Abstract: The present invention relates to hydroxamic acid derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, to treat a glutamate abnormality and to treat a prostate disease in an animal.
Type:
Grant
Filed:
April 4, 1997
Date of Patent:
October 5, 1999
Assignee:
Guilford Pharmaceuticals Inc.
Inventors:
Paul F. Jackson, Kevin L. Tays, Keith M. Maclin, Barbara S. Slusher