Abstract: A method for treating a cancer, by determining a patient to have an ECOG (Eastern Cooperative Oncology Group) score of 0 or 1 and selecting that patient for treatment, and administering to the patient an effective amount of an immunomodulating composition comprising small molecular weight components of less than 3000 daltons, and having the following properties: (i) is extracted from bile of animals; (ii) is capable of stimulating monocytes and/or macrophages; (iii) is capable of modulating tumor necrosis factor production and/or release; (iv) contains no measurable level of IL-1?, IL-1?, TNF, IL-6, IL-8, IL-4, GM-CSF or IFN-?; (v) is not cytotoxic to human peripheral blood mononuclear cells; and (vi) is not an endotoxin. A method of increasing the survival rate of a cancer patient.

Abstract: The application describes an assay for the identification of small molecule modulators of integrin CD11b/CD18 and small molecules capable of modulating activity of this receptor. For example, one such compound useful as an agonist of integrin CD11b/CD18 is the compound of Formula (I): Such compounds may be used in certain embodiments for treating a disease or condition selected from inflammation, immune-related disorders, cancer, ischemia-reperfusion injury, stroke, neointimal thickening associated with vascular injury, bullous pemphigoid, neonatal obstructive nephropathy, and cardiovascular disease, or in other embodiments for the treatment of a disease or condition selected from immune deficiency, acquired immune deficiency syndrome (AIDS), myeloperoxidase deficiency, Wiskott-Aldrich syndrome, chronic granulomatous disease, hyper-IgM syndromes, leukocyte adhesion deficiency, Chediak-Higashi syndrome, and severe combined immunodeficiency.

Abstract: A method for treating a cancer, by determining a patient to have an ECOG (Eastern Cooperative Oncology Group) score of 0 or 1 and selecting that patient for treatment, and administering to the patient an effective amount of an immunomodulating composition comprising small molecular weight components of less than 3000 daltons, and having the following properties: (i) is extracted from bile of animals; (ii) is capable of stimulating monocytes and/or macrophages; (iii) is capable of modulating tumor necrosis factor production and/or release; (iv) contains no measurable level of IL-1?, IL-1?, TNF, IL-6, IL-8, IL-4, GM-CSF or IFN-?; (v) is not cytotoxic to human peripheral blood mononuclear cells; and (vi) is not an endotoxin.

Abstract: A method of prophylactic and/or therapeutic treatment of a mammal for a disease that is caused by a Ljungan virus infection, such as Myocarditis, Cardiomyopathia, Guillain Barre Syndrome, and Diabetes Mellitus, Multiple Sclerosis, Chronic Fatigue Syndrome, Myasthenia Gravis, Amyotrophic Lateral Sclerosis, Dermatomyositis, Polymyositis, Spontaneous Abortion, Intrauterine Death, Preeclampsia, Sudden infant Death Syndrome, Bell's (facial) paralysis, Addison's disease, and Pernicious anemia, is described. An antiviral compound effective against a Ljungan virus, such as a compound effective against a picornavirus, e.g. Pleconaril or a derivative thereof, is used for the preparation of a medicament for the treatment of a disease in a mammal that is caused by a Ljungan virus infection, to eliminate or inhibit proliferation of the virus in the mammal and at the same time prevent and/or treat the disease in the mammal.

Abstract: The present invention relates to a frame for attaching to a patient. The present invention also relates to a stereoguide and a member for attaching to a patient. The present invention also relates to a method for manufacturing the frame, member and stereoguide of the present invention. The frame, member and stereoguide are constructed from a composite material comprising a matrix material and electromagnetically inert fibers.

Abstract: According to the present invention, there is provided a sports training apparatus for accurately simulating the football maneuver known as the ‘cut-block.’ The present invention comprises a track, a rolling cart fitted to the track, an upright blocking pillar connected to the cart, and a triggering system for lowering and raising the blocking pillar at specified intervals in order to simulate the cut-block maneuver. The present invention additionally includes a stopping mechanism for stopping the movement of the cart.

Abstract: A spinal implant assembly includes a housing for containing a bearing member therein and seating within an intervertebral space and a bearing member disposed within the housing for enabling disc-like movement between vertebrae defining the intervertebral space. The combination of the housing and bearing member provide a distracting mechanism disposed within the housing halves 12, 14 for distracting the housing halves 12, 14 from a first condition in which the housing halves 12, 14 are floatable into the intervertebral space to a second condition in which the housing halves 12, 14 are distracted to fixedly engage the opposing vertebral services defining the intervertebral space.

Abstract: The present invention is a load sharing intervertebral fusion device that allows for reconstruction of the proper disc space between two vertebral bodies while allowing bone material packed within the fusion device to share loading and stress for enhanced healing. The device includes two sections, an upper and lower section, separated by a bioresorbable spacer. The upper section slides relative to the lower section with the bioresorbable material being placed in load therebetween. The upper section and lower sections are effectively held apart, creating an initial fixed spacer for implantation of the intervertebral disc space. Openings in the implant construct allow for bone graft and bone substitutes to be placed within the implant to allow for fusion through the implant construct. After implantation and over a period of time based on bone resorbtion and remodeling, the spacer resorbs, thereby maintaining load on the bone graft material.

