Abstract: Communication with a computer through a gameport is provided in a fashion which provides an increased information bandwidth, e.g. for coupling three or more joysticks or other peripheral devices and/or a total of five or more buttons. In one embodiment, information from joysticks or other peripheral devices is provided to the synchronous serial digitized form over the 4 button lines. X-A and Y-A lines of the gameport are used for providing, to the external devices, timing information from which load and clock signals are generated to control output of information from the peripheral devices to complete.

Abstract: The system includes multiple components that may be used individually, or in conjunction with other components of the system, including a copy holder, paper organizer and a monitor-mounted copy holder. The copy holder/stand accommodates a variety of paper sizes in either portrait or landscape orientation. The copy stand includes a base stand and a removable copy holder, thus allowing the copy holder to be used as a clip board. The copy holder is rotatable about the base stand, thus allowing variation of the relative angle between the user and the copy holder. The copy holder includes at least one clip, and preferably at least two different types of clips. The clips may hold papers and documents against the copy holder as well as provide a means of highlighting or marking regions of particular interest on a document page. The paper organizer may either stand-alone or be held within an opening in the base stand of the copy holder.

Abstract: Protocols and architecture for secure virtual private networks. Intraenterprise data communications are supported in a secure manner over the Internet or other public network space with the implementation of secure virtual private networks. Members of a virtual private network group exchange data that may be compressed, encrypted and authenticated, if the exchange is between members of the group.

Abstract: Methods are disclosed for adjusting corneal curvature to correct the refractive error of an eye. The method comprises a first corrective event in which the corneal curvature is adjusted to correct the eye to 20/20 vision or slightly over-correct the eye past 20/20 vision. After the first corrective event, a second corrective event adjusts the corneal curvature to 20/20 vision. The second corrective event causes significantly less trauma to the eye, and thus, compared to the first corrective event, the error from healing and other factors is greatly reduced in this second corrective event. Devices for implementing these methods are also disclosed.

Abstract: The invention pertains to a high resolution imaging microscope, and more specifically, to a digital imaging spectrophotometer (DIS) configured to enable the direct determination of the ground state absorption spectra of microscopic samples from violet to near infrared. The instrument is capable of simultaneously recording hundreds of spectra, and can, using image processing techniques identify features (such as a single microbial cell) on a microscope slide or thin section. The invention additionally relates to the use of such an instrument.

Abstract: A system is described for the treatment of aircraft toilet waste water to permit discharge of the treated water to the atmosphere during flight, utilizing the pressure differential that is created between the aircraft's cabin pressure and the external atmosphere. The system includes a filter to remove suspended solids and other contaminants from the waste water, and may also include means to purify the water to potable water standards and means to recirculate the treated water for reuse on the aircraft.

Abstract: A cursor positioning system for use with computer systems employing relative-pointing devices (e.g., trackballs or mice) for cursor positioning functions. The cursor positioning system employs a cursor driver, stored in a memory of the computer system and responsive to cursor positioning signals from the relative-pointing device, to enable fast and accurate cursor positioning to specific, predefined locations. The cursor driver responds to user-actuated signals, such as "clicks" or keystrokes to record cursor position objects at particular cursor locations. Thereafter, during cursor position selection mode, initiated by a keystroke or relative-pointing device signal, the cursor's position is moved from position object to position object. The preferred embodiment also provides for recording of bias objects, typically the same as the position objects, to attract the cursor's location towards them. This attraction reduces undershoot and overshoot of the cursor.

Abstract: The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human heregulin-.beta.1 having enhanced affinity for the ErbB-3 and ErbB-4 receptors. These variants include at least one amino acid substitution and can include further modifications. The invention also provides nucleic acid molecules encoding heregulin variants and related vectors, host cells, pharmaceutical compositions, and methods.

Abstract: The present invention relates to porous crosslinked polymeric microbeads having cavities joined by interconnecting pores wherein at least some of the cavities at the interior of each microbead communicate with the surface of the microbead. The present invention also relates to a process for producing a porous, crosslinked polymeric microbead as well as the product of this process. This process involves combining an oil phase with an aqueous discontinuous phase to form an emulsion, adding the emulsion to an aqueous suspension medium to form an oil-in-water suspension of dispersed emulsion droplets, and polymerizing the emulsion droplets to form microbeads. At least 10% of the microbeads produced in accordance with the present invention are substantially spherical or substantially ellipsoidal or a combination of the two.

Abstract: Oligonucleotide sequences encoding gp120 polypeptides from breakthrough isolates of vaccine trials using MN-rgp120 and the encoded gp120 polypeptides are provided. Use of the gp120 polypeptides from one or more of the isolates in a subunit vaccine, usually together with MN-rgp120, can provide protection against HIV strains that are sufficiently different from the vaccine strain (e.g.; MN-rgp120) that the vaccine does not confer protection against those strains. Antibodies induced by the polypeptides are also provided.

