Patents Represented by Attorney Lawrence S. Pope
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Patent number: 5248479Abstract: A device for performing agglutination immunoassay reactions and the like is disclosed. The device includes a first hydrophilic layer, a second liquid-occlusive layer parallel to and overlying the first layer, and a third layer parallel to and overlying the second layer. The third layer has a transparent opening for observing particles. The second layer is interposed between and in adherent relationship to the first and third layers. The second layer has at least one slot defining a channel for directing liquid conducted by capillary action through the chamber defined in conjunction with the first and third layers. This chamber has a proximate zone and a distal zone. The geometry of the chamber is modified to provide preferably outwardly diverging walls and provide a flowpath having different rates of flow per unit area along the paths.Type: GrantFiled: December 22, 1992Date of Patent: September 28, 1993Assignee: Abbott LaboratoriesInventors: Robert G. Parsons, Bob O. Basore, Michael B. O'Connell, Kevin J. Forney, Paul J. Ropella, Andrew J. Muetterties
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Patent number: 5239086Abstract: Disclosed is a substantially optically pure hapten, useful in an immunoassay for dextropropoxyphene and/or nordextropropoxyphene. The hapten corresponds to a specified structural formula (IX).Also disclosed is an immunogen derived from the hapten as well as an antibody raised in response to an immunogen derived from the hapten.Also disclosed is a fluorescent tracer derived from a substantially optically pure compound corresponding to the hapten, the tracer being useful in an immunoassay for dextropropoxyphene and/or nordextropropoxyphene.Also disclosed is an improved immunoassay for determining dextropropoxyphene and/or nordextropropoxyphene in a biological sample involving a step of contacting the sample with antibodies raised in response to the immunogen.Type: GrantFiled: July 29, 1991Date of Patent: August 24, 1993Assignee: Abbott LaboratoriesInventors: Robert E. Dubler, Jonathan Grote, Donna R. Kuhn
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Patent number: 5239057Abstract: The present invention is directed to a fluorescence polarization immunoassay for cyclosporin A and metabolites thereof. The present invention also relates to novel cyclosporin A derivative compounds useful in fluorescence polarization techniques. Included among the novel compounds are cyclosporin A derivatives where the amino acid in the first position is altered. The cyclosporin A derivatives are useful in forming immunogens for raising antibodies specific to cyclosporin A and metabolites thereof.Type: GrantFiled: October 15, 1991Date of Patent: August 24, 1993Assignee: Abbott LaboratoriesInventors: Nai-Yi Wang, Philip P. Wang, Marjorie A. Morrison
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Patent number: 5229268Abstract: A method for performing a diagnostic immunoassay by a solid phase separation. To a reaction mixture of a test sample and labeled antibody, which forms a complex of any analyte present in the test sample, is added a solid phase material having a compound capable of binding any excess labeled antibody. The solid phase material is chosen to rapidly settle whereby a solid and liquid phase is formed. The liquid phase can then be extracted to measure the amount of analyte-labeled antibody present therein.Type: GrantFiled: November 24, 1987Date of Patent: July 20, 1993Assignee: Abbott LaboratoriesInventors: Terry A. Pry, Edward N. Granados, Philip M. Hill
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Patent number: 5227474Abstract: The present invention provides bifunctional chelating agents comprising a unique substrate reactive moiety incorporated into a carboxymethyl arm of a polyaminopolycarboxylate chelating framework capable of forming stable complexes with metal ions.Type: GrantFiled: May 28, 1991Date of Patent: July 13, 1993Assignee: Abbott LaboratoriesInventors: David K. Johnson, Steven J. Kline
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Patent number: 5217704Abstract: The present invention provides a metal ion scavenging procedure and antibody compositions for radioimmunoscintigraphy and cytotoxic radioimmunotherapy having chelator concentrations of greater than about 10.sup.-4 M which are optimized with respect to their metal binding capacity such that highly efficient labelling of the antibody is achieved in a simple one step procedure using readily available sources of radiometal ions.Type: GrantFiled: December 27, 1991Date of Patent: June 8, 1993Assignee: Abbott LaboratoriesInventors: David K. Johnson, Patrick E. Rogers
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Patent number: 5210040Abstract: The present invention provides for novel homogeneous immunoassay systems involving complement-mediated lysis of marker-encapsulating lipid vesicles (liposomes) for detection of analyte in a fluid sample. These systems do not require the separation of unbound antigens and/or antibody conjugates yet provide highly sensitive procedures for analyte detection. Liposomes containing a marker, are coupled to antibody fragments in a way which confers the liposomes with immunological specificity yet avoids sensitizing the liposomes to complement mediated lysis in the absence of analyte. Antibody sensitized liposomes (the first reagent) are sequentially incubated with an analyte-containing sample, and optionally "dummy" liposomes, which do not contain encapsulated marker, a second antibody (the second reagent), and finally with a complement source such as plasma. Complement is activated by the liposome-antibody-antigen-second antibody complex causing liposome lysis and a concomitant release of marker.Type: GrantFiled: February 22, 1990Date of Patent: May 11, 1993Assignee: Abbott LaboratoriesInventors: Yi-Her Jou, Roger C. Hu, Peter A. Lagocki
