Abstract: The invention relates to a novel labeling reactant, suitable for labeling of a biospecific binding reactant using solid-phase synthesis. The invention further concerns new labeling methods. The novel labeling reactant has the formula (I) ##STR1## wherein -A- is a bivalent aromatic structure capable of absorbing light or energy and transferring the excitation energy to a lanthanide ion after the product made by the said solid-phase synthesis has been released from the used solid support, deprotected and converted to a lanthanide chelate;-G- is a bridge replacing a hydrogen atom in A;R is a protected amino acid residue --CH(NHX)COOH, where X is a transient protecting group, or its active ester, where said ester is e.g. an N-hydroxysuccinimido, p-nitrophenol or pentafluorophenol ester; andR' is --COOR'" where R'" is an alkyl of 1 to 4 carbon atoms, phenyl or benzyl, which phenyl or benzyl can be substituted or unsubstituted.

Abstract: The invention relates to a siloxane-based elastomer intended for controlling the permeation of drugs, wherein the elastomer includes 3,3,3,-trifluoropropyl groups attached to the Si-atoms of the siloxane units.The invention relates also to a method for the preparation of a siloxane-based elastomer including 3,3,3,-trifluoropropyl substituents, where the elastomer is intended for controlling the permeation of drugs.In the method eitheri) a 3,3,3,-trifluoropropyl-substituted vinyl-functional polysiloxane component and a silicon hydride-functional crosslinking agent are crosslinked in the presence of a catalyst, orii) a 3,3,3,-trifluoropropyl-substituted polysiloxane component is crosslinked in the presence of a peroxide catalyst.

Abstract: A non-competitive method for the determination of analytes. Initially the analyte is bound to a specific binding partner, after which the unoccupied binding sites of the binding partner are inactivated. The bound analyte is then dissociated from the binding partner and replaced by a labeled marker, after which the bound labeled marker is determined. The signal from the bound labeled marker is directly proportional to the initial amount of analyte in the sample, which makes the present method more favorable than the competitive assays.

Abstract: An automatic safety protector relates to a safety protecting device for a traveling motor vehicle. It is installed with a set of automatic flameout, braking mechanisms in front of the head of a motor vehicle, and a shock absorbing device is mounted between a fender-guard and a frame side member. When motor vehicle is in collision, the former realize automatic flameout and braking, and the latter buffers the impact force on collision, thereby the loss due to a collision accident is minimized.

Abstract: Portable device for relief of pain and contractures and skin rejuvenation comprising a head (10) for applying electric current pulses to the skin of a user and a handle (16) held by the user's hand. The head has the shape of a cylinder portion of which the directrix has a convex shape, the head having at least one electrode (22, 24) situated on its external surface or at a constant distance from said external surface and of which at least one portion is situated on each generatrix of the cylinder part susceptible to be in contact with the user's skin. Thus, the head is always in contact with the user's skin by one of the generatrices lines of the cylinder portion comprising an electrode portion independently of the inclination of the head with respect to the user's skin.

Abstract: An automatically inflatable, deflatable and foldable solar-powered cooler mattress with a sunshade, including an auxiliary device for automatically inflating and deflating the mattress, which device includes an array of photovoltaic cells (1) for supplying the power needed to operate a motor (2) driving a turbine (4) which rotates to draw air in through a channel (9) in the mattress (5), said motor (2) also being operable to deflate the mattress (5) when the polarity of the motor power supply is reversed; a beverage cooler device comprising a water-soaked foam cylinder (17) so that when the turbine (4) is driven by the motor (2) to generate an air flow, said air flow causes evaporation of the water, thereby cooling the cylinder and an ultra-lightweight adjustable sunshade (10), one edge of the mattress being provided with a guide rail and a clamping system enabling the sunshade to be used in a variety of positions.

Abstract: Process of assessment of ocular dysfunctions, characterized in that the patient's eye (1) is placed to a previously defined distance from a lightening glare source (3), so that he can visualize a target (4) placed next to the lightening glare source (3), then the target (4) is approached from the source (3) so that the patient becomes unable to distinguish the target (4) from the source (3) and then, the target (4) is slowly taken away from the source (3), up to the exact moment when the patient distinguishes again the target (4), and at this time, the incident light angle o between the source (3) and the target (4) is measured.

Abstract: An extraction method is disclosed, where organic impurities are removed from a phase essentially containing sulfuric acid, by means of supercritical or liquid carbon dioxide. In particular, the spent sulfuric acid from a process for production of alkylate fuel may be regenerated for re-introduction into the process without incineration.

Abstract: A pharmaceutical composition containing a microemulsion made up of a hydrophilic component, a lipophilic component, a surfactant and a drug, where the hydrophilic component, the lipophilic component and the surfactant form, when examined on a macroscopic scale, a one-phase solution. The hydrophilic component is dispersed as colloidal droplets in the lipophilic component, or the lipophilic component is dispersed as colloidal droplets in the hydrophilic component. According to still another alternative, the hydrophilic and the lipophilic components form a microemulsion with bicontinuous structure where the components form elongated adjacent channels. The drug is dissolved in the dispersed component or, in the case of a microemulsion with bicontinuous structure, in the hydrophilic or the lipophilic component. The microemulsion is stabilized by means of the surfactant. It is characteristic that a gelatinizer and water are added to the microemulsion thereby bringing the microemulsion into a gel form.

Abstract: A method of treatment of osteo-articular disease which includes administering an effective amount of a pharmaceutical composition containing a compound of specified formula and an excipient to a patient in need of such treatment. The compounds of specified formula have a phosphonate group on one end and a silanol or silanol precursor on the opposite end, and can inhibit serine proteases.

Abstract: The invention is a luminescence energy transfer based bioaffinity assay comprising a first group labeled with an energy donating compound (donor) and a second group labeled with an energy accepting compound (acceptor), wherein the donor is a luminescent lanthanide chelate having a long excited state lifetime and the acceptor is either a luminescent compound having a short excited state lifetime or a nonluminescent compound. The increase or decrease, respectively, in the energy transfer from the donor to the acceptor resulting from shortening or lengthening, respectively, of the distance between the said groups, is measured. Characteristic for the invention is that the lanthanide energy emission and the acceptor energy absorption do not essentially or not at all overlap each other.

Abstract: A sleeve (10) for use as a mould for protecting, repairing or renovating a pipe (12) for carrying water, gas or other fluids. A liquid material such as polyurethane or epoxy resin is injected into the sleeve so that, as it polymerizes, it protects or seals the pipe section covered by the sleeve. The sleeve includes a plurality of identical modules (14, 16, 18, 20, 22) assembled to form the mould and each including a male portion and a female portion linked by an intermediate portion. The male portion of one module is designed to fit into the female portion of the adjacent module.

Abstract: A self-opening and self-closing device enabling entry into a controlled access area includes a gate with two laterally retractable panels that may be opened by inserting a ticket or access card into a control mechanism. Each of the panels is controlled by a respective motor operated by the control mechanism. Each panel is secured to at least two runner members that are each operated by a roller secured to a link arm. The link arms are rotationally interconnected and rotated by the respective motor. Simultaneous rotation of the arms in opposite directions moves the two panels together (or apart) and thus closes (or opens) the entry device by moving each panel into a position in which it is locked by the respective arm in the horizontal position.