Patents Represented by Attorney, Agent or Law Firm Kimberly J. Prior
  • Naphthalenyl piperidines as renin inhibitors
    Patent number: 6673931
    Abstract: Piperidine derivatives, their manufacture and use as medicaments is described. The compounds are useful for treating diseases associated with restenosis, glaucoma, cardiac infarct, high blood pressure and end organ damage, e.g. cardiac insufficiency and kidney insufficiency.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: January 6, 2004
    Assignee: Hoffman-La Roche Inc.
    Inventors: Volker Breu, Hans-Peter Märki, Eric Vieira, Wolfgang Wostl
  • Imidazole derivatives
    Patent number: 6667335
    Abstract: Novel imidazole derivatives are disclosed. These compounds have a good affinity to the NMDA (N-methyl-D-aspartate)-receptor subtype selective blockers, which have a key function in modulating neuronal activity and plasticity which makes them key players in mediating processes underlying development of CNS as well as learning and memory formation. These compounds are useful in the control or treatment of diseases mediated by this receptor.
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: December 23, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alexander Alanine, Bernd Buettelmann, Marie-Paule Heitz Neidhart, Georg Jaeschke, Emmanuel Pinard, Rene Wyler
  • Pyridine amido derivatives
    Patent number: 6667327
    Abstract: Disclosed are pyridine amido derivatives of the formula wherein X, Y, and R1 to R6 are as defined herein. These compounds are selective MAO-B inhibitors and are useful in treating diseases such as, for example, Alzheimer's and senile dementia. Also disclosed are pharmaceutical compositions containing such compounds and a method of preparing such compounds.
    Type: Grant
    Filed: January 14, 2003
    Date of Patent: December 23, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrea Cesura, Rosa Maria Rodriguez Sarmiento, Andrew William Thomas, Rene Wyler
  • Di-or triaza-spiro [4,5] decane derivatives
    Patent number: 6642247
    Abstract: The present invention relates to compounds of the general formula wherein R1 is C6-10-cycloalkyl, optionally substituted by lower alkyl or —C(O)O-lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; decahydro-azulen-2-yl; bicyclo[6.2.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: November 4, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Geo Adam, Andrea Cesura, François Jenck, Sabine Kolczewski, Stephan Röver, Jürgen Wichmann
  • Substituted phenyl-piperidine methanone compounds
    Patent number: 6642226
    Abstract: The invention relates to compounds of the formula wherein R1 is optionally substituted phenyl, morpholinyl, piperazinyl, pyrrolidinyl, piperidinyl or is thiomorpholinyl, 1-oxo-thiomorpholinyl or 1,1-dioxothiomorpholinyl. These compounds have a good affinity to the NK-1 receptor and they are therefore suitable in the control or treatment of diseases, related to this receptor.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: November 4, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Sabine Kolczewski, Stephan Roever, Patrick Schnider
  • Process for the preparation of ethanesul fonyl-piperidine derivatives
    Patent number: 6605723
    Abstract: The present invention relates to a new process for the preparation of compounds of the formulae and their pharmaceutically acceptable acid addition salts, which are NMDA (N-methyl-D-aspartate)-receptor-subtype selective blockers.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: August 12, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Yvo Crameri, Michelangelo Scalone, Pius Waldmeier, Ulrich Widmer
  • 7-Morpholin-4yl-benzothiazole amide derivatives
    Patent number: 6596718
    Abstract: A compound of the formula A compound of formula I has a good affinity to the A2A receptor and is useful for the treatment of diseases mediated by this receptor.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: July 22, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alexander Flohr, Roland Jakob-Roetne, Norcross David Roger, Claus Riemer
  • NK-1 receptor active amine oxide prodrugs
    Patent number: 6593472
    Abstract: Compounds of the invention are amine oxide prodrugs showing activity on the NK1 receptor.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: July 15, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Torsten Hoffmann, Sonia Maria Poli, Patrick Schnider, Andrew Sleight
  • Adenosine receptor ligands and their use in the treatment of disease
    Patent number: 6586441
    Abstract: The invention relates to cyclic heteroaromatic compounds, containing at least one nitrogen atom, and to their use in the manufacture of medicaments for the treatment of diseases, related to adenosine receptor modulators, such as Alzheimer's disease, Parkinson's disease, neuroprotection, schizophrenia, anxiety, pain, respiration deficits, depression, asthma, allergic responses, hypoxia, ischaemia, seizure, substance abuse, sedation and they may be active as muscle relaxants, antipsychotics, anti epileptics, anticonvulsants and cardiaprotective agents.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: July 1, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Edilio Maurizio Borroni, Gerda Huber-Trottmann, Gavin John Kilpatrick, Roger David Norcross
  • Heteroaromatic substituted amides with antagonistic activity to neurokinin 1 receptors
    Patent number: 6576762
    Abstract: The present invention is a heteroaromatic substituted amide showing antagonist activity to neurokinin 1 (NK-1, substance P) receptors.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: June 10, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Torsten Hoffmann, Patrick Schnider, Heinz Stadler