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Patent number: 5202270Abstract: The present invention is directed to a fluorescence polarization assay for benzoyl ecgonine and substituted benzoyl ecgonine compounds in biological fluids, and to a method of making reagents therefor. Specifically, tracers, immunogens and antibodies are disclosed. The tracers and the immunogens are made from substituted benzoyl ecgonine compounds. A fluorescein moiety is included in the tracer, while a poly(amino acid) forms a part of the immunogen. The assay is conducted by measuring the degree of polarization retention of plane polarized light that has been passed through a sample containing antiserum and tracer.Type: GrantFiled: August 30, 1990Date of Patent: April 13, 1993Assignee: Abbott LaboratoriesInventors: Frank S. Ungemach, Daniel S. Nam, Oliver H. Meek
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Patent number: 5191066Abstract: A process for producing a derivatized immunoglobulin and conjugates prepared therewith are provided. The derivatized immunoglobulin is produced by introducing sulfhydryl groups in the Fc region of an immunoglobulin wherein the Fab portion of the immunoglobulin is not altered. The derivatized immunoglobulin is used to prepare conjugates with various detectable moieties wherein a controlled distance exists between the Fc region of the immunoglobulin and the detectable moiety. The conjugates are particularly useful for performing immunoassays, and exhibit improved longevity, specificity and sensitivity.Type: GrantFiled: December 7, 1990Date of Patent: March 2, 1993Assignee: Abbott LaboratoriesInventors: Christopher Bieniarz, Mazhar Husain, Howard E. Bond
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Patent number: 5160701Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens, antibodies, or other ligands or DNA segments. The material and device comprises a reaction site having procedural controls and an analyte binding area capable of being simultaneously contacted by the sample and reagent used in the performance of the assay. The procedural controls and analyte binding areas operate to provide readable results as to the presence or absence of analyte and simultaneously verify the assay procedure and therefore the assay result.Type: GrantFiled: April 15, 1991Date of Patent: November 3, 1992Assignee: Abbott LaboratoriesInventors: William E. Brown, III, Sarah E. Safford, John M. Clemens
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Patent number: 5149622Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.Type: GrantFiled: May 21, 1990Date of Patent: September 22, 1992Assignee: Abbott LaboratoriesInventors: William E. Brown, John M. Clemens, Sharon M. Devereaux, John G. Hofler, Kevin M. Knigge, Sarah E. Safford
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Patent number: 5130118Abstract: The present invention provides a metal ion scavenging procedure and antibody compositions for radioimmunoscintigraphy and cytotoxic radioimmunotherapy having chelator concentrations of greater than about 10.sup.-4 M which are optimized with respect to their metal binding capacity such that highly efficient labelling of the antibody is achieved in a simple one step procedure using readily available sources of radiometal ions.Type: GrantFiled: November 6, 1987Date of Patent: July 14, 1992Assignee: Abbott LaboratoriesInventors: David K. Johnson, Patrick E. Rogers
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Patent number: 5008080Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens, antibodies, or other ligands or DNA segments. The material and device comprises a reaction site having procedural controls and an analyte binding area capable of being simultaneously contacted by the sample and reagent used in the performance of the assay. The procedural controls and analyte binding areas operate to provide readable results as to the presence or absence of analyte and simultaneously verify the assay procedure and therefore the assay result.Type: GrantFiled: February 6, 1990Date of Patent: April 16, 1991Assignee: Abbott LaboratoriesInventors: William E. Brown, III, Sarah E. Safford, John M. Clemens
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Patent number: 4698362Abstract: The present disclosure is concerned with a technique for producing storage stable, non-caking, low viscosity pesticidal concentrates and the compositions so obtained. The technique involves milling a solid biologically active compound in a low viscosity aliphatic petroleum fraction in which it is slightly soluble until it has an average particle size of less than about 10 microns at a temperature in excess of about 40.degree. C. in the presence of a high or ultra-high surface area silica and lecithin. The milling is conducted in such a manner as to avoid melting any significant portion of the biologically active compound undergoing milling. The concentrate so obtained, typically display room temperature viscosities between about 20 and 2,000 cps and contain between about 120 and 480 grams per liter of biologically active compound.Type: GrantFiled: March 14, 1985Date of Patent: October 6, 1987Assignee: Mobay CorporationInventor: Jimmie G. Shafer
