Abstract: Isolated nucleic acid encoding human smooth muscle cell-derived migration factor, protein obtainable from the nucleic acid, recombinant host cells transformed with the nucleic acid and use of the protein and nucleic acid sequence are disclosed.
Type:
Grant
Filed:
April 23, 1997
Date of Patent:
June 29, 1999
Inventors:
Mark Robert Hurle, Peter Colon McDonnell, Dean Edward McNulty, Craig Alan Rosen, Ivo Rogulia Siemens, Peter Ronald Young, Tian-Li Yue
Abstract: Isolated nucleic acid encoding a growth factor receptor binding protein-insulin receptor isoform, protein obtainable from the nucleic acid, recombinant host cells transformed with the nucleic acid and use of the protein and nucleic acid sequence are disclosed.
Type:
Grant
Filed:
July 9, 1997
Date of Patent:
November 24, 1998
Inventors:
Damien J. Dunnington, James D. Frantz, Steven E. Shoelson
Abstract: This invention relates to a novel protein capable of inducing an immune response protective against human malarial infection caused by Plasmodium falciparum, and to the cloning and expression of a gene encoding the said protein. The invention further relates to novel vaccines comprising the said protein and to their use in the vaccination of humans at risk from malaria.
Type:
Grant
Filed:
May 25, 1995
Date of Patent:
August 25, 1998
Assignee:
University of Nijmegan
Inventors:
Johannes Gerardus Ghislain Schoenmakers, Rudolph Nicholaas Hendrik Konings, Inge Irma Maria Dominique Moelans
Abstract: A DNA encoding a 16 kD protein capable of inducing an immune response protective against human malarial infection caused by Plasmodium falciparum, and to the cloning and expression of a gene encoding the said protein. The invention further relates to novel vaccines comprising the said protein and to their use in the vaccination of humans at risk from malaria.
Type:
Grant
Filed:
May 25, 1995
Date of Patent:
August 25, 1998
Assignee:
University of Nijmegan
Inventors:
Johannes Geradus Ghislain Schoenmakers, Rudolph Nicolaas Hendrik Konings, Inge Irma Maria Dominique Moelans
Abstract: Isolated nucleic acids encoding human lymphoid-specific transcription factors NERF-1 and NERF-2, proteins obtainable from the nucleic acids, recombinant host cells transformed with the nucleic acids and use of the proteins and nucleic acid sequences are dislcosed.
Type:
Grant
Filed:
January 3, 1995
Date of Patent:
February 24, 1998
Assignee:
Human Genome Sciences, Inc.
Inventors:
Towia Aron Libermann, Joerg Peter Oettgen, Charles A. Kunsch
Abstract: A method for identifying new classes of chemical entities which dissociate specific protein-protein complexes. Antibodies are employed to specifically quantitate target protein-protein complexes.
Abstract: An computer-based iterative method for analyzing partial gene sequences. Putative gene assemblies are built from partial gene sequences by the method. A series of pre-processing steps prior to assembly allows efficient and accurate assembly of large amounts of partial gene sequences.
Type:
Grant
Filed:
June 2, 1995
Date of Patent:
April 8, 1997
Assignee:
SmithKline Beecham Corporation
Inventors:
Robert K. Stodola, Frank L. Tobin, Arthur L. Williams, Jr.