Abstract: An electronic data analysis, storage, and retrievable system includes a verification capability for verifying the integrity of the system's operational health. An operation monitoring mechanism continuously monitors the system's operation. A collection mechanism contains relevant system data. The system further includes a storage ability for archiving system data. A media verification mechanism verifies the integrity and authenticity of storage media. Finally, a data analysis mechanism analyzes and compares archived system information.

Abstract: A nano-sensor including a substrate including pores formed thereon and a detecting mechanism for detecting changes in capacitance due to the presence of a substance. A method of measuring humidity by sampling air with the nano-sensor, detecting changes in capacitance, and determining the relative humidity of air. A method of detecting the presence of a substance by taking a sample with the nano-sensor, detecting changes in capacitance, and determining the presence of a substance. A method of making the nano-sensor by forming nano-pores on a substrate, and forming, on the surface of the substrate, a detecting mechanism for detecting changes in capacitance due to the presence of a substance.

Abstract: A reconfigurable modular retractor system including a set of interchangeable body modules, the body modules including mechanisms for forming retractors and slot mechanisms for connecting blades, and blades including locking mechanisms for locking inside the slot mechanisms. A method of using the retractor system by forming a retractor by using at least one body module, attaching blades to the body module, inserting the retractor into a surgical area, retracting tissue, removing retraction from the tissue, and removing the retractor.

Abstract: A concave cell for the collection of radiated light including a body with a concave surface and an unmodified flat surface opposite thereto, and a reflective surface coupled to the body across from the concave surface, said reflective surface including an opening and a photo detector operatively coupled thereto. A method of collecting light by reflecting light inside the concave cell, striking the light at the concave surface, scattering the light at the concave surface, and registering the scattered light with the photo detector. A method of increasing uniformity of light registered in a photo detector. A method of making a concave cell.

Abstract: A power flow control system including an integrated circuit having a mechanism for determining an amount of energy storage required for power source devices and a mechanism for controlling power flow delivery between the power source devices. A power flow control system also including more than one power source device in electrical connection with the power flow control system. An efficient hybrid vehicle, including the power flow control system integrated in the hybrid vehicle, and more than one power source device in electrical connection with the power flow control system and operatively connected to the hybrid vehicle. A method of controlling power flow in a vehicle, including the steps of determining the amount of energy storage required for power source devices, and controlling power flow delivery between the power source devices. Power flow control systems and methods of using for fuel cell and battery combinations and battery and super-capacitor combinations.

Abstract: A self-tuning vibration absorber including a carrier rod assembly having operatively connected thereto a mounting mechanism for mounting the carrier rod assembly to a primary system and a hollow shafted motorized tuning mechanism for tuning a phase difference between vibration of the primary system and vibration of the carrier rod assembly to 90 degrees, the carrier rod assembly further including a detecting mechanism for detecting the vibration of the primary system and the vibration of the carrier rod assembly, and a controller in electrical connection with the detecting mechanism and the tuning means for controlling the tuning mechanism based on the vibration of the primary system and the vibration of the carrier rod assembly detected. A method of vibration dampening, a method of controlling a self-tuning vibration absorber, and a method of reducing hunting motion in railcars.

Abstract: According to the present invention, there is provided a system and method for the collection, capture, processing, storage, and tracking of data for both electronic clinical trial and electronic source health records for purposes, based upon a single data collection instance. Upon the collection of data at a clinical trial site, the data are transmitted to a central server where it is captured as an electronic source document(s) in human readable format. The system then transmits the captured electronic source document to a trusted third-party's electronic document repository. Then, the system uses the same captured data to populate the clinical trial's electronic data capture database. The system incorporates security and encryption features to ensure that privacy information requirements are not violated. In the preferred embodiment, the electronic data capture provider for a clinical trial has no control over the server of the trusted third-party vendor, complying with regulatory requirements.

Abstract: An omni directional mobility device made of a spherical device that is capable of omni directional movement. An omni directional vehicle including a vehicle and at least one omni directional mobility device made of a spherical device for enabling omni directional movement.

Abstract: A method of increasing immunological effect in a patient by administering an effective amount of a primary cell derived biologic to the patient, inducing immune production, blocking immune destruction, and increasing immunological effect in the patient. Methods of treating an immune target, treating a tumor, immune prophylaxis, and preventing tumor escape.

Abstract: A biosensor for use in detecting the presence of diseases, the biosensor comprising a detector for detecting a presence of at least one marker indicative of a specific disease. A method of determining efficacy of a pharmaceutical for treating a disease or staging disease by administering a pharmaceutical to a sample containing markers for a disease, detecting the amount of at least one marker of the disease in the sample, and analyzing the amount of the marker in the sample, whereby the amount of marker correlates to pharmaceutical efficacy or disease stage. Markers for gynecological disease selected from the list in Table 8. An immuno-imaging agent comprising labeled antibodies, whereby the labeled antibodies are isolated and reactive to proteins overexpressed in vivo. Informatics software for analyzing the arrays of claim 1, the software including analyzing means for analyzing the arrays.