Abstract: The invention relates to methods and compositions for modulating ubiquitin dependent proteolysis.

Abstract: There is disclosed a method of mounting a wheel hub bearing assembly to the knuckle (10) of a vehicle suspension standard by forcefully inserting the outer race (20) of the bearing in a bore (11) in the knuckle (10). The bore has a groove (15) near its axially outer side to accommodate a snap ring (14) for axially securing the bearing's outer race (20) within the bore (11). Angularly spaced radial slots (24) are provided in the axially outer rim of the knuckle (10); a hub bearing unit is assembled separately. The snap ring (14, 14') is fitted over the hub at an axial location between the axially outer end portion (23) of the bearing outer race (20) and a portion (34) of the hub (16) facing said end portion (23); at least one axially tapered sliding surface (33, 34, 23) is provided between said facing portions (23, 34).