Abstract: Methods for preparing homogeneous magnetic fluid compositions capable of forming ordered one dimensional structures or two dimensional lattices in response to externally applied magnetic fields are disclosed. The compositions are prepared using improved co-precipitation methods in which the steps of the procedure have been tuned to reduce sample heterogeneity. Fe.sub.3 O.sub.4 or MnFe.sub.2 O.sub.4 particles are coated with a surfactant and dispersed in a continuous carrier phase to form these homogeneous magnetic fluid compositions. The ability of these compositions to generate ordered structures can be tested by holding a magnet near a thin film of the compositions and observing the formation of colors in the region near the magnet. Methods for controlling the characteristic spacing of the ordered structures formed by the composition also are disclosed.

Abstract: A multi-purpose scanner that can be integrated into a computer. In one embodiment, the multi-purpose scanner functions as a desktop scanner. It includes a scanning engine and an external housing. The external housing substantially encapsulates the scanning engine to reduce electromagnetic interference to the scanning engine. In another embodiment, the multi-purpose scanner scans with scanning engine mechanically attached to the computer. The scanning engine includes an internal body, a chassis and a positioning assembly. The chassis holds the internal body, and the assembly moves the internal body relative to the chassis. In this embodiment, the scanner extends a part of the internal body out of the chassis in order to scan a medium. In a third embodiment, the multi-purpose scanner functions as a handheld scanner. The scanning engine includes a front-panel unit that is releasably attached to an engine unit.

Abstract: A method for drying microspheres in a fluidized bed is provided, along with a composition comprising microspheres dried by that method.

Abstract: A method and apparatus for adjusting corneal curvature of the eye comprising an adjustable split ring formed of an elastic hollow shell which is implantable into the cornea in encircling relation to the central optic zone of the cornea. The ring is filled by a predetermined amount with a select quantity of biocompatible material, either a fluid or strands of biocompatible suture material or polymethylmathacrylate, of predetermined size and length.The biocompatible filler material is strategically located within the elastic shell to alter its dimensions in thickness or diameter and thereby adjust the corneal curvature to correct for refractive error. Further adjustment of the ring may be made post-operatively after implantation by select removal of the biocompatible filler material.

Abstract: The invention relates to a process for rearing bumblebee queens (genus Bombus) by generating a colony with workers in the presence of fertilized eggs and/or larvae, in a room with a controlled climate provided with food, and allowing the colony to grow until bumblebee queens are produced. The process constitutes a significant improvement in the rearing of bumblebee queens. The invention also relates to a process for rearing bumblebees (genus Bombus).

Abstract: A combined toothbrush and toothpaste dispenser is described which is adapted to store toothpaste in a reservoir in the casing of the brush and to deposit a controlled quantity of the stored toothpaste directly onto the brush surface. The toothbrush comprises: (1) a brush 1 having bristles 8 which are attached to and supported by a brush head portion 5 and a handle 2, and (2) a casing 11 made of flexible material containing a reservoir 7 within the casing. The toothbrush is operated by squeezing the casing which causes toothpaste to be deposited from the reservoir onto the bristles. The upper surface of the bristles may have cavities 12 to receive and contain the toothpaste.

Abstract: The present invention relates to a porous crosslinked hydrophilic polymeric material having cavities joined by interconnecting pores wherein at least some of the cavities at the interior of the material communicate with the surface of the material. The present invention also relates to a process for producing the polymeric material. This process involves combining a hydrophilic monomer phase with an oil discontinuous phase to form an emulsion, and polymerizing the emulsion. The emulsion can be a high internal phase emulsion (i.e., a "HIPE"). The polymeric material can be produced in a variety of forms. In one embodiment the emulsion is suspended in an oil suspension medium, and emulsion droplets are polymerized to produce polymeric microbeads.

Abstract: A method for the rational design and preparation of vaccines based on HIV envelope polypeptides is described. In one embodiment, the method for making an HIV gp120 subunit vaccine for a geographic region comprises determining neutralizing epitopes in the V2 and/or C4 domains of gp120 of HIV isolates from the geographic region and selecting an HIV strain having gp120 a neutralizing epitope in the V2 or C4 domain which is common among isolates in the geographic region. In a preferred embodiment of the method, neutralizing epitopes for the V2, V3, and C4 domains of gp120 are determined. At least two HIV isolates having different neutralizing epitopes in the V2, V3, or C4 domain are selected and used to make the vaccine. The invention also provides a multivalent HIV gp120 subunit vaccine.