition for correct generation or sequence in order to maintain order integrity of the production queue and automatically regenerating the incorrectly generated or sequenced piece and all other corresponding piece(s) of the mailer, and matching a verified envelope with a matching verified document and creating the mailer.