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Patent number: 4690947Abstract: Arthropodicidal compositions in the form of synergistic combinations of (A) cyano-(4-fluoro-3-phenoxyphenyl)-methyl 3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropanecarboxylate plus (B) O-ethyl-O-[4-(methylthio)-phenyl]-S-propyl phosphorodithioate, (A) plus (C) N.sup.1 -(4-chloro-O-tolyl)-N,N-dimethylformamidine, (A) plus (B) plus (C), (A) plus (D) 1-(tricyclohexylstannyl)-1H-1,2,4-triazole, (A) plus (E) tricyclohexyl hydroxystannane, or (A) plus (F) hexakis-(2-methyl-2-phenylpropyl)-distannoxane, which are individually known compounds, which combinations possess synergistic arthropidicidal properties especially for the control of mites.Type: GrantFiled: November 25, 1985Date of Patent: September 1, 1987Assignee: Mobay CorporationInventors: Walter M. Zeck, Donald E. Simonet
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Patent number: 4676234Abstract: The invention relates to a self-hardening material for supporting bandages which is packaged with exclusion of moisture and consists of an air-permeable, flexible carrier material which is impregnated and/or coated with a compound possessing at least 2 NCO groups. The self-hardening material has a greatly improved shelf life by being stored substantially oxygen-free in an air-tight pack.Type: GrantFiled: February 18, 1986Date of Patent: June 30, 1987Assignee: Bayer AktiengesellschaftInventors: Christian Wegner, Gottfried Schneider, Hans-Uwe Lanzke, Wolfram Mayer, Kuno Wagner, Wulf von Bonin, Ulrich von Gizycki, Dietmar Schaepel
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Patent number: 4673410Abstract: The present disclosure is concerned with enhancing the solubility of dispersed anionic dyes upon the dilution of their dispersions with room temperature water. Concentrated dispersions of such dyes with acceptable stability and low shear viscosities are disclosed which are more readily diluted to dissolve the dispersed dyestuff because they contain certain chelating agents are described. These agents have at least one free or appropriately neutralized acid group, with carboxylic acid groups being preferred. The appropriae cations include ammonium or lithium ions. The free acid groups are subsequently neutralized with these appropriae cations so that the final dispersions are preferably about neutral, i.e have pH values about 7. A further improvement to the dilutability by the addition of a surfactant, preferably a non-ionic surfactant, is also discssed.Type: GrantFiled: November 19, 1985Date of Patent: June 16, 1987Assignee: Mobay CorporationInventors: Charles W. Sandefur, Thomas J. Thomas
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Patent number: 4661099Abstract: The present disclosure is concerned with self-adhesive sheet-like structures made by adhering an adhesive polyurethane gel material to a supporting substrate and the utilization of such structures in the medical field to adhere materials such as plasters, wound dressings and appliances to the human body, and in other fields to connect articles, such as the parts of a fractured or cracked object, to one another by means of an adhesive bond. The gel is formed by immobilizing a high molecular weight polymeric polyol in the matrix of a covalently crosslinked polyurethane which is prepared by reacting polyisocyanates having an isocyanate functionality of at least 2 with higher molecular weight polyhydroxyl compounds having a hydroxyl functionality of at least 3. These reactants are selected in accordance with the following formula which relates the isocyanate number, K, (isocyanate to hydroxyl equivalents ratio times 100) to the average functionalities of the polyisocyanates (F.sub.Type: GrantFiled: November 8, 1984Date of Patent: April 28, 1987Assignee: Bayer AktiengesellschaftInventors: Miklos von Bittera, Dietmar Schapel, Ulrich von Gizycki, Roland Rupp
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Patent number: 4621940Abstract: The present application is concerned with an elongated stiff but bendable plastic article which finds particular utility in highway delineators. The article has a central lens shape in the cross-section perpendicular to its longitudinal axis which is formed by joining two sheets along both of their longitudinal edges. The sheets both have parallel longitudinal edges and are configured in an arc in their shorter dimension. A reverse radius is provided in each longitudinal edge just before it joins the similar edge of the other sheet to allow the article to bent 90.degree. across its longitudinal axis in the plane of the sheets' juncture without significant plastic deformation. The article is constructed of a thermoplastic that can sustain substantial elastic deformation.Type: GrantFiled: September 20, 1984Date of Patent: November 11, 1986Assignee: Mobay Chemical CorporationInventor: Howard A. Anderson
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Patent number: 4581397Abstract: A molding composition comprising a polycarbonate resin and an impact modifier containing an acrylate or a methacrylate functionality is imparted improved processability and freedom from splay upon the admixing of a certain stabilizer therewith.Type: GrantFiled: September 29, 1983Date of Patent: April 8, 1986Assignee: Mobay CorporationInventor: Mark W. Witman