Patents Represented by Attorney, Agent or Law Firm Mary McCarthy
  • NF-?B inhibitors
    Patent number: 7375131
    Abstract: The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-? phosphorylation of I?B. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-?B in which diseases excessive activation of NF-?B is implicated.
    Type: Grant
    Filed: May 29, 2003
    Date of Patent: May 20, 2008
    Assignee: SmithKlineBeecham Corp.
    Inventors: James F. Callahan, Yue Hu Li
  • Peptide deformylase inhibitors
    Patent number: 6806369
    Abstract: PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: November 5, 2002
    Date of Patent: October 19, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Kelly M. Aubart, Siegfried B. Christensen, IV, Jacques Briand, Maxwell David Cummings
  • Peptide deformylase inhibitors
    Patent number: 6797730
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: September 28, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Jia-Ning Xiang, Siegfried B. Christensen, IV, Jinhwa Lee
  • Use of glucose uptake enhancer for reducing post-ischemic injury of the heart
    Patent number: 6613785
    Abstract: A method for reducing post-ischaemic injury of the heart and/or improving the functional recovery of the heart following myocardial ischaemia which method comprises administration of an effective, non-toxic amount of a glucose uptake enhancer to a human or non-human mammal in need thereof.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: September 2, 2003
    Assignees: Smithkline Beecham plc, Glaxosmithkline Laboratoires Pharmaceutiques
    Inventors: Antoine Michel Alain Bril, Robin Edwin Buckingham, Nassirah Khandoudi
  • Phenyl urea and phenyl thiourea derivatives
    Patent number: 6596730
    Abstract: Compounds of formula (I): in which: one of X and Y is N and the other is CH; Z represents oxygen or sulfur; and R1 to R7 represent various substituent groups; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: July 22, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Steven Coulton, Amanda Johns, Roderick Alan Porter
  • Process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives
    Patent number: 6479659
    Abstract: Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentano[b]pyridine derivatives. The most preferred compounds prepared by this inventino are (+)(1S, 2R, 3S)-3-[2-(2-hydroxyeth-1-yloxy)-4-methoxyphenyl]-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof and (+)(1S, 2R, 3S)-3-[(2-carboxymethoxy-4-methoxyphenyl)-1- (3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof. Also invented are novel intermediates useful in preparing these compounds.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: November 12, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Yemane Woldeselassie Andemichael, Neil Howard Baine, William Morrow Clark, Conrad John Kowalski, Michael Anthony McGuire, Robert John Mills
  • Bicyclic fibrinogen antagonists
    Patent number: 5602145
    Abstract: This invention relates to compounds of the formula: ##STR1## which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: February 11, 1997
    Assignee: Smithkline Beecham Corporation
    Inventor: James Samanen