Patents Represented by Attorney, Agent or Law Firm Kerri Pollard Schray
  • Guanidinomethyl cyclohexane carboxylic acid ester derivatives
    Patent number: 6284791
    Abstract: A compound represented by general formula (I-2) or a pharmaceutically acceptable acid-addition salt thereof, useful as an anti-microbial against Helicobacter pylori and as a medicinal composition for treating Helicobacter pylori infection, wherein Ar represents phenyl, biphenyl or naphthyl each having a at least one substituent selected from the group consisting of halogen, cyano, nitro, carboxy, C1-C18 alkyl, C1-C18 alkoxy, C3-C18 cycloalkyl, C7-C18 aralkyl, C8-C18 arylalkenyl, C7-C18 aralkyloxy, optionally substituted phenoxy, optionally substituted C2-C19 alkoxycarbonyl, and optionally substituted C8-C19 aralkyloxycarbonyl, provided the case where Ar represents phenyl substituted by halogen, cyano, nitro, carboxy, C1-C18 alkyl, optionally substituted C2-C19 alkoxycarbonyl or C8-C19 aralkyloxycarbonyl is expected.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: September 4, 2001
    Assignee: Teikoku Chemical Industries Co., Ltd.
    Inventors: Osamu Kamoda, Hiromichi Fujiwara, Toshiharu Yanagi
  • Methods for treatment of conditions associated with lactosylceramide
    Patent number: 6228889
    Abstract: The present invention includes methods for treatment and prophylaxis of diseases, post-surgical disorders and bacterial infections associated with lactosylceramide. The methods generally provide for administration for a mammal, particularly a human, of a therapeutically effective amount of a compound that inhibits UDPGal:GlcCer&bgr;1−>4 galactosylceramide (GalT-2). In vitro and in vivo assays for detecting compounds with therapeutic capacity to modulate GalT-2 are also provided.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: May 8, 2001
    Assignee: Johns Hopkins University
    Inventor: Subroto Chatterjee
  • Anti-pathogen system and methods of use thereof
    Patent number: 6221355
    Abstract: The present invention provides an anti-pathogen system comprising one or more fusion proteins that includes a transduction domain and a cytotoxic domain. The cytotoxic domain is specifically activated by a pathogen infection. The anti-pathogen system effectively kills or injures cells infected by one or a combination of different pathogens. Further provided are protein transduction domains that provide enhanced transduction efficiency.
    Type: Grant
    Filed: December 10, 1998
    Date of Patent: April 24, 2001
    Assignee: Washington University
    Inventor: Steven F. Dowdy
  • Methods for treatment of disorders of cardiac contractility
    Patent number: 6191136
    Abstract: The present invention relates to methods for modulating calcium sensitivity of cardiac muscle. In preferred aspects, the invention provides methods for enhancing myocardial contractility and cardiac performance, and methods for treatment of heart failure and other disorders associated with cardiac contractility by administration of one or more xanthine oxidase inhibitor compounds.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: February 20, 2001
    Assignee: Johns Hopkins University
    Inventor: Eduardo Marban