Patents Represented by Attorney Law Offices of Albert Wai-Kit Chan, LLC

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  • Genetically modified tumor-targeted bacteria with reduced virulence
    Patent number: 6863894
    Abstract: The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The invention is also directed to Salmonella sp. containing a genetically modified msbB gene as well as an genetic modification in a biosynthetic pathway gene such as the purI gene. The present invention further relates to the therapeutic use of the mutant Salmonella for growth inhibition and/or reduction in volume of solid tumors.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: March 8, 2005
    Assignees: Vion Pharmaceuticals, Inc., Yale University
    Inventors: David Bermudes, Kenneth Brooks Low