Abstract: The present invention provides heat exchange devices for heating and/or cooling parts of the body for therapeutic treatment of injury. The heat exchange devices include a cooling module with a housing enclosing a cooling chamber. A thermoelectric Peltier unit has a cooled surface sealed against an opening in the housing and a pump is provided for pumping heat exchange fluid through the cooling chamber directly into contact with the cooled surface and through conduits to a patient blanket. A reservoir containing refrigerant is in flow communication with the chamber in the cooling module housing and refrigerant only flows into the housing when depleted from the recirculation flow path between the cooling module and the blanket. Another device uses a thermoelectric unit disposed between two water pumps each of which pumps water to different sections of a flexible water bag which is strapped to the affected area of the user.