Abstract: A method for computer-generating interaction-specific knowledge base for rapidly improving or optimizing a performance of an object comprises performing, according to computer-designed test matrices, at least several automatic experimental cycles on selected control variables. In at least one of the automatic experimental cycles after the first the computer plans a new test matrix designed to minimize or remove at least one expected two-variable interaction from a main effect of a designated control variable. A machine operating according to the method is also available.